| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin (hemihydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0859962 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0854572 |
| MCL1 | myeloid cell leukemia 1 | 0.0651061 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.046538 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0385357 |
| PYGL | phosphorylase, glycogen, liver | 0.0346971 |
| IGF2 | insulin-like growth factor 2 | 0.0346848 |
| EGR1 | early growth response 1 | 0.0336882 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0336482 |
| VMP1 | vacuole membrane protein 1 | 0.0331162 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0330407 |
| DENND4A | DENN/MADD domain containing 4A | 0.0324339 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0318677 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0310163 |
| VIM | vimentin | 0.0308837 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0274522 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0247063 |
| HYOU1 | hypoxia up-regulated 1 | 0.0241771 |
| STC1 | stanniocalcin 1 | 0.0238023 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0225046 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0222172 |
| ANGPTL4 | angiopoietin-like 4 | 0.0221777 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0217043 |
| MYO1E | myosin IE | 0.0207101 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.0202227 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.01985 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0195243 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0191914 |
| FLNA | filamin A, alpha | 0.0191813 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.019171 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0190996 |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.0189095 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0186384 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0185859 |
| AREG | amphiregulin | 0.0183687 |
| CENPF | centromere protein F, 350/400kDa | 0.0176689 |
| TPM3 | tropomyosin 3 | 0.0173108 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0172867 |
| AXL | AXL receptor tyrosine kinase | 0.0170577 |
| KLF6 | Kruppel-like factor 6 | 0.0169312 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0166321 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0166176 |
| LAMC2 | laminin, gamma 2 | 0.0164463 |
| TPM4 | tropomyosin 4 | 0.0164105 |
| UPP1 | uridine phosphorylase 1 | 0.016357 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0160892 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0160833 |
| NNMT | nicotinamide N-methyltransferase | 0.0158142 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0156212 |
| MSN | moesin | 0.0154589 |
| KIAA0319 | KIAA0319 | 0.0150762 |
| RPS12 | ribosomal protein S12 | 0.014709 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0145806 |
| EHD4 | EH-domain containing 4 | 0.0144525 |
| PFKP | phosphofructokinase, platelet | 0.0144187 |
| BRD2 | bromodomain containing 2 | 0.0144166 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0142601 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0142433 |
| NUP58 | nucleoporin 58 | 0.0138333 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0138271 |
| CBX3 | chromobox homolog 3 | 0.0137516 |
| ATXN1 | ataxin 1 | 0.0137385 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.013606 |
| ITGAV | integrin, alpha V | 0.0135193 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0134582 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.013419 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.013415 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0132946 |
| ARHGDIA | Rho GDP dissociation inhibitor (GDI) alpha | 0.0132433 |
| MKI67 | marker of proliferation Ki-67 | 0.0132302 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0132125 |
| NUMB | numb homolog (Drosophila) | 0.0130713 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0130415 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0129419 |
| PRRC2A | proline-rich coiled-coil 2A | 0.012758 |
| IL6 | interleukin 6 | 0.0124773 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0124766 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.012345 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0122927 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0122433 |
| PAIP1 | poly(A) binding protein interacting protein 1 | 0.0121933 |
| RPS7 | ribosomal protein S7 | 0.0121927 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0121802 |
| CENPE | centromere protein E, 312kDa | 0.012162 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0120104 |
| IFNAR2 | interferon (alpha, beta and omega) receptor 2 | 0.0119903 |
| GNL2 | guanine nucleotide binding protein-like 2 (nucleolar) | 0.0118817 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0118222 |
| XIAP | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase | 0.0118112 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.0116245 |
| TMEM41B | transmembrane protein 41B | 0.0115371 |
| SKIL | SKI-like proto-oncogene | 0.0115297 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.0115185 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.011482 |
| AURKA | aurora kinase A | 0.011429 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0114279 |
| SLC35F5 | solute carrier family 35, member F5 | 0.0113925 |
| FOSL1 | FOS-like antigen 1 | 0.0113162 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0113091 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.0112564 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.165029 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.149805 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.135542 |
| FTL | ferritin, light polypeptide | -0.124847 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.122332 |
| TXNRD1 | thioredoxin reductase 1 | -0.092512 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0829717 |
| RPL19 | ribosomal protein L19 | -0.0828463 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0718851 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0717939 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0687309 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0627947 |
| ERBIN | erbb2 interacting protein | -0.0623288 |
| TPD52 | tumor protein D52 | -0.0549211 |
| PARD3 | par-3 family cell polarity regulator | -0.0538871 |
| NRG1 | neuregulin 1 | -0.0533472 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0533141 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0508506 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0501752 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.049455 |
| RBM39 | RNA binding motif protein 39 | -0.0492064 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0481735 |
| DOCK4 | dedicator of cytokinesis 4 | -0.047631 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0470356 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0469804 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0459139 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0458176 |
| PTK2 | protein tyrosine kinase 2 | -0.0454894 |
| AHNAK | AHNAK nucleoprotein | -0.0442315 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0437747 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0430424 |
| WDR43 | WD repeat domain 43 | -0.0429133 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0416741 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0414356 |
| YBX1 | Y box binding protein 1 | -0.0410993 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0409765 |
| FMNL2 | formin-like 2 | -0.0391809 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0388194 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0386792 |
| MT2A | metallothionein 2A | -0.0382749 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0369981 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0367979 |
| USP3 | ubiquitin specific peptidase 3 | -0.0366926 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0365479 |
| APP | amyloid beta (A4) precursor protein | -0.0364408 |
| IER3 | immediate early response 3 | -0.0361663 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.035703 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0354392 |
| RPL4 | ribosomal protein L4 | -0.0349026 |
| ACTG1 | actin gamma 1 | -0.0348523 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0346892 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0342582 |
| ECT2 | epithelial cell transforming 2 | -0.0341421 |
| RPL36 | ribosomal protein L36 | -0.0338772 |
| FLNB | filamin B, beta | -0.0337117 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.032995 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0328851 |
| RHEB | Ras homolog enriched in brain | -0.0326175 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0312083 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0311945 |
| RPS25 | ribosomal protein S25 | -0.0311273 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0306685 |
| RCC1 | regulator of chromosome condensation 1 | -0.0305189 |
| SVIL | supervillin | -0.0303161 |
| HDAC9 | histone deacetylase 9 | -0.0302668 |
| UTRN | utrophin | -0.0302504 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0299834 |
| RPS21 | ribosomal protein S21 | -0.0298621 |
| PDE8A | phosphodiesterase 8A | -0.0298572 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0297604 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0294629 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0294396 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0294299 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.029266 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0290784 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0289921 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0286418 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.028591 |
| EWSR1 | EWS RNA-binding protein 1 | -0.0284964 |
| S100A10 | S100 calcium binding protein A10 | -0.0284568 |
| GNAS | GNAS complex locus | -0.0281905 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.027801 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0271516 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0269577 |
| RPS5 | ribosomal protein S5 | -0.0264385 |
| SIK3 | SIK family kinase 3 | -0.02618 |
| CFAP73 | cilia and flagella associated protein 73 | -0.0261738 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0259606 |
| NTN4 | netrin 4 | -0.0258847 |
| ANXA2 | annexin A2 | -0.0258126 |
| SMAD2 | SMAD family member 2 | -0.0250577 |
| GRAMD1B | GRAM domain containing 1B | -0.0250435 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0250288 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0248555 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0245407 |
| RPS29 | ribosomal protein S29 | -0.0244388 |
| RPS19 | ribosomal protein S19 | -0.0243135 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0242072 |
| RPLP1 | ribosomal protein, large, P1 | -0.0241514 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0240649 |
