Canagliflozin (hemihydrate)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin (hemihydrate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.187929
COL6A3 collagen, type VI, alpha 3 0.161548
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.141863
VIM vimentin 0.134879
STC1 stanniocalcin 1 0.130204
FTH1 ferritin, heavy polypeptide 1 0.0981525
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.085481
TGFBI transforming growth factor, beta-induced, 68kDa 0.0738617
HLA-A major histocompatibility complex, class I, A 0.0702133
IGFBP7 insulin-like growth factor binding protein 7 0.0594844
PTN pleiotrophin 0.0561606
ERRFI1 ERBB receptor feedback inhibitor 1 0.053933
CXCL8 chemokine (C-X-C motif) ligand 8 0.0529108
MAP1B microtubule-associated protein 1B 0.0522594
B2M beta-2-microglobulin 0.0499238
PDIA3 protein disulfide isomerase family A, member 3 0.0472412
VMP1 vacuole membrane protein 1 0.0467599
NRXN3 neurexin 3 0.0466867
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0466031
ARRDC3 arrestin domain containing 3 0.0461859
LGALS1 lectin, galactoside-binding, soluble, 1 0.045943
NDRG1 N-myc downstream regulated 1 0.0453253
COG5 component of oligomeric golgi complex 5 0.0449209
COPB1 coatomer protein complex, subunit beta 1 0.0447086
TPM4 tropomyosin 4 0.0433868
SBF2 SET binding factor 2 0.0422708
MORF4L2 mortality factor 4 like 2 0.0419404
SRSF11 serine/arginine-rich splicing factor 11 0.0415664
TNPO3 transportin 3 0.0404854
GOLGA4 golgin A4 0.03847
CLIP2 CAP-GLY domain containing linker protein 2 0.0381671
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.038114
DDIT4 DNA-damage-inducible transcript 4 0.037726
PRSS23 protease, serine, 23 0.0375385
VCL vinculin 0.0374305
RPS8 ribosomal protein S8 0.0373416
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0370131
MYADM myeloid-associated differentiation marker 0.0369359
MTDH metadherin 0.0368035
CLEC1B C-type lectin domain family 1, member B 0.0363888
VEGFA vascular endothelial growth factor A 0.0360489
ANKIB1 ankyrin repeat and IBR domain containing 1 0.035953
UBA6 ubiquitin-like modifier activating enzyme 6 0.0356543
HMGB2 high mobility group box 2 0.0353582
CLINT1 clathrin interactor 1 0.0351173
LAMB1 laminin, beta 1 0.0350694
LOX lysyl oxidase 0.0350491
MACF1 microtubule-actin crosslinking factor 1 0.0347652
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.0340077
SMC3 structural maintenance of chromosomes 3 0.0338935
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0334759
YIPF5 Yip1 domain family, member 5 0.0334471
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0332394
MLPH melanophilin 0.0329797
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0325325
SRP54 signal recognition particle 54kDa 0.0323281
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0323068
SMC5 structural maintenance of chromosomes 5 0.0320768
PDAP1 PDGFA associated protein 1 0.0317487
RSRC1 arginine/serine-rich coiled-coil 1 0.0315242
PKM pyruvate kinase, muscle 0.0314875
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0313561
WDR43 WD repeat domain 43 0.0310296
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0309414
TMEM123 transmembrane protein 123 0.0305302
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0305241
FAM13B family with sequence similarity 13, member B 0.0303698
ARHGAP35 Rho GTPase activating protein 35 0.0301563
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0301038
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0300257
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0298244
KRIT1 KRIT1, ankyrin repeat containing 0.0296432
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0295848
ZNF146 zinc finger protein 146 0.0295691
TPX2 TPX2, microtubule-associated 0.0295114
CHD9 chromodomain helicase DNA binding protein 9 0.0293805
HIPK2 homeodomain interacting protein kinase 2 0.0291192
CD44 CD44 molecule (Indian blood group) 0.0288489
TMED5 transmembrane emp24 protein transport domain containing 5 0.0287903
GNAS GNAS complex locus 0.0283126
GPR107 G protein-coupled receptor 107 0.0282607
RARS1 arginyl-tRNA synthetase 1 0.0280988
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.028092
CSF1 colony stimulating factor 1 (macrophage) 0.0279987
PDIA6 protein disulfide isomerase family A, member 6 0.0279687
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0277987
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0273296
TM9SF4 transmembrane 9 superfamily protein member 4 0.0273144
FLOT1 flotillin 1 0.027309
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0270983
GOLGA2 golgin A2 0.026937
RINT1 RAD50 interactor 1 0.0269254
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0268983
TGFB1 transforming growth factor, beta 1 0.0268866
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0268825
RAB7A RAB7A, member RAS oncogene family 0.0266309
DPYSL2 dihydropyrimidinase-like 2 0.0265469
MKI67 marker of proliferation Ki-67 0.0264276
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.026316
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0262634

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.198113
UBC ubiquitin C -0.131937
IGFBP3 insulin-like growth factor binding protein 3 -0.12968
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123781
SOD2 superoxide dismutase 2, mitochondrial -0.0734997
GRB10 growth factor receptor-bound protein 10 -0.071373
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0622683
SDC4 syndecan 4 -0.0600836
FNDC3B fibronectin type III domain containing 3B -0.0595147
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0558521
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0534475
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0530269
COL1A1 collagen, type I, alpha 1 -0.0527325
WTAP Wilms tumor 1 associated protein -0.0523804
UBE2H ubiquitin-conjugating enzyme E2H -0.0522217
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0503225
AHNAK AHNAK nucleoprotein -0.0499807
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0484619
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0484218
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0476121
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0471033
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0462979
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.045567
SSBP2 single-stranded DNA binding protein 2 -0.0452763
TPT1 tumor protein, translationally-controlled 1 -0.0447351
COL1A2 collagen, type I, alpha 2 -0.0446254
AUTS2 autism susceptibility candidate 2 -0.0433918
QKI QKI, KH domain containing, RNA binding -0.0433352
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0425426
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0423979
ACVR1 activin A receptor, type I -0.042103
CALD1 caldesmon 1 -0.0414427
IFRD1 interferon-related developmental regulator 1 -0.0411508
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0403454
SPAG9 sperm associated antigen 9 -0.0398113
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0395746
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0387651
ANKRD11 ankyrin repeat domain 11 -0.037838
ZFAND3 zinc finger, AN1-type domain 3 -0.0377349
ZNF292 zinc finger protein 292 -0.0369105
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0367792
CTSB cathepsin B -0.0357593
SMYD3 SET and MYND domain containing 3 -0.0356879
GLIS3 GLIS family zinc finger 3 -0.0354673
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0353086
CAMTA1 calmodulin binding transcription activator 1 -0.0350874
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.034903
ELF2 E74-like factor 2 (ets domain transcription factor) -0.034636
GLS2 glutaminase 2 (liver, mitochondrial) -0.0344312
LCOR ligand dependent nuclear receptor corepressor -0.0343932
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0340435
SEC24D SEC24 family member D -0.0338691
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0338375
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0337387
RAB10 RAB10, member RAS oncogene family -0.0337072
ATP13A3 ATPase type 13A3 -0.0335647
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0332623
CUL4B cullin 4B -0.0331983
ATXN1 ataxin 1 -0.0331348
H3-3B H3.3 histone B -0.0329496
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0329173
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0328941
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0328263
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0323273
FLNB filamin B, beta -0.0322203
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0321148
WAC WW domain containing adaptor with coiled-coil -0.0316038
ANO6 anoctamin 6 -0.0310196
LRIF1 ligand dependent nuclear receptor interacting factor 1 -0.0308264
FAM13A family with sequence similarity 13, member A -0.0308188
RPL37A ribosomal protein L37a -0.0306073
NOP58 NOP58 ribonucleoprotein -0.0305614
EXOC4 exocyst complex component 4 -0.030527
TAS2R14 taste receptor, type 2, member 14 -0.0303589
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0302607
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0301637
TWSG1 twisted gastrulation BMP signaling modulator 1 -0.0298009
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0297826
PCDH7 protocadherin 7 -0.0297352
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase -0.0296256
PDIA5 protein disulfide isomerase family A, member 5 -0.0294299
MEF2A myocyte enhancer factor 2A -0.0290883
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0288737
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0288364
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0287166
ARL8B ADP-ribosylation factor-like 8B -0.0286674
STRN3 striatin, calmodulin binding protein 3 -0.0285036
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0283522
KDM5B lysine (K)-specific demethylase 5B -0.0282811
CDC73 cell division cycle 73 -0.0281063
SEPTIN7 septin 7 -0.0278724
SETD2 SET domain containing 2 -0.0276848
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0276351
RLIM ring finger protein, LIM domain interacting -0.0275703
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0271845
TOP1 topoisomerase (DNA) I -0.0271466
MYOF myoferlin -0.0270979
EXT1 exostosin glycosyltransferase 1 -0.0268382
ZNF609 zinc finger protein 609 -0.0267912
GANAB glucosidase, alpha; neutral AB -0.0266619