| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | 0.0851531 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0788979 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0599387 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0561894 |
| TMSB10 | thymosin beta 10 | 0.0561738 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0547591 |
| RPS3 | ribosomal protein S3 | 0.054043 |
| LAMB3 | laminin, beta 3 | 0.0487415 |
| MUC4 | mucin 4, cell surface associated | 0.0422553 |
| HMGB2 | high mobility group box 2 | 0.0417986 |
| S100A6 | S100 calcium binding protein A6 | 0.0416335 |
| KLF6 | Kruppel-like factor 6 | 0.0387628 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0369444 |
| MT2A | metallothionein 2A | 0.0367244 |
| RPL18 | ribosomal protein L18 | 0.0340144 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0338164 |
| RPS7 | ribosomal protein S7 | 0.030525 |
| WFDC2 | WAP four-disulfide core domain 2 | 0.0295266 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0291334 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.0282666 |
| RPL36 | ribosomal protein L36 | 0.025558 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0254466 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0250601 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.024595 |
| KRT17 | keratin 17, type I | 0.023735 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0224794 |
| DRAP1 | DR1-associated protein 1 (negative cofactor 2 alpha) | 0.0224037 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0220922 |
| RACK1 | receptor for activated C kinase 1 | 0.0215139 |
| VIM | vimentin | 0.021064 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0209886 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0209082 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0208029 |
| RPS12 | ribosomal protein S12 | 0.020699 |
| RPS27 | ribosomal protein S27 | 0.0206104 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0201303 |
| PLPP6 | phospholipid phosphatase 6 | 0.0196677 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0193956 |
| MTCH1 | mitochondrial carrier 1 | 0.0192106 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0191872 |
| CD9 | CD9 molecule | 0.0189474 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.018722 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0186547 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | 0.018627 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0181662 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0177379 |
| RPL12 | ribosomal protein L12 | 0.017716 |
| LSR | lipolysis stimulated lipoprotein receptor | 0.0175562 |
| GPX4 | glutathione peroxidase 4 | 0.0172271 |
| SNX6 | sorting nexin 6 | 0.0171874 |
| LIPH | lipase, member H | 0.0171718 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0171185 |
| C3 | complement component 3 | 0.0167312 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0165908 |
| FAM162A | family with sequence similarity 162, member A | 0.0162019 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0160975 |
| SERINC1 | serine incorporator 1 | 0.0160901 |
| RPL22L1 | ribosomal protein L22-like 1 | 0.0158784 |
| SEC62 | SEC62 homolog (S. cerevisiae) | 0.015835 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0157913 |
| ZBTB7A | zinc finger and BTB domain containing 7A | 0.0156935 |
| SRP54 | signal recognition particle 54kDa | 0.0156588 |
| SET | SET nuclear proto-oncogene | 0.0155206 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0154447 |
| ENO1 | enolase 1, (alpha) | 0.0153113 |
| COX6C | cytochrome c oxidase subunit VIc | 0.0152107 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0150768 |
| DAZAP1 | DAZ associated protein 1 | 0.0149516 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.014879 |
| CHMP5 | charged multivesicular body protein 5 | 0.0148298 |
| EGR1 | early growth response 1 | 0.0147995 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0147728 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0147435 |
| INHBA | inhibin, beta A | 0.0145062 |
| CAVIN1 | caveolae associated protein 1 | 0.0144424 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.014269 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.014126 |
| RAP2B | RAP2B, member of RAS oncogene family | 0.0139332 |
| ADGRE5 | adhesion G protein-coupled receptor E5 | 0.0138986 |
| PLAAT3 | phospholipase A and acyltransferase 3 | 0.0136959 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | 0.0135396 |
| CLIC1 | chloride intracellular channel 1 | 0.0133839 |
| TMF1 | TATA element modulatory factor 1 | 0.0133572 |
| RAI1 | retinoic acid induced 1 | 0.0132304 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0131386 |
| CBX3 | chromobox homolog 3 | 0.0131215 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0130766 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0130677 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0130005 |
| S100A11 | S100 calcium binding protein A11 | 0.0129457 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0127751 |
| GADD45GIP1 | growth arrest and DNA-damage-inducible, gamma interacting protein 1 | 0.0127692 |
| PSMD7 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 | 0.0127358 |
| PAIP1 | poly(A) binding protein interacting protein 1 | 0.0127212 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0126584 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.012645 |
| GOLGA2 | golgin A2 | 0.0126144 |
| FTL | ferritin, light polypeptide | 0.012511 |
| RPL36A | ribosomal protein L36a | 0.0124949 |
| PLAU | plasminogen activator, urokinase | 0.0124804 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.58504 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.118597 |
| ACTG1 | actin gamma 1 | -0.113938 |
| RPL35A | ribosomal protein L35a | -0.0964107 |
| AHNAK | AHNAK nucleoprotein | -0.0907858 |
| POTEF | POTE ankyrin domain family, member F | -0.0897088 |
| NDRG1 | N-myc downstream regulated 1 | -0.0854 |
| DSG2 | desmoglein 2 | -0.0796993 |
| RPS6 | ribosomal protein S6 | -0.0780628 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0705392 |
| CANX | calnexin | -0.0690074 |
| FAM3C | family with sequence similarity 3, member C | -0.0687616 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.064479 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0644175 |
| UBC | ubiquitin C | -0.0636412 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0608548 |
| KRT7 | keratin 7, type II | -0.0606115 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0595935 |
| RPS15 | ribosomal protein S15 | -0.0560022 |
| RBM39 | RNA binding motif protein 39 | -0.0551577 |
| HLA-B | major histocompatibility complex, class I, B | -0.0542453 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0536398 |
| RPS23 | ribosomal protein S23 | -0.0531639 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0524617 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0518177 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0499402 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.049654 |
| GOLGB1 | golgin B1 | -0.0469579 |
| NAV2 | neuron navigator 2 | -0.0465973 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0465614 |
| RPL8 | ribosomal protein L8 | -0.0460288 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0449572 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.042962 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0429368 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0421447 |
| G0S2 | G0/G1 switch 2 | -0.0414636 |
| KRT8 | keratin 8, type II | -0.0414421 |
| FLNB | filamin B, beta | -0.0401144 |
| TGM2 | transglutaminase 2 | -0.0394039 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0392269 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0391943 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0391926 |
| WWC1 | WW and C2 domain containing 1 | -0.0376462 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0373435 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0371384 |
| S100A10 | S100 calcium binding protein A10 | -0.036543 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0364381 |
| EMP1 | epithelial membrane protein 1 | -0.0357557 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.035689 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0355825 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0354154 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0353475 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.035172 |
| BRD4 | bromodomain containing 4 | -0.034969 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0346654 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0346319 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0341107 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0340559 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0339931 |
| RPS5 | ribosomal protein S5 | -0.0338146 |
| INTS6 | integrator complex subunit 6 | -0.0335028 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0334799 |
| ERBIN | erbb2 interacting protein | -0.033426 |
| DEK | DEK proto-oncogene | -0.0331199 |
| CD2AP | CD2-associated protein | -0.0331081 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.032922 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0327566 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0327207 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0326981 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.031752 |
| ADAR | adenosine deaminase, RNA-specific | -0.0317264 |
| TAPBP | TAP binding protein (tapasin) | -0.0316004 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0314216 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0314178 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0313888 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0312304 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | -0.0312097 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0310816 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0308776 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0306788 |
| PARD3 | par-3 family cell polarity regulator | -0.0306777 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0306722 |
| DSPP | dentin sialophosphoprotein | -0.0306206 |
| RASA2 | RAS p21 protein activator 2 | -0.0298507 |
| CASK | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | -0.0297103 |
| BBX | bobby sox homolog (Drosophila) | -0.0294886 |
| ARRDC3 | arrestin domain containing 3 | -0.029258 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0290384 |
| HLA-C | major histocompatibility complex, class I, C | -0.0288201 |
| RPS11 | ribosomal protein S11 | -0.0286212 |
| CDCP1 | CUB domain containing protein 1 | -0.0284944 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0284166 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0282549 |
| RPS10 | ribosomal protein S10 | -0.0281586 |
| SRSF3 | serine/arginine-rich splicing factor 3 | -0.0280147 |
| TAOK1 | TAO kinase 1 | -0.0278844 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.02785 |
| CD44 | CD44 molecule (Indian blood group) | -0.0273727 |
| DUSP5 | dual specificity phosphatase 5 | -0.0273242 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0273145 |
