| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.104929 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0947152 |
| ZNF292 | zinc finger protein 292 | 0.0937812 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0923576 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0894359 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0832482 |
| VIM | vimentin | 0.0771325 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0722992 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.068516 |
| MKI67 | marker of proliferation Ki-67 | 0.0672471 |
| RPL36 | ribosomal protein L36 | 0.0638179 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0627995 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0615213 |
| SET | SET nuclear proto-oncogene | 0.0606429 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0603509 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.060033 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0583968 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0538625 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.0538294 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0524289 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.051608 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0515021 |
| RTN4 | reticulon 4 | 0.0511066 |
| RPS3 | ribosomal protein S3 | 0.0500895 |
| RPLP1 | ribosomal protein, large, P1 | 0.0482694 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0472046 |
| KIF5B | kinesin family member 5B | 0.0471732 |
| RPS12 | ribosomal protein S12 | 0.0469122 |
| HMGB2 | high mobility group box 2 | 0.046419 |
| RPL23 | ribosomal protein L23 | 0.0462571 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.045661 |
| RPL26 | ribosomal protein L26 | 0.0453941 |
| VMP1 | vacuole membrane protein 1 | 0.0432283 |
| YBX3 | Y box binding protein 3 | 0.0430256 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.042675 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0420183 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0412608 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.0405256 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0398435 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.039793 |
| B2M | beta-2-microglobulin | 0.0397638 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.039321 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0384285 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0383733 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | 0.0382467 |
| SMYD3 | SET and MYND domain containing 3 | 0.0381867 |
| PCM1 | pericentriolar material 1 | 0.037947 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.03725 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0362097 |
| RPL12 | ribosomal protein L12 | 0.0361832 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0361176 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0359925 |
| CENPF | centromere protein F, 350/400kDa | 0.0359761 |
| TPX2 | TPX2, microtubule-associated | 0.0359603 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0355109 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.035508 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0354766 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0347111 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0344262 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0343186 |
| RBM25 | RNA binding motif protein 25 | 0.0334947 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0334943 |
| XPO1 | exportin 1 | 0.0334208 |
| RPS25 | ribosomal protein S25 | 0.0333706 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0333585 |
| BPTF | bromodomain PHD finger transcription factor | 0.0327141 |
| TBK1 | TANK-binding kinase 1 | 0.0324242 |
| UBAC2 | UBA domain containing 2 | 0.0323789 |
| RPLP2 | ribosomal protein, large, P2 | 0.0323704 |
| CEP295 | centrosomal protein 295kDa | 0.0323551 |
| CENPE | centromere protein E, 312kDa | 0.0322979 |
| HJURP | Holliday junction recognition protein | 0.032282 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0321745 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0320948 |
| GOLGA2 | golgin A2 | 0.0318548 |
| ANLN | anillin, actin binding protein | 0.0315926 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0314542 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0314195 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0313278 |
| MSN | moesin | 0.031271 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0312332 |
| ZC3H13 | zinc finger CCCH-type containing 13 | 0.0312249 |
| AURKA | aurora kinase A | 0.031075 |
| NUCB2 | nucleobindin 2 | 0.0306549 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0303169 |
| NUP58 | nucleoporin 58 | 0.0296744 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0295006 |
| CUL3 | cullin 3 | 0.0294204 |
| PCBP2 | poly(rC) binding protein 2 | 0.029386 |
| KIF2A | kinesin heavy chain member 2A | 0.0291828 |
| KIAA1958 | KIAA1958 | 0.0290689 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0289134 |
| SMC6 | structural maintenance of chromosomes 6 | 0.028898 |
| RDX | radixin | 0.0285385 |
| BRD2 | bromodomain containing 2 | 0.0284859 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0283514 |
| ATXN2 | ataxin 2 | 0.0278704 |
| ATXN2L | ataxin 2-like | 0.0278353 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0277719 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0277553 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.162328 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.123529 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.110494 |
| AHNAK | AHNAK nucleoprotein | -0.107747 |
| TMSB10 | thymosin beta 10 | -0.0803007 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.066606 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0651031 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0639299 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0633179 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0608911 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.059921 |
| IGF2 | insulin-like growth factor 2 | -0.05759 |
| DERA | deoxyribose-phosphate aldolase (putative) | -0.0567691 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0536921 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0530694 |
| FLNB | filamin B, beta | -0.0490621 |
| DST | dystonin | -0.0472964 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0462131 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.046202 |
| NDRG1 | N-myc downstream regulated 1 | -0.0442273 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0440587 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0434643 |
| HMGA2 | high mobility group AT-hook 2 | -0.0426339 |
| NF1 | neurofibromin 1 | -0.0421625 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0418697 |
| ASPH | aspartate beta-hydroxylase | -0.0416867 |
| ATM | ATM serine/threonine kinase | -0.0414258 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.041379 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0413271 |
| DNER | delta/notch-like EGF repeat containing | -0.0411342 |
| FMN1 | formin 1 | -0.0409993 |
| PRR16 | proline rich 16 | -0.0389896 |
| GPC6 | glypican 6 | -0.0386358 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0376094 |
| TCF12 | transcription factor 12 | -0.0375977 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0365539 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0362379 |
| MYOF | myoferlin | -0.0359752 |
| RNF213 | ring finger protein 213 | -0.035818 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0355483 |
| CD44 | CD44 molecule (Indian blood group) | -0.035371 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0351081 |
| PRKCA | protein kinase C, alpha | -0.0349821 |
| SUMF1 | sulfatase modifying factor 1 | -0.0347376 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0344766 |
| DENND1A | DENN/MADD domain containing 1A | -0.0343887 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0342694 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0340359 |
| UTRN | utrophin | -0.0334553 |
| RIN2 | Ras and Rab interactor 2 | -0.0333305 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0331162 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0329546 |
| SMAD2 | SMAD family member 2 | -0.0328609 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.03279 |
| ATG7 | autophagy related 7 | -0.0327198 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.032605 |
| TTC19 | tetratricopeptide repeat domain 19 | -0.032567 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.032516 |
| PTK2 | protein tyrosine kinase 2 | -0.0323232 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0319614 |
| FMNL2 | formin-like 2 | -0.031743 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0303193 |
| GPATCH8 | G patch domain containing 8 | -0.0301933 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0300559 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.029777 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0291865 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.028604 |
| SNX9 | sorting nexin 9 | -0.0282684 |
| CANX | calnexin | -0.0281478 |
| RAD51B | RAD51 paralog B | -0.0281225 |
| DTNA | dystrobrevin, alpha | -0.0281007 |
| PCED1B | PC-esterase domain containing 1B | -0.0280777 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0280655 |
| PURA | purine-rich element binding protein A | -0.0279698 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | -0.0279443 |
| LAMB1 | laminin, beta 1 | -0.027582 |
| GOLGA3 | golgin A3 | -0.0275635 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0275599 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0274505 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0272495 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0272107 |
| RAI14 | retinoic acid induced 14 | -0.0271631 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0269642 |
| NCOA6 | nuclear receptor coactivator 6 | -0.026869 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0268508 |
| GPC5 | glypican 5 | -0.0262089 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0261136 |
| DOCK3 | dedicator of cytokinesis 3 | -0.026024 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0259306 |
| ANGPTL4 | angiopoietin-like 4 | -0.0258049 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0257967 |
| CUX1 | cut-like homeobox 1 | -0.0255578 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0255341 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0253382 |
| GOLGB1 | golgin B1 | -0.0252366 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0252322 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0252053 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0250825 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0248453 |
| NBEAL1 | neurobeachin-like 1 | -0.0247124 |
