| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0596792 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0554322 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0407635 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0291789 |
| ZNF292 | zinc finger protein 292 | 0.0283252 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0267497 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0261029 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0253649 |
| SET | SET nuclear proto-oncogene | 0.0253544 |
| HMGB2 | high mobility group box 2 | 0.0246541 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0238386 |
| GAS2L3 | growth arrest-specific 2 like 3 | 0.0230683 |
| EGR1 | early growth response 1 | 0.0215652 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0212093 |
| MKI67 | marker of proliferation Ki-67 | 0.0211566 |
| VEGFA | vascular endothelial growth factor A | 0.0204717 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0191157 |
| MCL1 | myeloid cell leukemia 1 | 0.0189571 |
| PNN | pinin, desmosome associated protein | 0.0189558 |
| ENO1 | enolase 1, (alpha) | 0.0187652 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0185881 |
| CCNL1 | cyclin L1 | 0.0185327 |
| BCL6 | B-cell CLL/lymphoma 6 | 0.0184964 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0183773 |
| RPS7 | ribosomal protein S7 | 0.0183513 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0174973 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0170228 |
| TPM3 | tropomyosin 3 | 0.0167644 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0167489 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0166422 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0159324 |
| NIPSNAP2 | nipsnap homolog 2 | 0.0155955 |
| NCAM1 | neural cell adhesion molecule 1 | 0.0155185 |
| MSN | moesin | 0.0154822 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.0153034 |
| IRF2BPL | interferon regulatory factor 2 binding protein-like | 0.0152026 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0149666 |
| NUP58 | nucleoporin 58 | 0.0149566 |
| FKBP9 | FK506 binding protein 9, 63 kDa | 0.0148897 |
| CKAP2L | cytoskeleton associated protein 2-like | 0.0147612 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0147565 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0146228 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0145009 |
| HLTF | helicase-like transcription factor | 0.0142749 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0142385 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0141093 |
| DSTN | destrin (actin depolymerizing factor) | 0.0140177 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0136509 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0135924 |
| RYK | receptor-like tyrosine kinase | 0.0135402 |
| TSPYL2 | TSPY-like 2 | 0.0134866 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0132749 |
| RPL7 | ribosomal protein L7 | 0.0132525 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0132311 |
| ITGAV | integrin, alpha V | 0.0131761 |
| HYOU1 | hypoxia up-regulated 1 | 0.0131013 |
| RNPS1 | RNA binding protein S1, serine-rich domain | 0.0129709 |
| MATR3 | matrin 3 | 0.0129674 |
| YY1AP1 | YY1 associated protein 1 | 0.0129202 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0128002 |
| FAM13A | family with sequence similarity 13, member A | 0.0127655 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 0.012449 |
| AURKA | aurora kinase A | 0.0122067 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0122037 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0122012 |
| CENPF | centromere protein F, 350/400kDa | 0.0121838 |
| KIF11 | kinesin family member 11 | 0.0121514 |
| LMNB1 | lamin B1 | 0.0121247 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0120918 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0120648 |
| TPX2 | TPX2, microtubule-associated | 0.01204 |
| DHX32 | DEAH (Asp-Glu-Ala-His) box polypeptide 32 | 0.0119628 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0119324 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.011897 |
| FOCAD | focadhesin | 0.0118634 |
| XPO1 | exportin 1 | 0.01177 |
| RPL3 | ribosomal protein L3 | 0.0117602 |
| KIF23 | kinesin family member 23 | 0.0117305 |
| ATP5F1A | ATP synthase F1 subunit alpha | 0.011707 |
| WEE1 | WEE1 G2 checkpoint kinase | 0.0115294 |
| CSTF1 | cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa | 0.0115045 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0114856 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.0114788 |
| VMP1 | vacuole membrane protein 1 | 0.0114769 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0114095 |
| SNX6 | sorting nexin 6 | 0.0114052 |
| RPS12 | ribosomal protein S12 | 0.0113843 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.0113202 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.0110982 |
| AHR | aryl hydrocarbon receptor | 0.0110203 |
| AGMO | alkylglycerol monooxygenase | 0.0109838 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.010941 |
| HDAC9 | histone deacetylase 9 | 0.0109152 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0108264 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0107735 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0107366 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | 0.0106136 |
| CDK19 | cyclin-dependent kinase 19 | 0.0105925 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0105788 |
| SNAPC3 | small nuclear RNA activating complex, polypeptide 3, 50kDa | 0.0105356 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | -0.345451 |
| GPC6 | glypican 6 | -0.0860664 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0825595 |
| FGF14 | fibroblast growth factor 14 | -0.0781795 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0735409 |
| NRG1 | neuregulin 1 | -0.0732303 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0719118 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.0710589 |
| SMYD3 | SET and MYND domain containing 3 | -0.070958 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0688722 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0668175 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0644062 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0615398 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0613942 |
| NCKAP5 | NCK-associated protein 5 | -0.0589061 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0582199 |
| PTMA | prothymosin, alpha | -0.0575191 |
| ACTG1 | actin gamma 1 | -0.0559174 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | -0.0540698 |
| RIT2 | Ras-like without CAAX 2 | -0.0538948 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0536624 |
| SNAP25 | synaptosomal-associated protein, 25kDa | -0.051597 |
| VGF | VGF nerve growth factor inducible | -0.0501419 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0490216 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0490079 |
| CNKSR3 | CNKSR family member 3 | -0.0488982 |
| INHBA | inhibin, beta A | -0.0486992 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0478422 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0456969 |
| AOPEP | aminopeptidase O (putative) | -0.0450386 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0445573 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0439012 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0423376 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0422672 |
| NOVA1 | neuro-oncological ventral antigen 1 | -0.0420202 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | -0.0414504 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.040654 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0396426 |
| GDAP1 | ganglioside induced differentiation associated protein 1 | -0.0392898 |
| PGK1 | phosphoglycerate kinase 1 | -0.0391858 |
| PTCHD4 | patched domain containing 4 | -0.0391281 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0390411 |
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | -0.0386206 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0385058 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0376539 |
| NBEA | neurobeachin | -0.037015 |
| ST18 | suppression of tumorigenicity 18, zinc finger | -0.0365854 |
| CANX | calnexin | -0.0362137 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0361965 |
| SCG2 | secretogranin II | -0.0361579 |
| COL22A1 | collagen, type XXII, alpha 1 | -0.035784 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | -0.0355745 |
| TXNRD1 | thioredoxin reductase 1 | -0.0345748 |
| SIK2 | salt-inducible kinase 2 | -0.034084 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0337081 |
| H1-0 | H1.0 linker histone | -0.0335336 |
| RPL4 | ribosomal protein L4 | -0.0332286 |
| GPC5 | glypican 5 | -0.0330633 |
| CALCA | calcitonin-related polypeptide alpha | -0.0330346 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0327944 |
| SYT1 | synaptotagmin I | -0.032579 |
| NAV2 | neuron navigator 2 | -0.0324452 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0316704 |
| MAP7 | microtubule-associated protein 7 | -0.0316544 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | -0.0316323 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0312182 |
| TMSB4X | thymosin beta 4, X-linked | -0.0307665 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0304537 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0304258 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0301929 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | -0.0301274 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0297633 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0297614 |
| EFNA5 | ephrin-A5 | -0.0296711 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0295337 |
| RPL38 | ribosomal protein L38 | -0.0292763 |
| TENM1 | teneurin transmembrane protein 1 | -0.0292563 |
| AUTS2 | autism susceptibility candidate 2 | -0.0292186 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0286271 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.028484 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0282943 |
| PCSK2 | proprotein convertase subtilisin/kexin type 2 | -0.0280753 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0280721 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | -0.0278212 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0276647 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0276389 |
| RPS21 | ribosomal protein S21 | -0.0275796 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | -0.0272769 |
| TOX | thymocyte selection-associated high mobility group box | -0.0269937 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 | -0.0268345 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0267714 |
| FUS | FUS RNA binding protein | -0.026579 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0265287 |
| CORO1C | coronin, actin binding protein, 1C | -0.0262575 |
| JAZF1 | JAZF zinc finger 1 | -0.0261161 |
| RPL8 | ribosomal protein L8 | -0.026066 |
| TUBB | tubulin, beta class I | -0.0258669 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0258502 |
| FTL | ferritin, light polypeptide | -0.0257847 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0255834 |
