| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.117486 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0940838 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0834722 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0809715 |
| S100A6 | S100 calcium binding protein A6 | 0.0808987 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.079743 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0784247 |
| TXNRD1 | thioredoxin reductase 1 | 0.0776914 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0752662 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0742298 |
| PYGB | phosphorylase, glycogen; brain | 0.0698691 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0680352 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0678421 |
| LDHA | lactate dehydrogenase A | 0.066007 |
| ANK2 | ankyrin 2, neuronal | 0.0649085 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0637085 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0611979 |
| TMSB4X | thymosin beta 4, X-linked | 0.0596429 |
| SMYD3 | SET and MYND domain containing 3 | 0.0582281 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0563211 |
| VCL | vinculin | 0.0561857 |
| HDAC9 | histone deacetylase 9 | 0.0544849 |
| EGFR | epidermal growth factor receptor | 0.0511883 |
| TXNIP | thioredoxin interacting protein | 0.050356 |
| RTN4 | reticulon 4 | 0.0487111 |
| VMP1 | vacuole membrane protein 1 | 0.0459687 |
| OSMR | oncostatin M receptor | 0.0453857 |
| SQSTM1 | sequestosome 1 | 0.0452121 |
| TRERF1 | transcriptional regulating factor 1 | 0.0436145 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0432093 |
| RPLP0 | ribosomal protein, large, P0 | 0.0429137 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0426163 |
| GOLGA4 | golgin A4 | 0.0424699 |
| EFNA5 | ephrin-A5 | 0.0410954 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | 0.0399421 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0396213 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0395097 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0377764 |
| APP | amyloid beta (A4) precursor protein | 0.0377019 |
| ENO1 | enolase 1, (alpha) | 0.0375501 |
| PHF14 | PHD finger protein 14 | 0.0374316 |
| B2M | beta-2-microglobulin | 0.0372051 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0371854 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0359497 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0345796 |
| RNF145 | ring finger protein 145 | 0.0340193 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0335442 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0330263 |
| RHBDD1 | rhomboid domain containing 1 | 0.0329809 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0325738 |
| GOLGA2 | golgin A2 | 0.0321494 |
| DOCK3 | dedicator of cytokinesis 3 | 0.0319943 |
| BPTF | bromodomain PHD finger transcription factor | 0.0314969 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0311796 |
| METTL15 | methyltransferase like 15 | 0.0310963 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0310556 |
| TNRC6B | trinucleotide repeat containing 6B | 0.0307248 |
| ENOSF1 | enolase superfamily member 1 | 0.0306298 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0305806 |
| OGA | O-GlcNAcase | 0.03047 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0304303 |
| SMNDC1 | survival motor neuron domain containing 1 | 0.0303156 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.030221 |
| RAD50 | RAD50 homolog (S. cerevisiae) | 0.0296983 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0296355 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.029614 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0295775 |
| YME1L1 | YME1-like 1 ATPase | 0.0295355 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0290765 |
| PRPF38B | pre-mRNA processing factor 38B | 0.0287762 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0286687 |
| FHAD1 | forkhead-associated (FHA) phosphopeptide binding domain 1 | 0.028141 |
| PTEN | phosphatase and tensin homolog | 0.0281013 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0280775 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.02806 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0278329 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0276812 |
| VGLL4 | vestigial-like family member 4 | 0.0276173 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0275348 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.027335 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | 0.0272859 |
| ITGAV | integrin, alpha V | 0.0272473 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0272329 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0271915 |
| TMEM41B | transmembrane protein 41B | 0.0271779 |
| PIWIL1 | piwi-like RNA-mediated gene silencing 1 | 0.0271206 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0270216 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0269366 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0267248 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0263597 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0262226 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0261799 |
| SFTPA2 | surfactant protein A2 | 0.0258778 |
| MAP3K8 | mitogen-activated protein kinase kinase kinase 8 | 0.0256734 |
| CUL5 | cullin 5 | 0.0255421 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0253223 |
| NBEAL1 | neurobeachin-like 1 | 0.0252743 |
| DARS1 | aspartyl-tRNA synthetase 1 | 0.0251964 |
| IL6ST | interleukin 6 signal transducer | 0.025119 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | 0.0251178 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.110093 |
| NAV2 | neuron navigator 2 | -0.102621 |
| DIAPH3 | diaphanous-related formin 3 | -0.080278 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0764076 |
| BMP10 | bone morphogenetic protein 10 | -0.0735633 |
| AHNAK | AHNAK nucleoprotein | -0.0730248 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0725615 |
| MKI67 | marker of proliferation Ki-67 | -0.064625 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0640982 |
| GLI2 | GLI family zinc finger 2 | -0.0593378 |
| SMC4 | structural maintenance of chromosomes 4 | -0.057541 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.05676 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0562997 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0553947 |
| ECT2 | epithelial cell transforming 2 | -0.0538706 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0501649 |
| CENPF | centromere protein F, 350/400kDa | -0.0498896 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0483115 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0476829 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.046482 |
| CENPE | centromere protein E, 312kDa | -0.0457902 |
| RAD18 | RAD18 E3 ubiquitin protein ligase | -0.0438327 |
| TPX2 | TPX2, microtubule-associated | -0.0426863 |
| CDK5RAP2 | CDK5 regulatory subunit associated protein 2 | -0.0405036 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | -0.0401386 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0395695 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.038982 |
| RPL36 | ribosomal protein L36 | -0.0375604 |
| RPS8 | ribosomal protein S8 | -0.0370584 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0364025 |
| ANLN | anillin, actin binding protein | -0.0355332 |
| GSE1 | Gse1 coiled-coil protein | -0.0337498 |
| INTS6 | integrator complex subunit 6 | -0.0333854 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0331039 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0330136 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0323861 |
| BMP2K | BMP2 inducible kinase | -0.0323234 |
| GLI3 | GLI family zinc finger 3 | -0.0322076 |
| RPL19 | ribosomal protein L19 | -0.0321894 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0315655 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0315402 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0310421 |
| HJURP | Holliday junction recognition protein | -0.0308307 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | -0.0305149 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.030364 |
| FER1L6 | fer-1-like family member 6 | -0.0303068 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0301471 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0301115 |
| AEBP2 | AE binding protein 2 | -0.0298488 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0297733 |
| EZR | ezrin | -0.0297085 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0291916 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0291148 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0290298 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0289288 |
| SGMS2 | sphingomyelin synthase 2 | -0.0285778 |
| PKP4 | plakophilin 4 | -0.0285717 |
| PDE7B | phosphodiesterase 7B | -0.0284909 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0281903 |
| RPLP2 | ribosomal protein, large, P2 | -0.0279051 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0276475 |
| RPL37A | ribosomal protein L37a | -0.0275452 |
| RRM2 | ribonucleotide reductase M2 | -0.0274565 |
| MYO5C | myosin VC | -0.0273065 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.0268682 |
| POTEF | POTE ankyrin domain family, member F | -0.0267752 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0264425 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0260923 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0257106 |
| BUB1B | BUB1 mitotic checkpoint serine/threonine kinase B | -0.0255796 |
| CCNY | cyclin Y | -0.0255417 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.0253854 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0253828 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0253653 |
| RCOR1 | REST corepressor 1 | -0.0252387 |
| DENND1A | DENN/MADD domain containing 1A | -0.0251096 |
| RPS13 | ribosomal protein S13 | -0.0248942 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0244684 |
| CREBBP | CREB binding protein | -0.0244285 |
| HELLS | helicase, lymphoid-specific | -0.0243631 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.0242181 |
| TMSB10 | thymosin beta 10 | -0.0238218 |
| RPS3 | ribosomal protein S3 | -0.023177 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.023072 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.022759 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0224307 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0222877 |
| HMGB1 | high mobility group box 1 | -0.0220158 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.021662 |
| SH3TC2 | SH3 domain and tetratricopeptide repeats 2 | -0.0214264 |
| CCDC138 | coiled-coil domain containing 138 | -0.0214158 |
| TUBA1B | tubulin, alpha 1b | -0.0210789 |
| CTBP2 | C-terminal binding protein 2 | -0.0208334 |
| MYOF | myoferlin | -0.0208121 |
| CEP128 | centrosomal protein 128kDa | -0.0207918 |
| SACK1D | scaffolding CK1 anchoring protein D | -0.0207574 |
| NPAS2 | neuronal PAS domain protein 2 | -0.020748 |
| SRSF6 | serine/arginine-rich splicing factor 6 | -0.0206682 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0206268 |
| H1-4 | H1.4 linker histone, cluster member | -0.0205321 |
