| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin (hemihydrate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.245727 |
| TXNRD1 | thioredoxin reductase 1 | 0.175516 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.116588 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.111801 |
| VIM | vimentin | 0.0964926 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0918523 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0894219 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0837009 |
| RAI1 | retinoic acid induced 1 | 0.0712322 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.064527 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0641424 |
| RTN4 | reticulon 4 | 0.0612252 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0548291 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0526202 |
| POTEF | POTE ankyrin domain family, member F | 0.0520795 |
| EZR | ezrin | 0.0485834 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0481684 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0477452 |
| TMEM41B | transmembrane protein 41B | 0.0470927 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.046976 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.04694 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.046752 |
| EREG | epiregulin | 0.046689 |
| ANGPTL4 | angiopoietin-like 4 | 0.0459706 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0456485 |
| LDHA | lactate dehydrogenase A | 0.044361 |
| CENPF | centromere protein F, 350/400kDa | 0.0439589 |
| MKI67 | marker of proliferation Ki-67 | 0.0418758 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0413934 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.040573 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0395163 |
| SPAG9 | sperm associated antigen 9 | 0.0385548 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0370841 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0360127 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0357708 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0340915 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0339746 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0336835 |
| ARRDC3 | arrestin domain containing 3 | 0.0335842 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0330975 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0325685 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0325674 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0323641 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0317631 |
| JMJD1C | jumonji domain containing 1C | 0.0312741 |
| SET | SET nuclear proto-oncogene | 0.0312682 |
| EGR1 | early growth response 1 | 0.0310469 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0308363 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.030651 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0304001 |
| UPP1 | uridine phosphorylase 1 | 0.0303085 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0292154 |
| MATR3 | matrin 3 | 0.0291852 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0288883 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0287807 |
| PLK2 | polo-like kinase 2 | 0.0279149 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0276927 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0274516 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0273872 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0267959 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0267789 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0266023 |
| WDR26 | WD repeat domain 26 | 0.0262 |
| SQSTM1 | sequestosome 1 | 0.0260955 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0259789 |
| JUN | jun proto-oncogene | 0.0258061 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0254821 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0253583 |
| DIAPH3 | diaphanous-related formin 3 | 0.0253514 |
| ERBIN | erbb2 interacting protein | 0.0253115 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0251378 |
| PCBP2 | poly(rC) binding protein 2 | 0.0249364 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0247335 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0246955 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.024652 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0245813 |
| SEC24A | SEC24 family member A | 0.0245805 |
| SEPTIN7 | septin 7 | 0.0245719 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0243657 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0242597 |
| UBC | ubiquitin C | 0.0240683 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0239707 |
| CEP170 | centrosomal protein 170kDa | 0.0237566 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0236846 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0233418 |
| KLF6 | Kruppel-like factor 6 | 0.0232167 |
| TPX2 | TPX2, microtubule-associated | 0.0230798 |
| RLF | rearranged L-myc fusion | 0.0230585 |
| KIF5B | kinesin family member 5B | 0.0229679 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0228108 |
| ACTG1 | actin gamma 1 | 0.0227468 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0226813 |
| XPO1 | exportin 1 | 0.0226737 |
| FOSL1 | FOS-like antigen 1 | 0.0225732 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0225328 |
| VMP1 | vacuole membrane protein 1 | 0.0225284 |
| SNX9 | sorting nexin 9 | 0.0224236 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | 0.0224164 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0223904 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0223704 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TP63 | tumor protein p63 | -0.14169 |
| TMSB10 | thymosin beta 10 | -0.131235 |
| PTMA | prothymosin, alpha | -0.124739 |
| CADM2 | cell adhesion molecule 2 | -0.123574 |
| DST | dystonin | -0.122768 |
| MT2A | metallothionein 2A | -0.089749 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0830381 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0743505 |
| TNS3 | tensin 3 | -0.0723606 |
| CD44 | CD44 molecule (Indian blood group) | -0.0686783 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0637362 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0629967 |
| EFNA5 | ephrin-A5 | -0.0612987 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0603523 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0579122 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0572092 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0551878 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0528011 |
| RPL36 | ribosomal protein L36 | -0.0526393 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0526222 |
| PRELID2 | PRELI domain containing 2 | -0.0523696 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0510318 |
| EPHA4 | EPH receptor A4 | -0.0509381 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0505858 |
| HLA-B | major histocompatibility complex, class I, B | -0.0494149 |
| RNF213 | ring finger protein 213 | -0.0489629 |
| SP100 | SP100 nuclear antigen | -0.0486417 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0477188 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0471848 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0468911 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0463448 |
| EXOC4 | exocyst complex component 4 | -0.0460595 |
| RPS8 | ribosomal protein S8 | -0.0432605 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0432221 |
| RPL37A | ribosomal protein L37a | -0.042759 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0426592 |
| RPS3 | ribosomal protein S3 | -0.042627 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0425387 |
| EHBP1 | EH domain binding protein 1 | -0.0407393 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0405094 |
| FTL | ferritin, light polypeptide | -0.0398698 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0398692 |
| RPL31 | ribosomal protein L31 | -0.0385055 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0384206 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.038405 |
| CAPRIN2 | caprin family member 2 | -0.0371226 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0359776 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0355003 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0348739 |
| INTS6 | integrator complex subunit 6 | -0.0346837 |
| RPL19 | ribosomal protein L19 | -0.0340176 |
| DENND1A | DENN/MADD domain containing 1A | -0.033953 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0338091 |
| RPLP2 | ribosomal protein, large, P2 | -0.0337835 |
| PDE10A | phosphodiesterase 10A | -0.032207 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0313853 |
| RAD51B | RAD51 paralog B | -0.0312607 |
| RPL26 | ribosomal protein L26 | -0.0306198 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0300946 |
| RPS29 | ribosomal protein S29 | -0.0300249 |
| AEBP2 | AE binding protein 2 | -0.0299647 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0296077 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0289578 |
| RPS19 | ribosomal protein S19 | -0.028575 |
| RIGI | RNA sensor RIG-I | -0.0284708 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0280527 |
| PLSCR1 | phospholipid scramblase 1 | -0.0278208 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0273871 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0268884 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | -0.0265346 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | -0.0262589 |
| SMYD3 | SET and MYND domain containing 3 | -0.0259391 |
| EGFR | epidermal growth factor receptor | -0.0258637 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.025793 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0250137 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0249542 |
| VCL | vinculin | -0.0248662 |
| RPL35A | ribosomal protein L35a | -0.0243375 |
| RPL18 | ribosomal protein L18 | -0.024006 |
| DPH6 | diphthamine biosynthesis 6 | -0.0238854 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.023826 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0236137 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0235848 |
| CUX1 | cut-like homeobox 1 | -0.0233783 |
| TGM2 | transglutaminase 2 | -0.0233164 |
| PTK2 | protein tyrosine kinase 2 | -0.0231199 |
| WDR27 | WD repeat domain 27 | -0.0228026 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0226527 |
| FNIP1 | folliculin interacting protein 1 | -0.0225419 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0224054 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0221895 |
| NEK10 | NIMA-related kinase 10 | -0.022162 |
| NPAS2 | neuronal PAS domain protein 2 | -0.022125 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.021913 |
| PRKCE | protein kinase C, epsilon | -0.0218425 |
| HDAC9 | histone deacetylase 9 | -0.0216844 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0216835 |
| HM13 | histocompatibility (minor) 13 | -0.0214304 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0213573 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0209903 |
