Canagliflozin (hemihydrate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin (hemihydrate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0777314
FTH1 ferritin, heavy polypeptide 1 0.0679021
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0622178
FAM13A family with sequence similarity 13, member A 0.0610235
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0540733
PDIA3 protein disulfide isomerase family A, member 3 0.0530545
NPC1 Niemann-Pick disease, type C1 0.0527971
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0519792
PCBP2 poly(rC) binding protein 2 0.0516685
ANGPTL4 angiopoietin-like 4 0.0433097
ATP13A3 ATPase type 13A3 0.0415184
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0409965
ESYT2 extended synaptotagmin-like protein 2 0.0407791
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0401254
UBA6 ubiquitin-like modifier activating enzyme 6 0.0399912
KMT2C lysine (K)-specific methyltransferase 2C 0.0397037
USP34 ubiquitin specific peptidase 34 0.0383879
NAMPT nicotinamide phosphoribosyltransferase 0.0376028
VEGFA vascular endothelial growth factor A 0.0373274
ZFP36L1 ZFP36 ring finger protein-like 1 0.0362272
SETD5 SET domain containing 5 0.0341793
RAI1 retinoic acid induced 1 0.0339463
DDIT4 DNA-damage-inducible transcript 4 0.0339038
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0328706
PRRC2C proline-rich coiled-coil 2C 0.0324147
HILPDA hypoxia inducible lipid droplet-associated 0.0323479
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0320383
ELL2 elongation factor, RNA polymerase II, 2 0.0319824
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0318125
GOLGA4 golgin A4 0.0309908
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0309744
CSDE1 cold shock domain containing E1, RNA-binding 0.0300237
MEF2A myocyte enhancer factor 2A 0.0296065
TBC1D15 TBC1 domain family, member 15 0.0295152
HYOU1 hypoxia up-regulated 1 0.02947
AKAP9 A kinase (PRKA) anchor protein 9 0.0293868
SLTM SAFB-like, transcription modulator 0.0291299
KTN1 kinectin 1 (kinesin receptor) 0.0290825
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0289666
RPS12 ribosomal protein S12 0.0287524
CA12 carbonic anhydrase XII 0.0281094
RNF24 ring finger protein 24 0.0276427
SRP54 signal recognition particle 54kDa 0.0273217
SRRM2 serine/arginine repetitive matrix 2 0.027286
MYO1B myosin IB 0.0270803
ZNF292 zinc finger protein 292 0.0263011
DSE dermatan sulfate epimerase 0.0262095
RPS3 ribosomal protein S3 0.0261691
DOCK5 dedicator of cytokinesis 5 0.0260487
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0259256
SEC23A Sec23 homolog A (S. cerevisiae) 0.0256034
ENO1 enolase 1, (alpha) 0.0254706
SRSF11 serine/arginine-rich splicing factor 11 0.0254497
EGFR epidermal growth factor receptor 0.0251363
KMT2E lysine (K)-specific methyltransferase 2E 0.0245917
KLF6 Kruppel-like factor 6 0.02456
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0243018
PELI1 pellino E3 ubiquitin protein ligase 1 0.0242624
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0241703
MAP2K1 mitogen-activated protein kinase kinase 1 0.0236073
MXI1 MAX interactor 1, dimerization protein 0.0235932
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0234672
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0233539
STC1 stanniocalcin 1 0.0230568
YEATS2 YEATS domain containing 2 0.022968
DGKD diacylglycerol kinase, delta 130kDa 0.0229173
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0228686
ITGAV integrin, alpha V 0.0228281
ZEB2 zinc finger E-box binding homeobox 2 0.0227992
SECISBP2L SECIS binding protein 2-like 0.0227757
RAB8B RAB8B, member RAS oncogene family 0.0227145
ARHGAP5 Rho GTPase activating protein 5 0.0226655
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0226562
CHD1 chromodomain helicase DNA binding protein 1 0.0223587
KDM2A lysine (K)-specific demethylase 2A 0.021893
FLNB filamin B, beta 0.0218546
TMEM165 transmembrane protein 165 0.0214765
RIPK2 receptor-interacting serine-threonine kinase 2 0.0212673
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0212162
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0212015
NFE2L1 nuclear factor, erythroid 2-like 1 0.021125
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0210231
TPR translocated promoter region, nuclear basket protein 0.0209141
XPO1 exportin 1 0.0208774
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0206885
TPM3 tropomyosin 3 0.0206647
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0206114
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.020601
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0204314
PGM3 phosphoglucomutase 3 0.0204103
SOS2 son of sevenless homolog 2 (Drosophila) 0.0201224
CABIN1 calcineurin binding protein 1 0.0200069
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.019975
TNPO3 transportin 3 0.0199068
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0198123
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0197803
YTHDC1 YTH domain containing 1 0.0197526
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0197448
VMP1 vacuole membrane protein 1 0.0196518
RPS7 ribosomal protein S7 0.0195437

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.434301
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.182495
RPL35A ribosomal protein L35a -0.092578
CD44 CD44 molecule (Indian blood group) -0.0922532
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0704957
CDH13 cadherin 13 -0.0668766
ANKRD28 ankyrin repeat domain 28 -0.0655623
FN1 fibronectin 1 -0.065518
KDM3A lysine (K)-specific demethylase 3A -0.0605065
UBC ubiquitin C -0.0596941
RPL34 ribosomal protein L34 -0.055718
EIF1 eukaryotic translation initiation factor 1 -0.0555736
AHNAK AHNAK nucleoprotein -0.0555064
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0547232
S100A10 S100 calcium binding protein A10 -0.053091
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0498149
NRG1 neuregulin 1 -0.0496641
RBM39 RNA binding motif protein 39 -0.0492342
ACTG1 actin gamma 1 -0.0469577
IGFBP3 insulin-like growth factor binding protein 3 -0.0459466
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0437196
LOC112694756 uncharaterized LOC112694756 -0.0432124
GLCCI1 glucocorticoid induced 1 -0.0427133
RPLP1 ribosomal protein, large, P1 -0.0419437
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0410806
TMSB10 thymosin beta 10 -0.0409064
TMSB4X thymosin beta 4, X-linked -0.0406054
RPS19 ribosomal protein S19 -0.0391952
LMAN1 lectin, mannose-binding, 1 -0.0391394
RPS24 ribosomal protein S24 -0.0391336
RAB1A RAB1A, member RAS oncogene family -0.0390837
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0389577
PARD3 par-3 family cell polarity regulator -0.0388283
EXT1 exostosin glycosyltransferase 1 -0.0378087
RPS21 ribosomal protein S21 -0.0372271
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0372205
TPT1 tumor protein, translationally-controlled 1 -0.0369412
GPC6 glypican 6 -0.0353358
RPS29 ribosomal protein S29 -0.0352335
AADAC arylacetamide deacetylase -0.035062
GLIS3 GLIS family zinc finger 3 -0.0346691
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0343518
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0340052
DPYD dihydropyrimidine dehydrogenase -0.0336697
EMP1 epithelial membrane protein 1 -0.033027
TMEM263 transmembrane protein 263 -0.0323746
NTN4 netrin 4 -0.0323706
RPL32 ribosomal protein L32 -0.0318574
GNAS GNAS complex locus -0.0317053
RPS6 ribosomal protein S6 -0.0316323
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0316226
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0315237
TM4SF1 transmembrane 4 L six family member 1 -0.0313585
IER3 immediate early response 3 -0.0313582
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0312579
ATG7 autophagy related 7 -0.0304651
RPL11 ribosomal protein L11 -0.0304506
H1-0 H1.0 linker histone -0.0299428
C15ORF48 chromosome 15 open reading frame 48 -0.0299367
SYT1 synaptotagmin I -0.0298896
HLA-B major histocompatibility complex, class I, B -0.029862
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0293611
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0292516
RPS11 ribosomal protein S11 -0.028763
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0282868
ANKRD11 ankyrin repeat domain 11 -0.0282456
SOD2 superoxide dismutase 2, mitochondrial -0.0280215
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0278682
CDK14 cyclin-dependent kinase 14 -0.0276065
INTS6 integrator complex subunit 6 -0.0275406
RPS23 ribosomal protein S23 -0.0272661
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0270605
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0266547
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0266407
RPL23 ribosomal protein L23 -0.0265715
TFPI2 tissue factor pathway inhibitor 2 -0.0265568
TBL1X transducin (beta)-like 1X-linked -0.0264348
RPL28 ribosomal protein L28 -0.0259298
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.025926
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0258109
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0257472
NDRG1 N-myc downstream regulated 1 -0.025714
COL12A1 collagen, type XII, alpha 1 -0.025513
ARF1 ADP-ribosylation factor 1 -0.0254853
VDAC1 voltage-dependent anion channel 1 -0.0253803
SP100 SP100 nuclear antigen -0.0249396
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.024756
CUX1 cut-like homeobox 1 -0.024422
RPL4 ribosomal protein L4 -0.0242817
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0240766
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0238064
RPLP0 ribosomal protein, large, P0 -0.0237426
USP3 ubiquitin specific peptidase 3 -0.0236468
RPL38 ribosomal protein L38 -0.0235808
PKM pyruvate kinase, muscle -0.0232165
SDC4 syndecan 4 -0.0229887
RPS15 ribosomal protein S15 -0.0229286
ATXN1 ataxin 1 -0.0227638
KIAA1217 KIAA1217 -0.0227567
FUS FUS RNA binding protein -0.0227463