| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.160905 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.111634 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.104307 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0785504 |
| SLTM | SAFB-like, transcription modulator | 0.0684091 |
| SPAG9 | sperm associated antigen 9 | 0.0657395 |
| MCL1 | myeloid cell leukemia 1 | 0.0651381 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0608756 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0583393 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0562742 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.053386 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0529305 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0516173 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0489673 |
| CES1 | carboxylesterase 1 | 0.0478387 |
| RUNX1 | runt-related transcription factor 1 | 0.0463251 |
| CCNL1 | cyclin L1 | 0.0458168 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0451864 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0445008 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0415393 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0409992 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0405293 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0397323 |
| VMP1 | vacuole membrane protein 1 | 0.0396061 |
| NPC1 | Niemann-Pick disease, type C1 | 0.039344 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0383419 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.038144 |
| CPE | carboxypeptidase E | 0.0380009 |
| EGR1 | early growth response 1 | 0.0373287 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0370343 |
| ZNF292 | zinc finger protein 292 | 0.0360839 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0353266 |
| FAM13A | family with sequence similarity 13, member A | 0.0350854 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0337698 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.033369 |
| JMJD1C | jumonji domain containing 1C | 0.0332719 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0331288 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0329596 |
| DENND4A | DENN/MADD domain containing 4A | 0.0328261 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0326105 |
| SMAD3 | SMAD family member 3 | 0.0321885 |
| ARRDC3 | arrestin domain containing 3 | 0.031663 |
| B2M | beta-2-microglobulin | 0.0310157 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0306423 |
| MYO1B | myosin IB | 0.0296354 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0295024 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0292946 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0291786 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.028509 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0283502 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0280588 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0273236 |
| KIAA1217 | KIAA1217 | 0.0270756 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0263043 |
| CSNK1E | casein kinase 1, epsilon | 0.026226 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0261313 |
| FRY | furry homolog (Drosophila) | 0.0259211 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0258802 |
| TMEM87A | transmembrane protein 87A | 0.02584 |
| ANKRD12 | ankyrin repeat domain 12 | 0.025772 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0257652 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0250871 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0244386 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0242865 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0242511 |
| TMEM165 | transmembrane protein 165 | 0.0241944 |
| YEATS2 | YEATS domain containing 2 | 0.0241904 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0239043 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0238074 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0236603 |
| MSN | moesin | 0.0235258 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0229903 |
| SYAP1 | synapse associated protein 1 | 0.0228912 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0225212 |
| GPHN | gephyrin | 0.0224389 |
| RTN4 | reticulon 4 | 0.0223774 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0222431 |
| TXNRD1 | thioredoxin reductase 1 | 0.0219696 |
| RNF145 | ring finger protein 145 | 0.0219522 |
| NFKB2 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 0.0216174 |
| GPATCH2L | G patch domain containing 2-like | 0.0215333 |
| ATP13A3 | ATPase type 13A3 | 0.0214321 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0213307 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.0212938 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.021245 |
| TSC22D2 | TSC22 domain family, member 2 | 0.021154 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0209708 |
| FOSL1 | FOS-like antigen 1 | 0.0209334 |
| KMT5B | lysine methyltransferase 5B | 0.0207483 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0207032 |
| PTEN | phosphatase and tensin homolog | 0.0205431 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0202882 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0201973 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0201228 |
| TBK1 | TANK-binding kinase 1 | 0.020116 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0198848 |
| PCBP2 | poly(rC) binding protein 2 | 0.0197186 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0196665 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0196481 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.019572 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.352209 |
| ASPH | aspartate beta-hydroxylase | -0.17921 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.174194 |
| LMO7 | LIM domain 7 | -0.137685 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.119798 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0982032 |
| ACTG1 | actin gamma 1 | -0.0978248 |
| AHNAK | AHNAK nucleoprotein | -0.093286 |
| TMSB10 | thymosin beta 10 | -0.0923178 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.087211 |
| SCEL | sciellin | -0.0817607 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0793811 |
| PTMA | prothymosin, alpha | -0.0783024 |
| HDLBP | high density lipoprotein binding protein | -0.0764091 |
| H1-0 | H1.0 linker histone | -0.0662934 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0661012 |
| CANX | calnexin | -0.0518647 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.04894 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0488797 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0482229 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0481487 |
| LDHA | lactate dehydrogenase A | -0.0474484 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.047126 |
| INTS6 | integrator complex subunit 6 | -0.0464461 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0457811 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0455533 |
| GM2A | GM2 ganglioside activator | -0.044365 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0423346 |
| KRT18 | keratin 18, type I | -0.0397219 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0393452 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0381343 |
| AGR2 | anterior gradient 2 | -0.0379119 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0371985 |
| MYOF | myoferlin | -0.0370042 |
| FLNB | filamin B, beta | -0.0363003 |
| KRT7 | keratin 7, type II | -0.0355756 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0354431 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0352257 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0349914 |
| S100A10 | S100 calcium binding protein A10 | -0.03426 |
| GOLGB1 | golgin B1 | -0.0334911 |
| ARCN1 | archain 1 | -0.0327023 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0326578 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0322835 |
| PTK2 | protein tyrosine kinase 2 | -0.0317639 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0314392 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0311965 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0311513 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0308279 |
| DSPP | dentin sialophosphoprotein | -0.0307912 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0307889 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0306652 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0301838 |
| DSG2 | desmoglein 2 | -0.0298678 |
| EHBP1 | EH domain binding protein 1 | -0.0289566 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0284997 |
| RPS24 | ribosomal protein S24 | -0.0280587 |
| CUX1 | cut-like homeobox 1 | -0.0279162 |
| GOLGA3 | golgin A3 | -0.0277754 |
| LRP12 | low density lipoprotein receptor-related protein 12 | -0.0274808 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0272533 |
| IER3 | immediate early response 3 | -0.0272525 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0270179 |
| CTBP2 | C-terminal binding protein 2 | -0.0268468 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0262259 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0259448 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.025645 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0256075 |
| RPL35A | ribosomal protein L35a | -0.0254723 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0252841 |
| HM13 | histocompatibility (minor) 13 | -0.0252304 |
| SEPTIN2 | septin 2 | -0.0251212 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.024951 |
| SEC24D | SEC24 family member D | -0.0248867 |
| NDRG1 | N-myc downstream regulated 1 | -0.0247371 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0247366 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.024638 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0245483 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0245129 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0243967 |
| RPS27A | ribosomal protein S27a | -0.0242835 |
| MCU | mitochondrial calcium uniporter | -0.0242557 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0241641 |
| FTL | ferritin, light polypeptide | -0.0241005 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0240793 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0240213 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.023933 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0234885 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0234244 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0230136 |
| RPS3 | ribosomal protein S3 | -0.0229399 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0229125 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0224093 |
| GRAMD1B | GRAM domain containing 1B | -0.0223793 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0223036 |
| CCND1 | cyclin D1 | -0.0220711 |
| N4BP2 | NEDD4 binding protein 2 | -0.0218616 |
| S100P | S100 calcium binding protein P | -0.0218284 |
| RPL37A | ribosomal protein L37a | -0.0218136 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0217816 |
