Canagliflozin (hemihydrate)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin (hemihydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.12416
RPS6 ribosomal protein S6 0.0757421
NAMPT nicotinamide phosphoribosyltransferase 0.0752435
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0685642
PRRC2C proline-rich coiled-coil 2C 0.0624866
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0559726
VIM vimentin 0.0553749
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.053088
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0527472
KMT2E lysine (K)-specific methyltransferase 2E 0.052684
PTBP3 polypyrimidine tract binding protein 3 0.0524939
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0515225
FMNL2 formin-like 2 0.0501671
RPS12 ribosomal protein S12 0.0489179
VGF VGF nerve growth factor inducible 0.0487397
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0484961
SYT1 synaptotagmin I 0.0484132
KMT2C lysine (K)-specific methyltransferase 2C 0.0472628
CCNY cyclin Y 0.046984
EZR ezrin 0.0463507
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0461362
JMJD1C jumonji domain containing 1C 0.0460398
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0451484
PTGES2 prostaglandin E synthase 2 0.0450019
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0449808
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0444639
NAP1L1 nucleosome assembly protein 1-like 1 0.044191
GOLGA4 golgin A4 0.0441325
GPHN gephyrin 0.0440669
MT2A metallothionein 2A 0.043634
TRIO trio Rho guanine nucleotide exchange factor 0.0432147
ZNF292 zinc finger protein 292 0.0422355
GMDS GDP-mannose 4,6-dehydratase 0.042223
RPL12 ribosomal protein L12 0.0418938
PTMA prothymosin, alpha 0.0416576
NF1 neurofibromin 1 0.0406587
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.039219
KDM5B lysine (K)-specific demethylase 5B 0.0386092
CCDC88A coiled-coil domain containing 88A 0.0384253
RPLP1 ribosomal protein, large, P1 0.0377366
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0372725
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0366002
GLS2 glutaminase 2 (liver, mitochondrial) 0.0362184
MAML2 mastermind-like 2 (Drosophila) 0.0353777
OXR1 oxidation resistance 1 0.0353294
LAMA4 laminin, alpha 4 0.0352312
NCKAP1 NCK-associated protein 1 0.0348621
ARHGAP26 Rho GTPase activating protein 26 0.0347984
NKD1 naked cuticle homolog 1 (Drosophila) 0.0345711
ANO6 anoctamin 6 0.0344328
RPL31 ribosomal protein L31 0.0344177
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0339551
RPL11 ribosomal protein L11 0.0337454
TRA2A transformer 2 alpha homolog (Drosophila) 0.0337058
SND1 staphylococcal nuclease and tudor domain containing 1 0.0328537
CXCL8 chemokine (C-X-C motif) ligand 8 0.0328387
ERRFI1 ERBB receptor feedback inhibitor 1 0.0328304
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.0324635
ANKRD17 ankyrin repeat domain 17 0.0324591
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.031718
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0315332
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0314446
AKAP12 A kinase (PRKA) anchor protein 12 0.0314311
MSI2 musashi RNA-binding protein 2 0.0313697
STC1 stanniocalcin 1 0.0312739
DIAPH2 diaphanous-related formin 2 0.0312729
CSNK1A1 casein kinase 1, alpha 1 0.0311891
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0310848
PEG10 paternally expressed 10 0.0308285
SCAF8 SR-related CTD-associated factor 8 0.0305979
SLC38A2 solute carrier family 38, member 2 0.0298046
RAB7A RAB7A, member RAS oncogene family 0.0297769
WAC WW domain containing adaptor with coiled-coil 0.0296253
ATP11B ATPase, class VI, type 11B 0.0295779
OSBPL8 oxysterol binding protein-like 8 0.0295438
LCORL ligand dependent nuclear receptor corepressor-like 0.029455
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0294457
HMGA2 high mobility group AT-hook 2 0.0294069
PDIA3 protein disulfide isomerase family A, member 3 0.028965
SQSTM1 sequestosome 1 0.0289637
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.028911
ADAM17 ADAM metallopeptidase domain 17 0.0286149
RBM39 RNA binding motif protein 39 0.0285364
RPL26 ribosomal protein L26 0.0284769
RBM25 RNA binding motif protein 25 0.0284524
TPR translocated promoter region, nuclear basket protein 0.0283466
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0283464
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0282161
RTN4 reticulon 4 0.0281016
TOP2B topoisomerase (DNA) II beta 180kDa 0.0280564
JUN jun proto-oncogene 0.0279342
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0278766
HP1BP3 heterochromatin protein 1, binding protein 3 0.0276905
PDE8A phosphodiesterase 8A 0.0276376
ALCAM activated leukocyte cell adhesion molecule 0.0274272
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.0272975
VMP1 vacuole membrane protein 1 0.0272697
KDM5A lysine (K)-specific demethylase 5A 0.0271963
NUP153 nucleoporin 153kDa 0.0271704
RABGAP1L RAB GTPase activating protein 1-like 0.0269681

decreased expression

Symbol Name Standardized Value
GRB10 growth factor receptor-bound protein 10 -0.13222
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.126093
LMO7 LIM domain 7 -0.109002
LAMC2 laminin, gamma 2 -0.103581
SAMD4A sterile alpha motif domain containing 4A -0.0960449
MYO1E myosin IE -0.0929582
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0897357
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0889631
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0870339
MUC16 mucin 16, cell surface associated -0.0855088
ATOSA atos homolog A -0.083768
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0829708
BACE2 beta-site APP-cleaving enzyme 2 -0.0787063
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0744759
ANTXR2 anthrax toxin receptor 2 -0.0737511
PDE4D phosphodiesterase 4D, cAMP-specific -0.0726751
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0689251
KYNU kynureninase -0.0674537
FN1 fibronectin 1 -0.0666262
CEMIP cell migration inducing protein, hyaluronan binding -0.0662934
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.066071
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0652428
TM4SF1 transmembrane 4 L six family member 1 -0.0609447
PLAUR plasminogen activator, urokinase receptor -0.0555357
OSMR oncostatin M receptor -0.0555071
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0536408
POTEF POTE ankyrin domain family, member F -0.0535664
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0534874
AKAP13 A kinase (PRKA) anchor protein 13 -0.053404
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0529827
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0526276
PTPRM protein tyrosine phosphatase, receptor type, M -0.0524893
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0517975
ABHD17C abhydrolase domain containing 17C -0.0517156
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0511994
ARHGAP21 Rho GTPase activating protein 21 -0.0507855
TMCC3 transmembrane and coiled-coil domain family 3 -0.0506488
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.050472
SPNS2 spinster homolog 2 (Drosophila) -0.049976
RBM47 RNA binding motif protein 47 -0.0481159
PPARD peroxisome proliferator-activated receptor delta -0.0470541
ZNF185 zinc finger protein 185 (LIM domain) -0.0464737
RNF213 ring finger protein 213 -0.0461909
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0448177
ESYT2 extended synaptotagmin-like protein 2 -0.0435385
STEAP4 STEAP family member 4 -0.0430072
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0428594
LIMCH1 LIM and calponin homology domains 1 -0.0427528
ITPRID2 ITPR interacting domain containing 2 -0.0420514
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0409623
IGFBP3 insulin-like growth factor binding protein 3 -0.0403681
THRB thyroid hormone receptor, beta -0.0400036
ANXA2 annexin A2 -0.0396938
SLMAP sarcolemma associated protein -0.0393203
KIF13B kinesin family member 13B -0.0391692
CDCP1 CUB domain containing protein 1 -0.039057
TBC1D22A TBC1 domain family, member 22A -0.0387848
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0387026
NPEPPS aminopeptidase puromycin sensitive -0.0379195
MUC13 mucin 13, cell surface associated -0.0376944
IGF1R insulin-like growth factor 1 receptor -0.0375346
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0373221
BASP1 brain abundant, membrane attached signal protein 1 -0.037022
EXT1 exostosin glycosyltransferase 1 -0.0369436
INTS6 integrator complex subunit 6 -0.0369162
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0368903
PRDM1 PR domain containing 1, with ZNF domain -0.0363356
SPDYA speedy/RINGO cell cycle regulator family member A -0.0362649
CP ceruloplasmin (ferroxidase) -0.0362127
TPCN1 two pore segment channel 1 -0.0354516
DLG1 discs, large homolog 1 (Drosophila) -0.0351607
BZW1 basic leucine zipper and W2 domains 1 -0.0348633
GRAMD1B GRAM domain containing 1B -0.0345833
ZNF217 zinc finger protein 217 -0.0336644
CAPN2 calpain 2, (m/II) large subunit -0.0332442
TNRC18 trinucleotide repeat containing 18 -0.0330272
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0327203
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.0325485
GLIS3 GLIS family zinc finger 3 -0.0325084
GCC2 GRIP and coiled-coil domain containing 2 -0.0324732
TMEM87A transmembrane protein 87A -0.0323236
AK1 adenylate kinase 1 -0.0322751
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0320708
LAMB3 laminin, beta 3 -0.0318344
SCEL sciellin -0.0317734
SMOC1 SPARC related modular calcium binding 1 -0.0316904
VCAN versican -0.03162
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0315245
DENND2C DENN/MADD domain containing 2C -0.031435
BMAL2 basic helix-loop-helix ARNT like 2 -0.0310585
EXOC6B exocyst complex component 6B -0.0308678
PRKCSH protein kinase C substrate 80K-H -0.0307018
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0303624
MYO5C myosin VC -0.0301925
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0300653
ZMYND8 zinc finger, MYND-type containing 8 -0.0300143
MACC1 metastasis associated in colon cancer 1 -0.0299036
SHB Src homology 2 domain containing adaptor protein B -0.0298225
ADNP activity-dependent neuroprotector homeobox -0.0295404
LPP LIM domain containing preferred translocation partner in lipoma -0.029504