| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in PANC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0922189 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0664344 |
| VIM | vimentin | 0.0563629 |
| TMEM41B | transmembrane protein 41B | 0.0412799 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0325403 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0311381 |
| ANGPTL4 | angiopoietin-like 4 | 0.0299637 |
| VMP1 | vacuole membrane protein 1 | 0.0288163 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0279069 |
| S100A6 | S100 calcium binding protein A6 | 0.0250124 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0233443 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0228511 |
| KLF6 | Kruppel-like factor 6 | 0.0203165 |
| RPS7 | ribosomal protein S7 | 0.0201567 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0199474 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0198029 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 0.0192761 |
| RPS2 | ribosomal protein S2 | 0.017021 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0170079 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0167365 |
| MAP3K10 | mitogen-activated protein kinase kinase kinase 10 | 0.0155221 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.015228 |
| SERINC1 | serine incorporator 1 | 0.0143489 |
| HMGB2 | high mobility group box 2 | 0.0137826 |
| MFGE8 | milk fat globule-EGF factor 8 protein | 0.0134703 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0134176 |
| FDPS | farnesyl diphosphate synthase | 0.0129232 |
| RPS3 | ribosomal protein S3 | 0.0128492 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.012648 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0124292 |
| HYOU1 | hypoxia up-regulated 1 | 0.0124286 |
| MSMO1 | methylsterol monooxygenase 1 | 0.0122992 |
| SQLE | squalene epoxidase | 0.0121408 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0120284 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0118029 |
| CHMP5 | charged multivesicular body protein 5 | 0.0117829 |
| HLA-E | major histocompatibility complex, class I, E | 0.0117202 |
| FBXO32 | F-box protein 32 | 0.0115421 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0113846 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0112421 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0109827 |
| TXNDC12 | thioredoxin domain containing 12 (endoplasmic reticulum) | 0.0109344 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0107744 |
| UBE2J2 | ubiquitin-conjugating enzyme E2, J2 | 0.0107178 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.0106926 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.010688 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.0103621 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0102058 |
| FTL | ferritin, light polypeptide | 0.0101595 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.00990665 |
| RNASEH2A | ribonuclease H2, subunit A | 0.00976251 |
| EFCAB14 | EF-hand calcium binding domain 14 | 0.00976216 |
| MKRN1 | makorin ring finger protein 1 | 0.00973314 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.00960351 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.00950334 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 0.00948651 |
| DEPP1 | DEPP autophagy regulator 1 | 0.00945701 |
| URI1 | URI1, prefoldin-like chaperone | 0.00942465 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | 0.0094161 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00937997 |
| TXNRD1 | thioredoxin reductase 1 | 0.00931655 |
| BCL10 | B-cell CLL/lymphoma 10 | 0.00928288 |
| PHRF1 | PHD and ring finger domains 1 | 0.00926004 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0092549 |
| RPS12 | ribosomal protein S12 | 0.00910533 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.00889511 |
| KYAT3 | kynurenine aminotransferase 3 | 0.00882017 |
| IER2 | immediate early response 2 | 0.00872909 |
| ZC3H6 | zinc finger CCCH-type containing 6 | 0.00865718 |
| AMN1 | antagonist of mitotic exit network 1 homolog (S. cerevisiae) | 0.00864867 |
| PPP1R11 | protein phosphatase 1, regulatory (inhibitor) subunit 11 | 0.00863242 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.00857949 |
| MPHOSPH10 | M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) | 0.00850484 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | 0.00848952 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 0.00836115 |
| CAMLG | calcium modulating ligand | 0.00833777 |
| HELB | helicase (DNA) B | 0.00826575 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.00814968 |
| UBAP1 | ubiquitin associated protein 1 | 0.00813226 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.00802652 |
| LPIN1 | lipin 1 | 0.00801386 |
| FANCI | Fanconi anemia, complementation group I | 0.00798759 |
| ECH1 | enoyl CoA hydratase 1, peroxisomal | 0.00796902 |
| TBK1 | TANK-binding kinase 1 | 0.00796867 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | 0.00786834 |
| CEP152 | centrosomal protein 152kDa | 0.00784272 |
| CIB1 | calcium and integrin binding 1 (calmyrin) | 0.00774661 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.00772139 |
| ZNF608 | zinc finger protein 608 | 0.00771374 |
| ATP6V0E1 | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 | 0.00770451 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.00770317 |
| KPNA5 | karyopherin alpha 5 (importin alpha 6) | 0.00761795 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0075702 |
| MXI1 | MAX interactor 1, dimerization protein | 0.00753499 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.00753335 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.00751178 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.00748277 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.00746075 |
| SOAT2 | sterol O-acyltransferase 2 | 0.00745469 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.00743119 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.244949 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.223326 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.190894 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.161539 |
| AHNAK | AHNAK nucleoprotein | -0.151454 |
| FNDC3B | fibronectin type III domain containing 3B | -0.130999 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0979777 |
| DST | dystonin | -0.0963421 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0906187 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.087461 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0800846 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0792817 |
| PTK2 | protein tyrosine kinase 2 | -0.0755004 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0739342 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0718145 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0681754 |
| VCL | vinculin | -0.0669655 |
| FBL | fibrillarin | -0.065708 |
| NAV2 | neuron navigator 2 | -0.0652087 |
| ACTG1 | actin gamma 1 | -0.0649441 |
| FMNL2 | formin-like 2 | -0.0646503 |
| TNS3 | tensin 3 | -0.0627114 |
| MYOF | myoferlin | -0.0604682 |
| RPL35A | ribosomal protein L35a | -0.0596091 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.0587432 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0557757 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0555168 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0553709 |
| EGFR | epidermal growth factor receptor | -0.0517394 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0514066 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0509463 |
| ATXN1 | ataxin 1 | -0.0493456 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0492547 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | -0.0490193 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0486774 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0474572 |
| ASPH | aspartate beta-hydroxylase | -0.046735 |
| CD44 | CD44 molecule (Indian blood group) | -0.0460338 |
| SBF2 | SET binding factor 2 | -0.0451799 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0448253 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0446069 |
| HMGA2 | high mobility group AT-hook 2 | -0.0444739 |
| SAMD4B | sterile alpha motif domain containing 4B | -0.0442479 |
| UBC | ubiquitin C | -0.0440634 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0433091 |
| DIAPH2 | diaphanous-related formin 2 | -0.0426346 |
| RNF220 | ring finger protein 220 | -0.0426217 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0424931 |
| SEPTIN9 | septin 9 | -0.0421369 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0420836 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0420298 |
| TMSB10 | thymosin beta 10 | -0.0417617 |
| RPS16 | ribosomal protein S16 | -0.0415471 |
| CTBP2 | C-terminal binding protein 2 | -0.0415337 |
| ATG7 | autophagy related 7 | -0.0414051 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0411829 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0407335 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0405905 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0405529 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0404735 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0403047 |
| MED13L | mediator complex subunit 13-like | -0.0400609 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0400141 |
| NF1 | neurofibromin 1 | -0.0399448 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0396111 |
| TMEM123 | transmembrane protein 123 | -0.0395337 |
| PDE10A | phosphodiesterase 10A | -0.0393776 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0393593 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0385192 |
| MYO10 | myosin X | -0.0383966 |
| CANX | calnexin | -0.0383675 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0381316 |
| NHSL1 | NHS-like 1 | -0.0377635 |
| INTS6 | integrator complex subunit 6 | -0.0376657 |
| ZNF780B | zinc finger protein 780B | -0.0372549 |
| SMAD3 | SMAD family member 3 | -0.0368859 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0368337 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0366162 |
| LDHA | lactate dehydrogenase A | -0.0361189 |
| TAOK1 | TAO kinase 1 | -0.0357448 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0356926 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0353538 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0353188 |
| TCF12 | transcription factor 12 | -0.0351298 |
| ACTN4 | actinin, alpha 4 | -0.0348882 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0348468 |
| EFNA5 | ephrin-A5 | -0.0347896 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0345907 |
| RASAL2 | RAS protein activator like 2 | -0.0344631 |
| NUP98 | nucleoporin 98kDa | -0.0341494 |
| DEK | DEK proto-oncogene | -0.0332794 |
| RAD51B | RAD51 paralog B | -0.0331829 |
| QKI | QKI, KH domain containing, RNA binding | -0.0328992 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0327964 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0318562 |
| RPS24 | ribosomal protein S24 | -0.0318205 |
| PKM | pyruvate kinase, muscle | -0.0315298 |
| MAP1B | microtubule-associated protein 1B | -0.031446 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0313769 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0313071 |
