| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PEG10 | paternally expressed 10 | 0.0407482 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0367683 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0365626 |
| FTL | ferritin, light polypeptide | 0.0352737 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0336354 |
| WDR43 | WD repeat domain 43 | 0.0300431 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0285052 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0261185 |
| RPLP0 | ribosomal protein, large, P0 | 0.0258757 |
| MTF2 | metal response element binding transcription factor 2 | 0.0258307 |
| RPS12 | ribosomal protein S12 | 0.0238355 |
| RLF | rearranged L-myc fusion | 0.0237922 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0225559 |
| TLK1 | tousled-like kinase 1 | 0.0224101 |
| FN1 | fibronectin 1 | 0.0223688 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0223114 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.022281 |
| EFNA5 | ephrin-A5 | 0.021982 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0213988 |
| DCAF5 | DDB1 and CUL4 associated factor 5 | 0.0213666 |
| NBEAL1 | neurobeachin-like 1 | 0.0206715 |
| FBXO11 | F-box protein 11 | 0.0202841 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0195661 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | 0.0195351 |
| KLHDC10 | kelch domain containing 10 | 0.0191754 |
| KIF5B | kinesin family member 5B | 0.0190026 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.018961 |
| NDRG1 | N-myc downstream regulated 1 | 0.0189469 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0188607 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.0187305 |
| PFN1 | profilin 1 | 0.0186779 |
| RPS26 | ribosomal protein S26 | 0.0186683 |
| STC1 | stanniocalcin 1 | 0.0185607 |
| MRPS30 | mitochondrial ribosomal protein S30 | 0.018352 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0183465 |
| USP3 | ubiquitin specific peptidase 3 | 0.018292 |
| RPL13A | ribosomal protein L13a | 0.0179782 |
| TBC1D12 | TBC1 domain family, member 12 | 0.0179091 |
| RPS7 | ribosomal protein S7 | 0.0176929 |
| RPL28 | ribosomal protein L28 | 0.0173708 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0173282 |
| MTMR3 | myotubularin related protein 3 | 0.0171482 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0169445 |
| HMGN1 | high mobility group nucleosome binding domain 1 | 0.0169273 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0168789 |
| PDE10A | phosphodiesterase 10A | 0.016758 |
| MT2A | metallothionein 2A | 0.0166818 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0165285 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0163625 |
| RPS2 | ribosomal protein S2 | 0.0159156 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0158671 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0158569 |
| NOP58 | NOP58 ribonucleoprotein | 0.015849 |
| NUCB2 | nucleobindin 2 | 0.0156236 |
| RBM8A | RNA binding motif protein 8A | 0.0153528 |
| DYNC1I2 | dynein, cytoplasmic 1, intermediate chain 2 | 0.0152406 |
| PPP1R21 | protein phosphatase 1, regulatory subunit 21 | 0.0151541 |
| RNF13 | ring finger protein 13 | 0.0151061 |
| TKT | transketolase | 0.0150836 |
| DSTN | destrin (actin depolymerizing factor) | 0.0150701 |
| MYADM | myeloid-associated differentiation marker | 0.0150353 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0149484 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | 0.0148584 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.0148105 |
| VIRMA | vir like m6A methyltransferase associated | 0.0147045 |
| DIP2A | DIP2 disco-interacting protein 2 homolog A (Drosophila) | 0.0146919 |
| RPS6 | ribosomal protein S6 | 0.0146554 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0146523 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.014575 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0145531 |
| PAIP1 | poly(A) binding protein interacting protein 1 | 0.0145501 |
| PRELID3B | PRELI domain containing 3B | 0.0145104 |
| CIRSR | corepressor of RBPJ and splicing regulator | 0.0145089 |
| GMPS | guanine monphosphate synthase | 0.0144856 |
| PRPF6 | pre-mRNA processing factor 6 | 0.0142403 |
| PNN | pinin, desmosome associated protein | 0.0141638 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0141092 |
| ANXA1 | annexin A1 | 0.0140974 |
| TNPO3 | transportin 3 | 0.0140882 |
| HSF2 | heat shock transcription factor 2 | 0.0140705 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0140166 |
| RPL21 | ribosomal protein L21 | 0.0139764 |
| SMC6 | structural maintenance of chromosomes 6 | 0.013915 |
| TCEA1 | transcription elongation factor A (SII), 1 | 0.0138515 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0136511 |
| C1ORF52 | chromosome 1 open reading frame 52 | 0.0134659 |
| AAK1 | AP2 associated kinase 1 | 0.0134256 |
| CHMP5 | charged multivesicular body protein 5 | 0.0134164 |
| FAM193A | family with sequence similarity 193, member A | 0.0134154 |
| GABARAPL2 | GABA(A) receptor-associated protein-like 2 | 0.0133936 |
| MLEC | malectin | 0.0133471 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0133327 |
| ITGA6 | integrin, alpha 6 | 0.0133224 |
| EEA1 | early endosome antigen 1 | 0.0133124 |
| CREB1 | cAMP responsive element binding protein 1 | 0.0133031 |
| IPO11 | importin 11 | 0.0133011 |
| COPS8 | COP9 signalosome subunit 8 | 0.0132778 |
| RNF149 | ring finger protein 149 | 0.0132465 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0132461 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0132424 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.218487 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.165641 |
| COL11A1 | collagen, type XI, alpha 1 | -0.150007 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.134439 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.132052 |
| CADM2 | cell adhesion molecule 2 | -0.127118 |
| COL5A2 | collagen, type V, alpha 2 | -0.117416 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.1151 |
| TMSB10 | thymosin beta 10 | -0.112518 |
| AHNAK | AHNAK nucleoprotein | -0.109412 |
| UBC | ubiquitin C | -0.0983484 |
| THBS1 | thrombospondin 1 | -0.0977421 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0929116 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0920628 |
| COL3A1 | collagen, type III, alpha 1 | -0.0877621 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0877354 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0867889 |
| PHIP | pleckstrin homology domain interacting protein | -0.0861751 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0847282 |
| ACTG1 | actin gamma 1 | -0.0844774 |
| EMP1 | epithelial membrane protein 1 | -0.0836744 |
| ITGAV | integrin, alpha V | -0.083547 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0831552 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0809324 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0806627 |
| TENM3 | teneurin transmembrane protein 3 | -0.0766956 |
| GPC3 | glypican 3 | -0.0713315 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | -0.0694892 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | -0.0690137 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0685903 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0676039 |
| RPS27A | ribosomal protein S27a | -0.0665541 |
| CTNNA3 | catenin (cadherin-associated protein), alpha 3 | -0.0660386 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0656869 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0650307 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0628507 |
| DST | dystonin | -0.0628072 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0625883 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0612919 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0600985 |
| NHSL1 | NHS-like 1 | -0.0578219 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0566636 |
| HDAC9 | histone deacetylase 9 | -0.0564648 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0563789 |
| PLPP1 | phospholipid phosphatase 1 | -0.0552628 |
| APP | amyloid beta (A4) precursor protein | -0.0550512 |
| PCDH9 | protocadherin 9 | -0.054697 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0542758 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0540503 |
| ENO1 | enolase 1, (alpha) | -0.0539045 |
| TMSB4X | thymosin beta 4, X-linked | -0.053785 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | -0.0531742 |
| PCDH7 | protocadherin 7 | -0.0526449 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | -0.0525584 |
| NEBL | nebulette | -0.0522401 |
| POTEF | POTE ankyrin domain family, member F | -0.0506953 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0501895 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0498978 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0498582 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0485122 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0477556 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0467661 |
| STAG2 | stromal antigen 2 | -0.0467424 |
| UTRN | utrophin | -0.0463422 |
| CALU | calumenin | -0.0462241 |
| PGK1 | phosphoglycerate kinase 1 | -0.0459878 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0456648 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0455912 |
| S100A10 | S100 calcium binding protein A10 | -0.0445747 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0436399 |
| XPO1 | exportin 1 | -0.0427743 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0414653 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0414341 |
| ADGRL3 | adhesion G protein-coupled receptor L3 | -0.0413911 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0405499 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0405039 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0405038 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0402851 |
| BMPR1A | bone morphogenetic protein receptor, type IA | -0.0395899 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0390382 |
| VIM | vimentin | -0.039026 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0385884 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0383707 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | -0.0383261 |
| HS6ST2 | heparan sulfate 6-O-sulfotransferase 2 | -0.0382123 |
| ANK2 | ankyrin 2, neuronal | -0.0381685 |
| JUN | jun proto-oncogene | -0.0380205 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.0379138 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0375687 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0367555 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0367212 |
| TFRC | transferrin receptor | -0.0363666 |
| USP53 | ubiquitin specific peptidase 53 | -0.0359177 |
| NPAS3 | neuronal PAS domain protein 3 | -0.0358861 |
| RASAL2 | RAS protein activator like 2 | -0.0355304 |
| CKAP5 | cytoskeleton associated protein 5 | -0.0353206 |
| CDK12 | cyclin-dependent kinase 12 | -0.0352789 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0344604 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.034433 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0343741 |
