Canagliflozin (hemihydrate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin (hemihydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.127348
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.120493
HMGB2 high mobility group box 2 0.0861186
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0707891
FTL ferritin, light polypeptide 0.0587168
BHLHE40 basic helix-loop-helix family, member e40 0.0552705
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0519816
FTH1 ferritin, heavy polypeptide 1 0.0469749
GPBP1 GC-rich promoter binding protein 1 0.0444381
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0444011
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.043283
RPS3 ribosomal protein S3 0.0430319
DDIT4 DNA-damage-inducible transcript 4 0.0429672
UBA6 ubiquitin-like modifier activating enzyme 6 0.0424126
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0415189
RPS12 ribosomal protein S12 0.0391473
RNF145 ring finger protein 145 0.0370868
BZW1 basic leucine zipper and W2 domains 1 0.0361
APLP2 amyloid beta (A4) precursor-like protein 2 0.0359195
MT2A metallothionein 2A 0.0352971
PTMA prothymosin, alpha 0.0348869
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0338456
HILPDA hypoxia inducible lipid droplet-associated 0.0334537
TMF1 TATA element modulatory factor 1 0.0331541
PDIA3 protein disulfide isomerase family A, member 3 0.0325769
PRRC2C proline-rich coiled-coil 2C 0.0323813
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0317483
NUP58 nucleoporin 58 0.0311348
MYO6 myosin VI 0.0301224
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0300053
ALCAM activated leukocyte cell adhesion molecule 0.0300026
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0294471
HYOU1 hypoxia up-regulated 1 0.0286597
MSN moesin 0.0279741
RPS7 ribosomal protein S7 0.0272779
CD46 CD46 molecule, complement regulatory protein 0.0272672
KMT2E lysine (K)-specific methyltransferase 2E 0.0270897
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0268908
YTHDC1 YTH domain containing 1 0.026814
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0267029
CSDE1 cold shock domain containing E1, RNA-binding 0.0266926
AFDN afadin, adherens junction formation factor 0.0257824
SET SET nuclear proto-oncogene 0.0248975
TOP1 topoisomerase (DNA) I 0.0246577
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0245455
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 0.0245027
RPL21 ribosomal protein L21 0.0232143
KTN1 kinectin 1 (kinesin receptor) 0.0232027
SLMAP sarcolemma associated protein 0.0228017
LDHA lactate dehydrogenase A 0.022546
S100A6 S100 calcium binding protein A6 0.0224366
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0224019
TPM3 tropomyosin 3 0.0222516
MYH9 myosin, heavy chain 9, non-muscle 0.0221083
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0220776
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0220595
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0217575
MKRN1 makorin ring finger protein 1 0.0215299
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0212448
RPS17 ribosomal protein S17 0.021095
CD9 CD9 molecule 0.0204814
KDM6A lysine (K)-specific demethylase 6A 0.0202638
ERRFI1 ERBB receptor feedback inhibitor 1 0.0202546
PCBP2 poly(rC) binding protein 2 0.0199999
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.019798
RYK receptor-like tyrosine kinase 0.0195561
VEZT vezatin, adherens junctions transmembrane protein 0.0193455
B2M beta-2-microglobulin 0.019169
RAB6A RAB6A, member RAS oncogene family 0.0191325
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0191013
DSTN destrin (actin depolymerizing factor) 0.0190927
ITCH itchy E3 ubiquitin protein ligase 0.0190187
NCKAP1 NCK-associated protein 1 0.0186921
CBX3 chromobox homolog 3 0.018541
FAM13A family with sequence similarity 13, member A 0.0182827
HP1BP3 heterochromatin protein 1, binding protein 3 0.0182765
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0182511
GOLGA4 golgin A4 0.0182493
SRSF11 serine/arginine-rich splicing factor 11 0.0181785
SRRM1 serine/arginine repetitive matrix 1 0.018147
FLNA filamin A, alpha 0.0179154
HDGF hepatoma-derived growth factor 0.0177625
HMGN2 high mobility group nucleosomal binding domain 2 0.0176916
MBNL1 muscleblind-like splicing regulator 1 0.0175835
SRRM2 serine/arginine repetitive matrix 2 0.0174192
PNISR PNN-interacting serine/arginine-rich protein 0.0173642
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0173446
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0172934
PAPOLA poly(A) polymerase alpha 0.0171749
PABPN1 poly(A) binding protein, nuclear 1 0.017143
RTN4 reticulon 4 0.0171346
CALR calreticulin 0.016998
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0168193
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0167614
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0167234
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0164905
FERMT2 fermitin family member 2 0.0164775
ANXA1 annexin A1 0.0161699
CD109 CD109 molecule 0.0160805
CSNK1A1 casein kinase 1, alpha 1 0.0160796

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.487677
ACTG1 actin gamma 1 -0.249456
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.158569
RPL35A ribosomal protein L35a -0.153115
UBC ubiquitin C -0.126998
S100A10 S100 calcium binding protein A10 -0.107653
TM4SF1 transmembrane 4 L six family member 1 -0.0956031
KRT7 keratin 7, type II -0.0875393
RPL34 ribosomal protein L34 -0.085771
RPL8 ribosomal protein L8 -0.0798944
FN1 fibronectin 1 -0.079644
TMSB10 thymosin beta 10 -0.0792765
NDRG1 N-myc downstream regulated 1 -0.0723805
TPT1 tumor protein, translationally-controlled 1 -0.0677446
POTEF POTE ankyrin domain family, member F -0.067638
AHNAK AHNAK nucleoprotein -0.0647648
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0630783
TMSB4X thymosin beta 4, X-linked -0.0620697
CD2AP CD2-associated protein -0.0601285
RPS23 ribosomal protein S23 -0.058916
CCND1 cyclin D1 -0.0573013
LPP LIM domain containing preferred translocation partner in lipoma -0.056589
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0539106
IGFBP3 insulin-like growth factor binding protein 3 -0.05315
LMO7 LIM domain 7 -0.0512306
EIF1 eukaryotic translation initiation factor 1 -0.0505468
LY6E lymphocyte antigen 6 complex, locus E -0.0479227
EXT1 exostosin glycosyltransferase 1 -0.0473285
DEK DEK proto-oncogene -0.042368
RPLP1 ribosomal protein, large, P1 -0.0422116
MDK midkine (neurite growth-promoting factor 2) -0.0416223
IFI16 interferon, gamma-inducible protein 16 -0.040723
TSC22D2 TSC22 domain family, member 2 -0.0388803
TRIO trio Rho guanine nucleotide exchange factor -0.038493
SDC4 syndecan 4 -0.0384908
ANXA2 annexin A2 -0.0377562
TMEM263 transmembrane protein 263 -0.0376977
LOC112694756 uncharaterized LOC112694756 -0.0375183
RPS15 ribosomal protein S15 -0.0375068
RPL32 ribosomal protein L32 -0.0366805
GRB10 growth factor receptor-bound protein 10 -0.0366004
CD63 CD63 molecule -0.0358418
RPS24 ribosomal protein S24 -0.0358166
DSG2 desmoglein 2 -0.0356862
SQSTM1 sequestosome 1 -0.0356341
KRT8 keratin 8, type II -0.0348687
H1-0 H1.0 linker histone -0.0341396
PTK2 protein tyrosine kinase 2 -0.0339231
RRBP1 ribosome binding protein 1 -0.0338808
PGK1 phosphoglycerate kinase 1 -0.0338554
RPS5 ribosomal protein S5 -0.0337038
RPS19 ribosomal protein S19 -0.0334791
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0313161
RPL19 ribosomal protein L19 -0.0312525
RPL23 ribosomal protein L23 -0.0312336
SAMD4A sterile alpha motif domain containing 4A -0.0311989
ARF1 ADP-ribosylation factor 1 -0.0306505
RPS21 ribosomal protein S21 -0.0303235
RPS11 ribosomal protein S11 -0.0301568
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0294358
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0292692
TMEM123 transmembrane protein 123 -0.0288938
RHOA ras homolog family member A -0.0288524
CTSB cathepsin B -0.0283693
F11R F11 receptor -0.0281839
OAZ1 ornithine decarboxylase antizyme 1 -0.0281282
G0S2 G0/G1 switch 2 -0.0276998
MX2 MX dynamin-like GTPase 2 -0.0275898
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0275086
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0273711
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0272112
GNAS GNAS complex locus -0.0271841
LIMCH1 LIM and calponin homology domains 1 -0.0269962
FBXO32 F-box protein 32 -0.0268838
EPCAM epithelial cell adhesion molecule -0.0268649
RPL14 ribosomal protein L14 -0.0267835
RPS6 ribosomal protein S6 -0.0267207
RPS29 ribosomal protein S29 -0.026518
RPL28 ribosomal protein L28 -0.0264014
RPL11 ribosomal protein L11 -0.0263798
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0263387
ZBTB20 zinc finger and BTB domain containing 20 -0.0263335
TAPBP TAP binding protein (tapasin) -0.0263074
CCNI cyclin I -0.0261164
HLA-B major histocompatibility complex, class I, B -0.0260832
RAD21 RAD21 homolog (S. pombe) -0.025943
C15ORF48 chromosome 15 open reading frame 48 -0.0255412
RPL4 ribosomal protein L4 -0.0253677
SP100 SP100 nuclear antigen -0.0252922
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0246701
SEC31A SEC31 homolog A (S. cerevisiae) -0.0245589
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0240496
STEAP4 STEAP family member 4 -0.0237252
ASTN2 astrotactin 2 -0.0235059
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0233869
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0233441
RNF213 ring finger protein 213 -0.0230004
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0229208
TXNRD1 thioredoxin reductase 1 -0.0226508
SVIL supervillin -0.0225605