| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.238768 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.196982 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.12485 |
| MT2A | metallothionein 2A | 0.0636908 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0610414 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0551411 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.054929 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.054425 |
| TPR | translocated promoter region, nuclear basket protein | 0.0541867 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0540966 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0506823 |
| TXNIP | thioredoxin interacting protein | 0.0503063 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0481938 |
| RPL26 | ribosomal protein L26 | 0.0473744 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0454884 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.044709 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0439472 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.043661 |
| AHR | aryl hydrocarbon receptor | 0.0404072 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0400686 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0392081 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0384527 |
| RACK1 | receptor for activated C kinase 1 | 0.0381168 |
| RPS12 | ribosomal protein S12 | 0.0373831 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0354791 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0352391 |
| RPL18 | ribosomal protein L18 | 0.0351456 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0351074 |
| SFXN1 | sideroflexin 1 | 0.0346723 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0341884 |
| SMOX | spermine oxidase | 0.033978 |
| TMEM87A | transmembrane protein 87A | 0.0333864 |
| YBX3 | Y box binding protein 3 | 0.0326652 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0323781 |
| NUP58 | nucleoporin 58 | 0.0323383 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0319907 |
| SRP54 | signal recognition particle 54kDa | 0.0315297 |
| CREBRF | CREB3 regulatory factor | 0.0313346 |
| RNF145 | ring finger protein 145 | 0.0298484 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0288445 |
| TXNRD1 | thioredoxin reductase 1 | 0.0281619 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.028136 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0281022 |
| OGA | O-GlcNAcase | 0.0276068 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0275428 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.027485 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0268902 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0268311 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0267836 |
| WDR45B | WD repeat domain 45B | 0.0264871 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.026466 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0264418 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0264308 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0261944 |
| SEC24A | SEC24 family member A | 0.025942 |
| RNF24 | ring finger protein 24 | 0.0259314 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0255526 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0255268 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0250889 |
| YME1L1 | YME1-like 1 ATPase | 0.0244455 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0243119 |
| FAM13A | family with sequence similarity 13, member A | 0.024294 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0241374 |
| KIF5B | kinesin family member 5B | 0.0240087 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.023668 |
| RLF | rearranged L-myc fusion | 0.0229979 |
| EMSY | EMSY transcriptional repressor, BRCA2 interacting | 0.0229933 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0228209 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0227867 |
| AFDN | afadin, adherens junction formation factor | 0.0225071 |
| SERINC1 | serine incorporator 1 | 0.0223703 |
| KSR1 | kinase suppressor of ras 1 | 0.0219862 |
| CLINT1 | clathrin interactor 1 | 0.0218315 |
| FBXO32 | F-box protein 32 | 0.0218069 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0217375 |
| SUPT5H | suppressor of Ty 5 homolog (S. cerevisiae) | 0.0217239 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0216594 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.0215177 |
| CDC27 | cell division cycle 27 | 0.0212437 |
| HYOU1 | hypoxia up-regulated 1 | 0.0212133 |
| CFB | complement factor B | 0.0211267 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0211024 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0207385 |
| CD109 | CD109 molecule | 0.0207138 |
| FNBP1 | formin binding protein 1 | 0.0205162 |
| HOMER2 | homer scaffolding protein 2 | 0.0204166 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0203334 |
| RBM25 | RNA binding motif protein 25 | 0.0202838 |
| ATP6V0E1 | ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 | 0.0200877 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0198815 |
| CDC73 | cell division cycle 73 | 0.0198549 |
| FTL | ferritin, light polypeptide | 0.019849 |
| ZNF292 | zinc finger protein 292 | 0.01977 |
| RPS3 | ribosomal protein S3 | 0.0196926 |
| ZC3H15 | zinc finger CCCH-type containing 15 | 0.0194686 |
| MORF4L2 | mortality factor 4 like 2 | 0.0194451 |
| ETNK1 | ethanolamine kinase 1 | 0.0194412 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0193348 |
| MLEC | malectin | 0.0193147 |
| RPL12 | ribosomal protein L12 | 0.0193001 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.375483 |
| NRG1 | neuregulin 1 | -0.132051 |
| NDRG1 | N-myc downstream regulated 1 | -0.0791271 |
| RPL35A | ribosomal protein L35a | -0.0781804 |
| ACTG1 | actin gamma 1 | -0.0777407 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0746618 |
| HMGA2 | high mobility group AT-hook 2 | -0.0665382 |
| HLA-B | major histocompatibility complex, class I, B | -0.0643092 |
| INTS6 | integrator complex subunit 6 | -0.0642268 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.058407 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0582551 |
| POTEF | POTE ankyrin domain family, member F | -0.0576414 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0576157 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0563608 |
| S100A10 | S100 calcium binding protein A10 | -0.0518667 |
| ASPH | aspartate beta-hydroxylase | -0.0505227 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0489032 |
| UBC | ubiquitin C | -0.0486925 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0460488 |
| FN1 | fibronectin 1 | -0.0456545 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0442897 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0441751 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.043282 |
| GPC6 | glypican 6 | -0.0418722 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0405561 |
| RPS11 | ribosomal protein S11 | -0.039444 |
| RPS23 | ribosomal protein S23 | -0.0380005 |
| SMAD3 | SMAD family member 3 | -0.0370926 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0365149 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.036339 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0345971 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0340347 |
| VCL | vinculin | -0.033351 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0330247 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0321568 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0320733 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0320613 |
| LRRC23 | leucine rich repeat containing 23 | -0.0318195 |
| CTSD | cathepsin D | -0.0316523 |
| AEBP2 | AE binding protein 2 | -0.031561 |
| FLNB | filamin B, beta | -0.0313017 |
| RPL38 | ribosomal protein L38 | -0.0312602 |
| PTK2 | protein tyrosine kinase 2 | -0.030972 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0303343 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | -0.0299963 |
| RPS15 | ribosomal protein S15 | -0.0296104 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0292602 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0286692 |
| AHNAK | AHNAK nucleoprotein | -0.0279971 |
| RPS6 | ribosomal protein S6 | -0.0279736 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0276715 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0276646 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0273045 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0272676 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0272164 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0270853 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0269187 |
| RPL34 | ribosomal protein L34 | -0.026836 |
| ATN1 | atrophin 1 | -0.0262872 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0260164 |
| MCL1 | myeloid cell leukemia 1 | -0.0259764 |
| RPS29 | ribosomal protein S29 | -0.0258924 |
| CADM1 | cell adhesion molecule 1 | -0.0257516 |
| CCDC138 | coiled-coil domain containing 138 | -0.0255949 |
| RUNX1 | runt-related transcription factor 1 | -0.0255605 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0255063 |
| SEPTIN9 | septin 9 | -0.0254849 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0254477 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0253399 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0252045 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0251325 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0250443 |
| FAT1 | FAT atypical cadherin 1 | -0.0248644 |
| SLC35F3 | solute carrier family 35, member F3 | -0.024775 |
| EGFR | epidermal growth factor receptor | -0.0245737 |
| TNS3 | tensin 3 | -0.0243599 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0240758 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0240459 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.023974 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0238676 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.02372 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0231409 |
| SFTPA2 | surfactant protein A2 | -0.0229162 |
| FHIT | fragile histidine triad | -0.0229106 |
| PALLD | palladin, cytoskeletal associated protein | -0.0229099 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0228531 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0227158 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0226522 |
| RPL8 | ribosomal protein L8 | -0.0226315 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.022538 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0223836 |
| NAV2 | neuron navigator 2 | -0.0223655 |
| MLPH | melanophilin | -0.0217145 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0216234 |
| DSG2 | desmoglein 2 | -0.021504 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0213825 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0213016 |
| ADAR | adenosine deaminase, RNA-specific | -0.0212402 |
| PRELID2 | PRELI domain containing 2 | -0.0212299 |
| FMNL2 | formin-like 2 | -0.0211095 |
