| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0585633 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0393821 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0392215 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0390142 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.037735 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0341748 |
| EGR1 | early growth response 1 | 0.0334497 |
| ANO6 | anoctamin 6 | 0.0327739 |
| VMP1 | vacuole membrane protein 1 | 0.0312375 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0306807 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0290187 |
| COPA | coatomer protein complex, subunit alpha | 0.0279378 |
| PCBP2 | poly(rC) binding protein 2 | 0.0267531 |
| MCL1 | myeloid cell leukemia 1 | 0.026496 |
| EXOC6B | exocyst complex component 6B | 0.0262273 |
| JMJD1C | jumonji domain containing 1C | 0.024781 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0245869 |
| RPS7 | ribosomal protein S7 | 0.0243044 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0242957 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0242132 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0233744 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0230661 |
| MKI67 | marker of proliferation Ki-67 | 0.0229994 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0223237 |
| MKRN1 | makorin ring finger protein 1 | 0.0219094 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0215649 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0210058 |
| MAN1A2 | mannosidase, alpha, class 1A, member 2 | 0.0209396 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.0208957 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0202073 |
| KMT5B | lysine methyltransferase 5B | 0.0199612 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0194584 |
| NUP58 | nucleoporin 58 | 0.0194414 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0186878 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0184238 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0175545 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0175313 |
| TPM3 | tropomyosin 3 | 0.0172894 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0170476 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0169676 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0169213 |
| MSN | moesin | 0.0169015 |
| NABP1 | nucleic acid binding protein 1 | 0.0167526 |
| FLNA | filamin A, alpha | 0.0167051 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0162677 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.016125 |
| FERMT2 | fermitin family member 2 | 0.0159778 |
| DNAJC21 | DnaJ (Hsp40) homolog, subfamily C, member 21 | 0.0158712 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0158479 |
| R3HDM2 | R3H domain containing 2 | 0.0157644 |
| HYOU1 | hypoxia up-regulated 1 | 0.0156644 |
| LEMD3 | LEM domain containing 3 | 0.0156395 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0152742 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0151461 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.015045 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0149704 |
| GOLGA4 | golgin A4 | 0.0149151 |
| KIF2A | kinesin heavy chain member 2A | 0.0149008 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | 0.0148168 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0148075 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0147979 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0147808 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0147367 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0146308 |
| SET | SET nuclear proto-oncogene | 0.0146231 |
| NCKAP1 | NCK-associated protein 1 | 0.0145471 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0144399 |
| PITPNB | phosphatidylinositol transfer protein, beta | 0.014283 |
| UBE2V2 | ubiquitin-conjugating enzyme E2 variant 2 | 0.0142115 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0141061 |
| INTS6 | integrator complex subunit 6 | 0.013964 |
| CDK19 | cyclin-dependent kinase 19 | 0.013822 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0137732 |
| SQSTM1 | sequestosome 1 | 0.0134943 |
| ATP13A3 | ATPase type 13A3 | 0.0134498 |
| TAF1 | TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa | 0.0134264 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0134096 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0133316 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0132666 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0132574 |
| NBEAL1 | neurobeachin-like 1 | 0.0132413 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.013152 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0131381 |
| UBAP1 | ubiquitin associated protein 1 | 0.0129773 |
| ANGPTL4 | angiopoietin-like 4 | 0.0128777 |
| FOSL2 | FOS-like antigen 2 | 0.0128261 |
| SERINC1 | serine incorporator 1 | 0.0127946 |
| MYO9A | myosin IXA | 0.0127819 |
| PDS5B | PDS5 cohesin associated factor B | 0.012761 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0127383 |
| GON4L | gon-4-like (C. elegans) | 0.0127121 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0126115 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0125602 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0125497 |
| IGF2 | insulin-like growth factor 2 | 0.0125461 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.0125008 |
| XIAP | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase | 0.0124426 |
| KIF5B | kinesin family member 5B | 0.01242 |
| TBK1 | TANK-binding kinase 1 | 0.0123489 |
| ZNF207 | zinc finger protein 207 | 0.0122812 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.332121 |
| TMSB10 | thymosin beta 10 | -0.149596 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.148873 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0937781 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0912644 |
| PTMA | prothymosin, alpha | -0.0850225 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0800236 |
| ACTG1 | actin gamma 1 | -0.0727978 |
| RPL35A | ribosomal protein L35a | -0.0720295 |
| RPS21 | ribosomal protein S21 | -0.0691329 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0665852 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0575174 |
| AHNAK | AHNAK nucleoprotein | -0.0507812 |
| VIM | vimentin | -0.0505062 |
| GNAS | GNAS complex locus | -0.0483468 |
| RPL19 | ribosomal protein L19 | -0.0476092 |
| DEK | DEK proto-oncogene | -0.0458517 |
| TPI1 | triosephosphate isomerase 1 | -0.0452749 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0450376 |
| RPS19 | ribosomal protein S19 | -0.0448369 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0445441 |
| RPS8 | ribosomal protein S8 | -0.0441883 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0420278 |
| YBX3 | Y box binding protein 3 | -0.0412309 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0412013 |
| OSMR | oncostatin M receptor | -0.0401605 |
| ADAR | adenosine deaminase, RNA-specific | -0.0400796 |
| ATP11A | ATPase, class VI, type 11A | -0.0400286 |
| RPS27A | ribosomal protein S27a | -0.039429 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0393899 |
| RPL12 | ribosomal protein L12 | -0.0392818 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0388007 |
| RPL38 | ribosomal protein L38 | -0.0382114 |
| RPL32 | ribosomal protein L32 | -0.0368493 |
| MT2A | metallothionein 2A | -0.0365665 |
| RPL23 | ribosomal protein L23 | -0.0365499 |
| PGK1 | phosphoglycerate kinase 1 | -0.0364642 |
| RPL34 | ribosomal protein L34 | -0.0354364 |
| RPS29 | ribosomal protein S29 | -0.0353636 |
| RPLP2 | ribosomal protein, large, P2 | -0.0349639 |
| RPS15 | ribosomal protein S15 | -0.0346697 |
| RPS4X | ribosomal protein S4, X-linked | -0.0343711 |
| GLO1 | glyoxalase I | -0.0341093 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0338953 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0332935 |
| RPS10 | ribosomal protein S10 | -0.0332868 |
| LDHB | lactate dehydrogenase B | -0.0329568 |
| RACK1 | receptor for activated C kinase 1 | -0.0328205 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0328047 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.032766 |
| RPL37 | ribosomal protein L37 | -0.0326941 |
| RPL36 | ribosomal protein L36 | -0.0326907 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.032544 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0325018 |
| CCND2 | cyclin D2 | -0.0323191 |
| RPL37A | ribosomal protein L37a | -0.0320216 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0318878 |
| RPS24 | ribosomal protein S24 | -0.0318655 |
| ZNF217 | zinc finger protein 217 | -0.0318612 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0314023 |
| PHIP | pleckstrin homology domain interacting protein | -0.0312363 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0305633 |
| CCND1 | cyclin D1 | -0.0303648 |
| HLA-B | major histocompatibility complex, class I, B | -0.0303115 |
| H1-0 | H1.0 linker histone | -0.0302728 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0301912 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0298804 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.029831 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0294446 |
| RBM39 | RNA binding motif protein 39 | -0.0293077 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0291204 |
| PFN1 | profilin 1 | -0.0289226 |
| RPL11 | ribosomal protein L11 | -0.028667 |
| PDE10A | phosphodiesterase 10A | -0.0283257 |
| FUS | FUS RNA binding protein | -0.0282725 |
| POTEF | POTE ankyrin domain family, member F | -0.0282356 |
| RPLP1 | ribosomal protein, large, P1 | -0.0281505 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0280455 |
| GRAMD1B | GRAM domain containing 1B | -0.0279511 |
| RPL8 | ribosomal protein L8 | -0.0278063 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0277471 |
| RPL4 | ribosomal protein L4 | -0.0275494 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0273518 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0272428 |
| UBB | ubiquitin B | -0.0267905 |
| RPS3 | ribosomal protein S3 | -0.0266385 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0266304 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0265412 |
| HMGA1 | high mobility group AT-hook 1 | -0.0263124 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0259394 |
| RPL26 | ribosomal protein L26 | -0.025913 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0258446 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.025437 |
| TUBB | tubulin, beta class I | -0.0252386 |
| UBC | ubiquitin C | -0.0246091 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0246052 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0244456 |
| CDK12 | cyclin-dependent kinase 12 | -0.0243437 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0237788 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0234888 |
