Canagliflozin (hemihydrate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin (hemihydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GDA guanine deaminase 0.0727649
CD109 CD109 molecule 0.0599087
TXNRD1 thioredoxin reductase 1 0.0547563
NAMPT nicotinamide phosphoribosyltransferase 0.0535975
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.050202
FTH1 ferritin, heavy polypeptide 1 0.0393926
ZEB2 zinc finger E-box binding homeobox 2 0.0366205
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0338128
KYNU kynureninase 0.0330298
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0325455
CENPF centromere protein F, 350/400kDa 0.0321369
GRAMD1B GRAM domain containing 1B 0.0314404
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0300894
RTN4 reticulon 4 0.02924
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0290989
MYOF myoferlin 0.0282576
NPAS2 neuronal PAS domain protein 2 0.0279312
MKI67 marker of proliferation Ki-67 0.027174
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0266709
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0264848
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0263763
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0262155
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0252795
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0249621
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0245754
MCL1 myeloid cell leukemia 1 0.0244171
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0241362
VMP1 vacuole membrane protein 1 0.0241361
MFF mitochondrial fission factor 0.0241138
PRRC2C proline-rich coiled-coil 2C 0.0239308
ELL2 elongation factor, RNA polymerase II, 2 0.023838
SAMD4A sterile alpha motif domain containing 4A 0.0237248
DDIT4 DNA-damage-inducible transcript 4 0.0228674
TGFBI transforming growth factor, beta-induced, 68kDa 0.022805
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0226638
SFPQ splicing factor proline/glutamine-rich 0.0225524
MSN moesin 0.0220816
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0217886
CTSC cathepsin C 0.0212971
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0206762
TMX4 thioredoxin-related transmembrane protein 4 0.0204917
CARD16 caspase recruitment domain family, member 16 0.0203489
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.019254
AVL9 AVL9 homolog (S. cerevisiase) 0.0192124
SET SET nuclear proto-oncogene 0.0187929
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0185191
RAB3B RAB3B, member RAS oncogene family 0.0177786
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0176506
PTGR1 prostaglandin reductase 1 0.0175557
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.017166
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0169386
DGKD diacylglycerol kinase, delta 130kDa 0.0168897
TRIO trio Rho guanine nucleotide exchange factor 0.0162117
PCBP2 poly(rC) binding protein 2 0.0158573
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.015778
KTN1 kinectin 1 (kinesin receptor) 0.0156768
BMERB1 bMERB domain containing 1 0.0146188
FLNB filamin B, beta 0.0144413
GIGYF2 GRB10 interacting GYF protein 2 0.0143657
SKAP2 src kinase associated phosphoprotein 2 0.014328
DIAPH3 diaphanous-related formin 3 0.014286
KPNB1 karyopherin (importin) beta 1 0.0142762
ENO1 enolase 1, (alpha) 0.0142077
CUL4A cullin 4A 0.0140604
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0139424
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.013942
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0138283
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0137166
ITPRID2 ITPR interacting domain containing 2 0.0137014
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0135385
SMC4 structural maintenance of chromosomes 4 0.0132572
KIF5B kinesin family member 5B 0.0132277
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0131652
STC2 stanniocalcin 2 0.0130891
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0129643
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0129165
RBM25 RNA binding motif protein 25 0.01277
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0126314
SH3KBP1 SH3-domain kinase binding protein 1 0.0125876
MATR3 matrin 3 0.0124483
PTEN phosphatase and tensin homolog 0.012373
RAI1 retinoic acid induced 1 0.0123248
CSNK1A1 casein kinase 1, alpha 1 0.0122688
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0120564
HLA-A major histocompatibility complex, class I, A 0.0119278
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0118201
IL1RAP interleukin 1 receptor accessory protein 0.0117148
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0114258
TARBP1 TAR (HIV-1) RNA binding protein 1 0.011425
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0113217
TMEM87A transmembrane protein 87A 0.0112942
PYGL phosphorylase, glycogen, liver 0.0111676
BCAR3 breast cancer anti-estrogen resistance 3 0.0110927
UGCG UDP-glucose ceramide glucosyltransferase 0.0109915
ZBTB43 zinc finger and BTB domain containing 43 0.0109829
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0109699
SPRED2 sprouty-related, EVH1 domain containing 2 0.0109647
ENAH enabled homolog (Drosophila) 0.0109526
NTN4 netrin 4 0.0109132
ARHGAP29 Rho GTPase activating protein 29 0.0108175

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.242707
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.159299
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.146677
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.135103
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.123984
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115598
CDH13 cadherin 13 -0.10275
FN1 fibronectin 1 -0.0994542
NALF1 NALCN channel auxiliary factor 1 -0.0613133
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0573463
PTPRM protein tyrosine phosphatase, receptor type, M -0.0560733
AUTS2 autism susceptibility candidate 2 -0.0556866
PDE10A phosphodiesterase 10A -0.0552285
DST dystonin -0.0551073
TPT1 tumor protein, translationally-controlled 1 -0.0545182
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0540341
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0529424
FTL ferritin, light polypeptide -0.0526954
TMSB10 thymosin beta 10 -0.0524716
PSD3 pleckstrin and Sec7 domain containing 3 -0.0524135
PRKN parkin RBR E3 ubiquitin protein ligase -0.0515272
CANX calnexin -0.0462969
ADGRD1 adhesion G protein-coupled receptor D1 -0.0432752
PTMA prothymosin, alpha -0.0410686
PRELID2 PRELI domain containing 2 -0.0381929
MAML3 mastermind-like 3 (Drosophila) -0.0374287
VCL vinculin -0.035504
LSAMP limbic system-associated membrane protein -0.0350706
DENND1A DENN/MADD domain containing 1A -0.0348436
RPL19 ribosomal protein L19 -0.0341555
RPL12 ribosomal protein L12 -0.0324029
SMOC1 SPARC related modular calcium binding 1 -0.0323392
RPLP1 ribosomal protein, large, P1 -0.0322213
RPL31 ribosomal protein L31 -0.0317518
RPS24 ribosomal protein S24 -0.0307219
INTS6 integrator complex subunit 6 -0.0298182
SOD2 superoxide dismutase 2, mitochondrial -0.0293759
NCKAP5 NCK-associated protein 5 -0.0289772
P3H2 prolyl 3-hydroxylase 2 -0.0284532
SMAD2 SMAD family member 2 -0.0273999
EXT1 exostosin glycosyltransferase 1 -0.0273724
RAD51B RAD51 paralog B -0.0272662
RPS8 ribosomal protein S8 -0.0269768
CUX1 cut-like homeobox 1 -0.0265005
FNDC3B fibronectin type III domain containing 3B -0.026379
PDIA4 protein disulfide isomerase family A, member 4 -0.0261291
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0260497
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0259825
AHNAK AHNAK nucleoprotein -0.0259816
RPL35A ribosomal protein L35a -0.0254721
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0248491
XYLT1 xylosyltransferase I -0.0246351
FMNL2 formin-like 2 -0.0244357
RPS6 ribosomal protein S6 -0.0238365
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0237867
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.023566
CHL1 cell adhesion molecule L1-like -0.0233435
TTC28 tetratricopeptide repeat domain 28 -0.0233354
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0231831
RPL26 ribosomal protein L26 -0.0228945
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0228097
NT5C2 5'-nucleotidase, cytosolic II -0.0226079
GLRX glutaredoxin (thioltransferase) -0.0224585
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0224064
WSB1 WD repeat and SOCS box containing 1 -0.0222929
CADM2 cell adhesion molecule 2 -0.0222187
RPS25 ribosomal protein S25 -0.0221219
RPS4X ribosomal protein S4, X-linked -0.0220645
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0218389
CAMTA1 calmodulin binding transcription activator 1 -0.0214406
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.021391
UBC ubiquitin C -0.0210009
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0208276
GPC6 glypican 6 -0.0208195
RPS3 ribosomal protein S3 -0.0207591
RPL34 ribosomal protein L34 -0.0206634
RPL4 ribosomal protein L4 -0.0206139
ACTG1 actin gamma 1 -0.0203253
S100A10 S100 calcium binding protein A10 -0.0202823
RPL37A ribosomal protein L37a -0.0201902
RPL38 ribosomal protein L38 -0.0199922
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0198825
ANTXR1 anthrax toxin receptor 1 -0.0195179
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0188393
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0187707
SOX6 SRY (sex determining region Y)-box 6 -0.0185839
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0183799
ATXN1 ataxin 1 -0.0182298
DOCK4 dedicator of cytokinesis 4 -0.0181995
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0181154
TENM3 teneurin transmembrane protein 3 -0.0180142
SDK1 sidekick cell adhesion molecule 1 -0.0180069
RPS29 ribosomal protein S29 -0.0179787
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0179219
WARS1 tryptophanyl-tRNA synthetase 1 -0.017902
HILPDA hypoxia inducible lipid droplet-associated -0.0178604
IGFBP3 insulin-like growth factor binding protein 3 -0.0178547
HLA-B major histocompatibility complex, class I, B -0.0178355
IGF1R insulin-like growth factor 1 receptor -0.0176395
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0171487