| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | 0.127849 |
| FN1 | fibronectin 1 | 0.120362 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0885893 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0860984 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0544974 |
| ZNF292 | zinc finger protein 292 | 0.0535423 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0530886 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.05038 |
| GOLGA4 | golgin A4 | 0.0452066 |
| PGK1 | phosphoglycerate kinase 1 | 0.0446075 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0421519 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0403905 |
| FAM13A | family with sequence similarity 13, member A | 0.0384406 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0371687 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0369347 |
| HMGB2 | high mobility group box 2 | 0.0358868 |
| LDHA | lactate dehydrogenase A | 0.0357748 |
| RLF | rearranged L-myc fusion | 0.0344685 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0340978 |
| CAVIN1 | caveolae associated protein 1 | 0.0340192 |
| COL1A2 | collagen, type I, alpha 2 | 0.0335858 |
| ATP13A3 | ATPase type 13A3 | 0.0335124 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0331366 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0330906 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0327533 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0325519 |
| CDC73 | cell division cycle 73 | 0.0324207 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0318289 |
| SRP54 | signal recognition particle 54kDa | 0.0316907 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0315504 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0305239 |
| COL6A2 | collagen, type VI, alpha 2 | 0.030503 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0298812 |
| NUP58 | nucleoporin 58 | 0.0297589 |
| CD109 | CD109 molecule | 0.0296708 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.028564 |
| SEC24A | SEC24 family member A | 0.0283673 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0280829 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0279855 |
| ANXA2 | annexin A2 | 0.0277778 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.027683 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.027673 |
| HELZ | helicase with zinc finger | 0.0275425 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0271433 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0270086 |
| MEF2A | myocyte enhancer factor 2A | 0.0263793 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0263582 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0262676 |
| XPO1 | exportin 1 | 0.0261537 |
| SEPTIN2 | septin 2 | 0.0261238 |
| TMEM39A | transmembrane protein 39A | 0.0261167 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0258516 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0256904 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0256487 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0253362 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0252953 |
| COPA | coatomer protein complex, subunit alpha | 0.025149 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0246516 |
| SEC24D | SEC24 family member D | 0.0245666 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0242863 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0241537 |
| OGA | O-GlcNAcase | 0.0241216 |
| USP37 | ubiquitin specific peptidase 37 | 0.0240106 |
| RTN4 | reticulon 4 | 0.0237544 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0235592 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.023546 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0235325 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0234255 |
| ANLN | anillin, actin binding protein | 0.0230885 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0230599 |
| FAM162A | family with sequence similarity 162, member A | 0.022932 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0227445 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0226879 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0226013 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0225328 |
| RBM39 | RNA binding motif protein 39 | 0.0224542 |
| QKI | QKI, KH domain containing, RNA binding | 0.0224328 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0222769 |
| NBAS | neuroblastoma amplified sequence | 0.0222383 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0221842 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0221683 |
| MYO1B | myosin IB | 0.0216598 |
| ENO1 | enolase 1, (alpha) | 0.021605 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0214309 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0213337 |
| PGM3 | phosphoglucomutase 3 | 0.0212486 |
| HYOU1 | hypoxia up-regulated 1 | 0.0211607 |
| SERINC1 | serine incorporator 1 | 0.0209765 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0206416 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0206224 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0206125 |
| CANX | calnexin | 0.0205742 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0205535 |
| RNF24 | ring finger protein 24 | 0.020486 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0204238 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0201604 |
| ABI1 | abl-interactor 1 | 0.0201319 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0201032 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | 0.0200431 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0198107 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.285027 |
| HLA-B | major histocompatibility complex, class I, B | -0.137636 |
| MT2A | metallothionein 2A | -0.122404 |
| TMSB10 | thymosin beta 10 | -0.0740523 |
| NDRG1 | N-myc downstream regulated 1 | -0.0733608 |
| RPL35A | ribosomal protein L35a | -0.0703667 |
| COL1A1 | collagen, type I, alpha 1 | -0.0691289 |
| CD44 | CD44 molecule (Indian blood group) | -0.0601817 |
| FTL | ferritin, light polypeptide | -0.0546613 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0502485 |
| B2M | beta-2-microglobulin | -0.0500948 |
| RPS19 | ribosomal protein S19 | -0.0490857 |
| POTEF | POTE ankyrin domain family, member F | -0.0478352 |
| RPLP1 | ribosomal protein, large, P1 | -0.0424046 |
| CDH13 | cadherin 13 | -0.0394105 |
| RPS6 | ribosomal protein S6 | -0.0386521 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0371972 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0364166 |
| HLA-A | major histocompatibility complex, class I, A | -0.0361409 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0358932 |
| RPS11 | ribosomal protein S11 | -0.0357634 |
| RPL28 | ribosomal protein L28 | -0.0352364 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0343059 |
| NAV1 | neuron navigator 1 | -0.0325176 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0323169 |
| RPS21 | ribosomal protein S21 | -0.0317931 |
| S100A10 | S100 calcium binding protein A10 | -0.031186 |
| ACTG1 | actin gamma 1 | -0.0306249 |
| RPL34 | ribosomal protein L34 | -0.0299781 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.029819 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0295368 |
| EGR1 | early growth response 1 | -0.0293939 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0289874 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0287477 |
| CST3 | cystatin C | -0.0285047 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0283462 |
| RPL31 | ribosomal protein L31 | -0.0281533 |
| RPLP2 | ribosomal protein, large, P2 | -0.0278152 |
| RPL23 | ribosomal protein L23 | -0.0278024 |
| SP100 | SP100 nuclear antigen | -0.0277235 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0274856 |
| FHIT | fragile histidine triad | -0.0273707 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0272795 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0272702 |
| RPS15 | ribosomal protein S15 | -0.0264972 |
| HLA-C | major histocompatibility complex, class I, C | -0.0262502 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0261743 |
| PKM | pyruvate kinase, muscle | -0.0259396 |
| UBC | ubiquitin C | -0.0259083 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0258105 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0256842 |
| RPS25 | ribosomal protein S25 | -0.025557 |
| IL1B | interleukin 1, beta | -0.0250291 |
| RPS8 | ribosomal protein S8 | -0.0247466 |
| NRP1 | neuropilin 1 | -0.0246939 |
| HDAC9 | histone deacetylase 9 | -0.0246444 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0245656 |
| CDCP1 | CUB domain containing protein 1 | -0.0243688 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0237252 |
| RPL11 | ribosomal protein L11 | -0.0235494 |
| FRMD4A | FERM domain containing 4A | -0.0235212 |
| KIAA1217 | KIAA1217 | -0.0232277 |
| RPS23 | ribosomal protein S23 | -0.0229735 |
| IER3 | immediate early response 3 | -0.0229391 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0229214 |
| RPL8 | ribosomal protein L8 | -0.0224952 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0220814 |
| FOSL1 | FOS-like antigen 1 | -0.0215154 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0213736 |
| OAZ1 | ornithine decarboxylase antizyme 1 | -0.0212395 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0211061 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.021101 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0209572 |
| RPL37A | ribosomal protein L37a | -0.0209067 |
| RPS13 | ribosomal protein S13 | -0.0208241 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0207511 |
| RPS29 | ribosomal protein S29 | -0.0207071 |
| IFI44L | interferon-induced protein 44-like | -0.0206443 |
| MT1X | metallothionein 1X | -0.0200174 |
| EXOC4 | exocyst complex component 4 | -0.0197986 |
| TAPBP | TAP binding protein (tapasin) | -0.0197717 |
| RPL9 | ribosomal protein L9 | -0.0197389 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0196915 |
| RPS10 | ribosomal protein S10 | -0.0196302 |
| DEK | DEK proto-oncogene | -0.0194811 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0194583 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0193618 |
| GLIS3 | GLIS family zinc finger 3 | -0.0191116 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0190549 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0189025 |
| SMAD3 | SMAD family member 3 | -0.0186531 |
| HMGA1 | high mobility group AT-hook 1 | -0.0186083 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0185958 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0185422 |
| SAMHD1 | SAM domain and HD domain 1 | -0.0181858 |
| PLSCR1 | phospholipid scramblase 1 | -0.0180788 |
| RPL30 | ribosomal protein L30 | -0.0180015 |
| RPS17 | ribosomal protein S17 | -0.017824 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0177992 |
| ADAM12 | ADAM metallopeptidase domain 12 | -0.0177699 |
