Canagliflozin (hemihydrate)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin (hemihydrate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.111283
LSAMP limbic system-associated membrane protein 0.0872408
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0855856
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.079565
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0735076
SREBF2 sterol regulatory element binding transcription factor 2 0.0734444
GOLGA4 golgin A4 0.0696316
FN1 fibronectin 1 0.0684522
CSDE1 cold shock domain containing E1, RNA-binding 0.0592136
KMT2E lysine (K)-specific methyltransferase 2E 0.0542158
SPAG9 sperm associated antigen 9 0.0535776
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0464982
NAMPT nicotinamide phosphoribosyltransferase 0.0461858
IL1RAP interleukin 1 receptor accessory protein 0.0461717
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0460567
CHD1 chromodomain helicase DNA binding protein 1 0.0446615
SEC24A SEC24 family member A 0.0437687
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0408805
CLINT1 clathrin interactor 1 0.0408106
ARHGAP5 Rho GTPase activating protein 5 0.0405095
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0397806
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.039505
CXCL8 chemokine (C-X-C motif) ligand 8 0.0390585
VMP1 vacuole membrane protein 1 0.0390373
ELL2 elongation factor, RNA polymerase II, 2 0.0378644
CANX calnexin 0.0375246
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0372131
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0367306
ABI1 abl-interactor 1 0.0362478
AKAP12 A kinase (PRKA) anchor protein 12 0.0352327
INPP5F inositol polyphosphate-5-phosphatase F 0.0350531
OGA O-GlcNAcase 0.033948
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0337645
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0336694
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0334189
CDK19 cyclin-dependent kinase 19 0.0333834
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0333702
COPA coatomer protein complex, subunit alpha 0.0332831
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0330264
BRWD3 bromodomain and WD repeat domain containing 3 0.0327498
WDR45B WD repeat domain 45B 0.0320702
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0318535
BACE2 beta-site APP-cleaving enzyme 2 0.0315368
FLNA filamin A, alpha 0.0314578
RPS3 ribosomal protein S3 0.0309172
NGLY1 N-glycanase 1 0.0305132
HMGB2 high mobility group box 2 0.0301147
BZW1 basic leucine zipper and W2 domains 1 0.0295096
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0294238
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0293935
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0292153
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0288411
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.02857
ATP13A3 ATPase type 13A3 0.0281752
SRP54 signal recognition particle 54kDa 0.0279278
BHLHE40 basic helix-loop-helix family, member e40 0.0278104
WAC WW domain containing adaptor with coiled-coil 0.0270095
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0270029
TMF1 TATA element modulatory factor 1 0.0267903
SLC39A11 solute carrier family 39, member 11 0.0257771
FMNL2 formin-like 2 0.0255146
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0254116
TRIQK triple QxxK/R motif containing 0.02502
RNF145 ring finger protein 145 0.0247577
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0247537
CREBRF CREB3 regulatory factor 0.0247214
FAM13A family with sequence similarity 13, member A 0.0246295
YEATS2 YEATS domain containing 2 0.0245825
ZNF292 zinc finger protein 292 0.0244517
FAM13B family with sequence similarity 13, member B 0.0243271
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0242956
AFDN afadin, adherens junction formation factor 0.0241834
RB1CC1 RB1-inducible coiled-coil 1 0.0241545
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0240438
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0238616
KPNB1 karyopherin (importin) beta 1 0.0237256
RAB7A RAB7A, member RAS oncogene family 0.0236507
UBA6 ubiquitin-like modifier activating enzyme 6 0.0236398
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0235264
JMJD1C jumonji domain containing 1C 0.0233179
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0232896
ZNF654 zinc finger protein 654 0.023167
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0227792
ASXL1 additional sex combs like transcriptional regulator 1 0.0227249
IQGAP1 IQ motif containing GTPase activating protein 1 0.0225622
STK4 serine/threonine kinase 4 0.0225436
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0220019
KAZN kazrin, periplakin interacting protein 0.0219548
EIF4H eukaryotic translation initiation factor 4H 0.0219352
KDM5B lysine (K)-specific demethylase 5B 0.0218516
NCKAP1 NCK-associated protein 1 0.0218143
PNPLA8 patatin-like phospholipase domain containing 8 0.0217261
MXI1 MAX interactor 1, dimerization protein 0.0216176
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0216122
STRN3 striatin, calmodulin binding protein 3 0.0214907
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0214171
KIF5B kinesin family member 5B 0.0214085
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0213461
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0213414
AFF4 AF4/FMR2 family, member 4 0.0213339

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.271728
NLGN1 neuroligin 1 -0.179692
CCND1 cyclin D1 -0.112081
TMSB10 thymosin beta 10 -0.107832
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.101003
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0986339
POTEF POTE ankyrin domain family, member F -0.0942441
MT2A metallothionein 2A -0.0915916
RPL35A ribosomal protein L35a -0.0900173
RPS6 ribosomal protein S6 -0.0704814
RPS23 ribosomal protein S23 -0.0602281
ACTG1 actin gamma 1 -0.0558375
PKM pyruvate kinase, muscle -0.0551374
APOD apolipoprotein D -0.0542752
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0523316
TM4SF1 transmembrane 4 L six family member 1 -0.0518717
HLA-B major histocompatibility complex, class I, B -0.0515477
IFI6 interferon, alpha-inducible protein 6 -0.0509452
RPLP1 ribosomal protein, large, P1 -0.0501792
S100A10 S100 calcium binding protein A10 -0.0475972
RPS19 ribosomal protein S19 -0.0447253
RPL38 ribosomal protein L38 -0.0437367
PDE4D phosphodiesterase 4D, cAMP-specific -0.0437006
B2M beta-2-microglobulin -0.0424661
ZBTB20 zinc finger and BTB domain containing 20 -0.0422795
RPLP2 ribosomal protein, large, P2 -0.0408018
PGK1 phosphoglycerate kinase 1 -0.039327
RPL34 ribosomal protein L34 -0.0382914
NRG3 neuregulin 3 -0.0376691
CENPF centromere protein F, 350/400kDa -0.036885
CD44 CD44 molecule (Indian blood group) -0.0361128
PTPRG protein tyrosine phosphatase, receptor type, G -0.0355954
RPL31 ribosomal protein L31 -0.035424
RPL23 ribosomal protein L23 -0.0345792
BPTF bromodomain PHD finger transcription factor -0.0344126
CDK6 cyclin-dependent kinase 6 -0.0339717
NDRG1 N-myc downstream regulated 1 -0.0339002
RPS11 ribosomal protein S11 -0.0337489
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0334447
RPL19 ribosomal protein L19 -0.0333515
IFIH1 interferon induced with helicase C domain 1 -0.0326703
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.032501
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0318152
TOB2 transducer of ERBB2, 2 -0.0317649
VDAC1 voltage-dependent anion channel 1 -0.0316943
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0316673
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0308412
S100A9 S100 calcium binding protein A9 -0.0307238
RPS8 ribosomal protein S8 -0.0306847
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0306094
RPS29 ribosomal protein S29 -0.0306069
SP100 SP100 nuclear antigen -0.0303641
FRMD4A FERM domain containing 4A -0.0301351
MARCKS myristoylated alanine-rich protein kinase C substrate -0.03003
RPS13 ribosomal protein S13 -0.0299746
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0291947
RNF213 ring finger protein 213 -0.0291846
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.029037
RPS15 ribosomal protein S15 -0.028896
RPS21 ribosomal protein S21 -0.0288667
WWTR1 WW domain containing transcription regulator 1 -0.0288012
DEK DEK proto-oncogene -0.0284332
IFITM3 interferon induced transmembrane protein 3 -0.0283035
RHOBTB3 Rho-related BTB domain containing 3 -0.028238
COMMD10 COMM domain containing 10 -0.0282138
IFI44L interferon-induced protein 44-like -0.0281894
RAD51B RAD51 paralog B -0.028097
RPS14 ribosomal protein S14 -0.0279343
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0278851
ATXN1 ataxin 1 -0.0277619
FOXP1 forkhead box P1 -0.0275054
HMGA1 high mobility group AT-hook 1 -0.0274826
RPS10 ribosomal protein S10 -0.0273667
RPS4X ribosomal protein S4, X-linked -0.0273422
RPL28 ribosomal protein L28 -0.0273419
NAV2 neuron navigator 2 -0.0269902
ACTN4 actinin, alpha 4 -0.0268571
CD63 CD63 molecule -0.0267527
RPL27 ribosomal protein L27 -0.0266343
ASTN2 astrotactin 2 -0.0264334
AUTS2 autism susceptibility candidate 2 -0.0264081
RUNX1 runt-related transcription factor 1 -0.0263589
RPS5 ribosomal protein S5 -0.0262841
TPI1 triosephosphate isomerase 1 -0.0260574
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0259299
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0259064
TXNRD1 thioredoxin reductase 1 -0.0258217
CTSD cathepsin D -0.0257436
EIF1 eukaryotic translation initiation factor 1 -0.025658
RPL32 ribosomal protein L32 -0.02551
EFNA5 ephrin-A5 -0.0253297
DPP6 dipeptidyl-peptidase 6 -0.0250433
IFI16 interferon, gamma-inducible protein 16 -0.0245629
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.024349
RIGI RNA sensor RIG-I -0.0243306
RPS20 ribosomal protein S20 -0.024308
WARS1 tryptophanyl-tRNA synthetase 1 -0.0242691
RPL9 ribosomal protein L9 -0.0242518
CYB5R3 cytochrome b5 reductase 3 -0.0241915
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0240474