Canagliflozin (hemihydrate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

152 genes differentially expressed following the Canagliflozin (hemihydrate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.171051
TRIO trio Rho guanine nucleotide exchange factor 0.146721
FNDC3B fibronectin type III domain containing 3B 0.119344
NCOA3 nuclear receptor coactivator 3 0.112276
PDE4D phosphodiesterase 4D, cAMP-specific 0.111233
ATXN1 ataxin 1 0.109581
VMP1 vacuole membrane protein 1 0.10856
DST dystonin 0.0910875
SMYD3 SET and MYND domain containing 3 0.0837644
VIM vimentin 0.0814365
PDE10A phosphodiesterase 10A 0.0658314
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0651718
PRRC2C proline-rich coiled-coil 2C 0.0627504
KMT2C lysine (K)-specific methyltransferase 2C 0.061212
PTK2 protein tyrosine kinase 2 0.0587482
KDM5B lysine (K)-specific demethylase 5B 0.0557894
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0545659
ANXA2 annexin A2 0.0540621
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0521037
RPL23 ribosomal protein L23 0.0512014
NAP1L1 nucleosome assembly protein 1-like 1 0.0497111
RPS12 ribosomal protein S12 0.0486097
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0468765
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.045788
JMJD1C jumonji domain containing 1C 0.0387998
NAMPT nicotinamide phosphoribosyltransferase 0.0381819
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0358556
CANX calnexin 0.034349
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.032841
ZNF292 zinc finger protein 292 0.0310296
NRG3 neuregulin 3 0.0298309
DSCAM Down syndrome cell adhesion molecule 0.0290096
NPAS2 neuronal PAS domain protein 2 0.0282298
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0280856
KMT2E lysine (K)-specific methyltransferase 2E 0.0260163
MBD5 methyl-CpG binding domain protein 5 0.0259719
ACTN4 actinin, alpha 4 0.0259278
SETD5 SET domain containing 5 0.0248135
ERRFI1 ERBB receptor feedback inhibitor 1 0.0243617
SPAG9 sperm associated antigen 9 0.0238035
SBF2 SET binding factor 2 0.0225797
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0208421
RTN4 reticulon 4 0.0207842
GPC6 glypican 6 0.019481
TRA2A transformer 2 alpha homolog (Drosophila) 0.0187334
ACTG1 actin gamma 1 0.0184211
MAML3 mastermind-like 3 (Drosophila) 0.0178418
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0175162
ZFAND3 zinc finger, AN1-type domain 3 0.0173807
RPL31 ribosomal protein L31 0.0168051
ASPH aspartate beta-hydroxylase 0.0162943
IGFBP3 insulin-like growth factor binding protein 3 0.0157759
PRKCA protein kinase C, alpha 0.0153786
TBC1D22A TBC1 domain family, member 22A 0.015043
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0125984
RPS3 ribosomal protein S3 0.0120619
PRELID2 PRELI domain containing 2 0.011655
TPT1 tumor protein, translationally-controlled 1 0.0101651
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.00904164
MYOF myoferlin 0.0085625
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.00810308
LRP1B low density lipoprotein receptor-related protein 1B 0.00760949
CARD16 caspase recruitment domain family, member 16 0.00629989
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.00587345
MEF2A myocyte enhancer factor 2A 0.00449176
ARID1B AT rich interactive domain 1B (SWI1-like) 0.00364313
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.00360146
MT2A metallothionein 2A 0.00336779
CCNI cyclin I 0.00295516
OGA O-GlcNAcase 0.00164846
FTH1 ferritin, heavy polypeptide 1 0.0013272

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.339922
PTMA prothymosin, alpha -0.201671
FN1 fibronectin 1 -0.166304
NDRG1 N-myc downstream regulated 1 -0.157855
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122688
TMSB10 thymosin beta 10 -0.0976981
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0953958
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0951576
IGF2 insulin-like growth factor 2 -0.0887926
NKD1 naked cuticle homolog 1 (Drosophila) -0.0872819
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0799126
LMO7 LIM domain 7 -0.0746586
RACK1 receptor for activated C kinase 1 -0.0671386
PGK1 phosphoglycerate kinase 1 -0.0668041
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0640751
MAML2 mastermind-like 2 (Drosophila) -0.0635822
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0630994
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0606049
IGFBP5 insulin-like growth factor binding protein 5 -0.0593159
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0572851
UBC ubiquitin C -0.0555212
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0547208
PARD3 par-3 family cell polarity regulator -0.0534379
EEF2 eukaryotic translation elongation factor 2 -0.0504363
EGR1 early growth response 1 -0.0478334
MYO1E myosin IE -0.0454557
NUP58 nucleoporin 58 -0.0439518
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0408877
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0407097
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0405888
RPS13 ribosomal protein S13 -0.039739
SYT1 synaptotagmin I -0.0381692
MON2 MON2 homolog (S. cerevisiae) -0.0353505
CHD9 chromodomain helicase DNA binding protein 9 -0.0344268
RPLP2 ribosomal protein, large, P2 -0.0327993
SLC38A1 solute carrier family 38, member 1 -0.0326723
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.032535
COL19A1 collagen, type XIX, alpha 1 -0.0315007
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0309149
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0304855
INTS6 integrator complex subunit 6 -0.0303276
SLC38A2 solute carrier family 38, member 2 -0.0286429
LDHA lactate dehydrogenase A -0.0275927
ENO1 enolase 1, (alpha) -0.0266943
RPL37A ribosomal protein L37a -0.0255524
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -0.0253011
WAC WW domain containing adaptor with coiled-coil -0.0251175
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0240243
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0238158
SRPK2 SRSF protein kinase 2 -0.0229317
RPS27A ribosomal protein S27a -0.0228722
RLF rearranged L-myc fusion -0.0205629
ADAM10 ADAM metallopeptidase domain 10 -0.0203443
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.019279
PDLIM5 PDZ and LIM domain 5 -0.0187798
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0174388
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0171796
PTPRM protein tyrosine phosphatase, receptor type, M -0.016797
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0164861
FTL ferritin, light polypeptide -0.0158636
MYH9 myosin, heavy chain 9, non-muscle -0.0150332
ZBTB20 zinc finger and BTB domain containing 20 -0.01483
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0140182
RSRC2 arginine/serine-rich coiled-coil 2 -0.0129238
GOLGA4 golgin A4 -0.0119696
CMIP c-Maf inducing protein -0.0100215
PKM pyruvate kinase, muscle -0.00974528
EPS8 epidermal growth factor receptor pathway substrate 8 -0.00959668
PNISR PNN-interacting serine/arginine-rich protein -0.00947077
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.00786285
RPS6 ribosomal protein S6 -0.00623668
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.006109
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.00517787
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.00475782
RPL26 ribosomal protein L26 -0.00452871
AKAP9 A kinase (PRKA) anchor protein 9 -0.00368841
RABGAP1L RAB GTPase activating protein 1-like -0.00168783
FNIP1 folliculin interacting protein 1 -0.00101751
NAV2 neuron navigator 2 -9.51766E-4
RASA3 RAS p21 protein activator 3 -7.87122E-4
PDIA3 protein disulfide isomerase family A, member 3 -7.66011E-4