Canagliflozin (hemihydrate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin (hemihydrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0792638
KMT2E lysine (K)-specific methyltransferase 2E 0.0686173
STC1 stanniocalcin 1 0.0664916
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0658421
NUP58 nucleoporin 58 0.0634078
SET SET nuclear proto-oncogene 0.0601321
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0601282
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0589322
WDR43 WD repeat domain 43 0.0554337
BHLHE40 basic helix-loop-helix family, member e40 0.0480965
CHD1 chromodomain helicase DNA binding protein 1 0.0480818
PDIA3 protein disulfide isomerase family A, member 3 0.0468173
WAC WW domain containing adaptor with coiled-coil 0.0429863
HMGB2 high mobility group box 2 0.0400532
PRRC2C proline-rich coiled-coil 2C 0.0395297
TOP1 topoisomerase (DNA) I 0.0394503
MAST4 microtubule associated serine/threonine kinase family member 4 0.0389694
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0384617
SRRM2 serine/arginine repetitive matrix 2 0.0380213
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0376912
SRRM1 serine/arginine repetitive matrix 1 0.0364315
CRY1 cryptochrome circadian clock 1 0.0361613
BRWD1 bromodomain and WD repeat domain containing 1 0.03458
ELL2 elongation factor, RNA polymerase II, 2 0.0344857
KDM6A lysine (K)-specific demethylase 6A 0.0344406
KMT2C lysine (K)-specific methyltransferase 2C 0.0343975
LAMB3 laminin, beta 3 0.0343938
PNISR PNN-interacting serine/arginine-rich protein 0.0342503
ZFP36L1 ZFP36 ring finger protein-like 1 0.0336532
RNF145 ring finger protein 145 0.0336056
UBA6 ubiquitin-like modifier activating enzyme 6 0.0334137
ATP13A3 ATPase type 13A3 0.0321613
FNDC3B fibronectin type III domain containing 3B 0.0317527
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0310092
GOLGA4 golgin A4 0.0307731
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.030492
RAB6A RAB6A, member RAS oncogene family 0.0302757
CSDE1 cold shock domain containing E1, RNA-binding 0.0302509
ZNF292 zinc finger protein 292 0.0301395
FHL2 four and a half LIM domains 2 0.0301063
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0297239
VMP1 vacuole membrane protein 1 0.0294283
RPS7 ribosomal protein S7 0.0293248
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0287154
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0286216
NCKAP1 NCK-associated protein 1 0.0285517
RLF rearranged L-myc fusion 0.0280952
KDM2A lysine (K)-specific demethylase 2A 0.0279887
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0279341
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0276817
SRSF11 serine/arginine-rich splicing factor 11 0.0276357
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0275757
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0274548
PUM1 pumilio RNA-binding family member 1 0.027145
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0269992
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0268733
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0267564
ZNF207 zinc finger protein 207 0.0264982
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0263723
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0261823
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0261574
GPBP1 GC-rich promoter binding protein 1 0.026038
OSBPL8 oxysterol binding protein-like 8 0.0256318
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0256102
CSNK1A1 casein kinase 1, alpha 1 0.0255948
GLS2 glutaminase 2 (liver, mitochondrial) 0.0255488
RNMT RNA (guanine-7-) methyltransferase 0.0254309
SETD5 SET domain containing 5 0.0253319
ZFC3H1 zinc finger, C3H1-type containing 0.0253257
SPAG9 sperm associated antigen 9 0.0251513
FMNL2 formin-like 2 0.0247088
RPS12 ribosomal protein S12 0.0245654
YTHDC1 YTH domain containing 1 0.0244837
RTN4 reticulon 4 0.0243403
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0241479
ZFAND3 zinc finger, AN1-type domain 3 0.0241316
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0240889
DAPK3 death-associated protein kinase 3 0.0238661
ACTN1 actinin, alpha 1 0.0238567
CALD1 caldesmon 1 0.0237751
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0236634
FOXO3 forkhead box O3 0.0236468
SBF2 SET binding factor 2 0.0236115
PIAS2 protein inhibitor of activated STAT, 2 0.0233823
NF1 neurofibromin 1 0.0233506
RPS3 ribosomal protein S3 0.0232494
RBM26 RNA binding motif protein 26 0.0232057
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0231268
RBM17 RNA binding motif protein 17 0.022943
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0228131
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0227283
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0227061
RBM25 RNA binding motif protein 25 0.0226451
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0225667
KIF5B kinesin family member 5B 0.022534
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0224606
SEC24A SEC24 family member A 0.0222007
XPO1 exportin 1 0.0221099
FRMD4A FERM domain containing 4A 0.0219923
MAP2K1 mitogen-activated protein kinase kinase 1 0.0219342

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.284649
ACTG1 actin gamma 1 -0.277899
RPL35A ribosomal protein L35a -0.140091
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.119689
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.106258
EXT1 exostosin glycosyltransferase 1 -0.102883
RPL8 ribosomal protein L8 -0.102494
RPS6 ribosomal protein S6 -0.0953201
RPLP1 ribosomal protein, large, P1 -0.0896699
FRMD6 FERM domain containing 6 -0.0811738
TPT1 tumor protein, translationally-controlled 1 -0.0801056
LOC112694756 uncharaterized LOC112694756 -0.078943
RPS21 ribosomal protein S21 -0.0742788
AHNAK AHNAK nucleoprotein -0.0725462
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0702191
ZNF438 zinc finger protein 438 -0.0699537
RPL34 ribosomal protein L34 -0.0683668
SLC38A2 solute carrier family 38, member 2 -0.0667308
RPL23 ribosomal protein L23 -0.0662314
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0653395
ARHGAP22 Rho GTPase activating protein 22 -0.0652953
RPS19 ribosomal protein S19 -0.0652515
EIF1 eukaryotic translation initiation factor 1 -0.0644795
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0634152
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0594154
TMSB10 thymosin beta 10 -0.0585855
NABP1 nucleic acid binding protein 1 -0.0574065
RPL7A ribosomal protein L7a -0.0571686
RPL32 ribosomal protein L32 -0.0569667
SAMD4A sterile alpha motif domain containing 4A -0.0561848
POTEF POTE ankyrin domain family, member F -0.054952
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0527664
RPS15 ribosomal protein S15 -0.0523433
RPS4X ribosomal protein S4, X-linked -0.0519199
RPLP2 ribosomal protein, large, P2 -0.0504581
RPL12 ribosomal protein L12 -0.0496169
RPS11 ribosomal protein S11 -0.0489337
EGR1 early growth response 1 -0.0485168
ASPH aspartate beta-hydroxylase -0.0463993
IFI16 interferon, gamma-inducible protein 16 -0.0457712
RPS29 ribosomal protein S29 -0.0445359
HMGA2 high mobility group AT-hook 2 -0.0444174
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0434293
TM4SF1 transmembrane 4 L six family member 1 -0.0432567
UBC ubiquitin C -0.042883
RPL19 ribosomal protein L19 -0.0427467
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0410753
RPL38 ribosomal protein L38 -0.0407347
RPL30 ribosomal protein L30 -0.0401873
MT2A metallothionein 2A -0.0397399
RRBP1 ribosome binding protein 1 -0.039502
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.038811
SP100 SP100 nuclear antigen -0.0382223
RAD51B RAD51 paralog B -0.037971
RPS23 ribosomal protein S23 -0.0377256
NAV3 neuron navigator 3 -0.0377109
NAV2 neuron navigator 2 -0.0375902
RPS24 ribosomal protein S24 -0.0374951
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0361312
RPL36 ribosomal protein L36 -0.0360753
RPS5 ribosomal protein S5 -0.0354663
TXNRD1 thioredoxin reductase 1 -0.0351155
PGK1 phosphoglycerate kinase 1 -0.0350703
HLA-C major histocompatibility complex, class I, C -0.0346721
CDK12 cyclin-dependent kinase 12 -0.0344979
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0337814
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0335975
DEK DEK proto-oncogene -0.0327069
RPL4 ribosomal protein L4 -0.0325757
RPL9 ribosomal protein L9 -0.0321572
DENND1A DENN/MADD domain containing 1A -0.0314262
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0309492
EXOC4 exocyst complex component 4 -0.0308551
DLC1 DLC1 Rho GTPase activating protein -0.0307539
RPLP0 ribosomal protein, large, P0 -0.030153
EMP1 epithelial membrane protein 1 -0.0294443
ZBTB20 zinc finger and BTB domain containing 20 -0.0293013
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0291434
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0289998
RPS20 ribosomal protein S20 -0.0288814
ALCAM activated leukocyte cell adhesion molecule -0.0281529
PARD3 par-3 family cell polarity regulator -0.02782
RPS8 ribosomal protein S8 -0.0276472
RPS16 ribosomal protein S16 -0.0274462
G0S2 G0/G1 switch 2 -0.0273946
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0273668
SETX senataxin -0.0271918
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0266413
S100A10 S100 calcium binding protein A10 -0.0263417
RPS13 ribosomal protein S13 -0.0260769
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0259247
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0258185
CD44 CD44 molecule (Indian blood group) -0.0256654
ANK2 ankyrin 2, neuronal -0.0256622
CCNI cyclin I -0.0256539
PTPRG protein tyrosine phosphatase, receptor type, G -0.0256078
RPS10 ribosomal protein S10 -0.0255549
TTR transthyretin -0.0255424
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0254719
FHIT fragile histidine triad -0.0253782