| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in SW1417 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin (hemihydrate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.109729 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.108216 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0983183 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.076725 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0675374 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.058647 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0567365 |
| PTMA | prothymosin, alpha | 0.0469163 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0449368 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0368563 |
| RPS12 | ribosomal protein S12 | 0.0362163 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0360941 |
| PKM | pyruvate kinase, muscle | 0.0351164 |
| SET | SET nuclear proto-oncogene | 0.0347746 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0329208 |
| VMP1 | vacuole membrane protein 1 | 0.0324236 |
| B2M | beta-2-microglobulin | 0.0321853 |
| CBX3 | chromobox homolog 3 | 0.0321038 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0320228 |
| TMF1 | TATA element modulatory factor 1 | 0.0311026 |
| MKRN1 | makorin ring finger protein 1 | 0.030367 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0284772 |
| HMGB2 | high mobility group box 2 | 0.0283686 |
| CD47 | CD47 molecule | 0.0279642 |
| S100A6 | S100 calcium binding protein A6 | 0.0273032 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0267529 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0265712 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0263943 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0262798 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0261688 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0260018 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0251434 |
| FOSL1 | FOS-like antigen 1 | 0.0251397 |
| RPS7 | ribosomal protein S7 | 0.0249975 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.024936 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0247676 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0247295 |
| FLNA | filamin A, alpha | 0.0241728 |
| CDK19 | cyclin-dependent kinase 19 | 0.0240266 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0239606 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0236681 |
| PRELID2 | PRELI domain containing 2 | 0.0235684 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0231969 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.022704 |
| RALB | v-ral simian leukemia viral oncogene homolog B | 0.0221847 |
| USP8 | ubiquitin specific peptidase 8 | 0.0218101 |
| CTSA | cathepsin A | 0.0214448 |
| IWS1 | IWS1 homolog (S. cerevisiae) | 0.0213909 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0212381 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0212161 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0207769 |
| RAD51B | RAD51 paralog B | 0.0207418 |
| PCBP2 | poly(rC) binding protein 2 | 0.0205913 |
| SBDS | Shwachman-Bodian-Diamond syndrome | 0.0205426 |
| HYOU1 | hypoxia up-regulated 1 | 0.0204481 |
| CD9 | CD9 molecule | 0.0202941 |
| YEATS2 | YEATS domain containing 2 | 0.0202753 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0202213 |
| TMEM14B | transmembrane protein 14B | 0.0201614 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0200991 |
| TPM3 | tropomyosin 3 | 0.019722 |
| LMTK2 | lemur tyrosine kinase 2 | 0.0195811 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0194962 |
| DNM2 | dynamin 2 | 0.0194756 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0194248 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0192453 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0192204 |
| PAIP1 | poly(A) binding protein interacting protein 1 | 0.01914 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0188322 |
| CLDN3 | claudin 3 | 0.0187274 |
| CXXC5 | CXXC finger protein 5 | 0.0187139 |
| ENO1 | enolase 1, (alpha) | 0.0183309 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0182705 |
| TPM4 | tropomyosin 4 | 0.0181199 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0178299 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0176778 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0176703 |
| CNNM4 | cyclin and CBS domain divalent metal cation transport mediator 4 | 0.0175777 |
| TMEM87A | transmembrane protein 87A | 0.0174939 |
| DSPP | dentin sialophosphoprotein | 0.0174067 |
| MORF4L2 | mortality factor 4 like 2 | 0.0173584 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.017301 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.017217 |
| ITSN2 | intersectin 2 | 0.0171806 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0168826 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.016851 |
| CHMP5 | charged multivesicular body protein 5 | 0.0162632 |
| CAND1 | cullin-associated and neddylation-dissociated 1 | 0.0160819 |
| HLA-E | major histocompatibility complex, class I, E | 0.0160353 |
| MLEC | malectin | 0.0160007 |
| KIF5B | kinesin family member 5B | 0.0158091 |
| HDGF | hepatoma-derived growth factor | 0.0157687 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0156528 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0154799 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0154371 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0153722 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0152134 |
| GRIPAP1 | GRIP1 associated protein 1 | 0.0151949 |
| FOSL2 | FOS-like antigen 2 | 0.0151721 |
| TMEM167A | transmembrane protein 167A | 0.0149742 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.1305 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.114735 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.113766 |
| AHNAK | AHNAK nucleoprotein | -0.101 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0881302 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0806412 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.079079 |
| H1-0 | H1.0 linker histone | -0.0780625 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0776072 |
| RBM39 | RNA binding motif protein 39 | -0.0735995 |
| LOC112694756 | uncharaterized LOC112694756 | -0.071257 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0711871 |
| BCL2L1 | BCL2-like 1 | -0.0709157 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0686552 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | -0.0658641 |
| ACTN4 | actinin, alpha 4 | -0.0648388 |
| SNX9 | sorting nexin 9 | -0.0586364 |
| TMSB10 | thymosin beta 10 | -0.0549329 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.054339 |
| CANX | calnexin | -0.0530601 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0529606 |
| NEBL | nebulette | -0.0516281 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0513101 |
| UBC | ubiquitin C | -0.0507674 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0495303 |
| IER3 | immediate early response 3 | -0.0494604 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0491266 |
| RHEB | Ras homolog enriched in brain | -0.0489697 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0485813 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0482729 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0480572 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0472193 |
| KRT8 | keratin 8, type II | -0.0467522 |
| ACTG1 | actin gamma 1 | -0.046494 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0464884 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0464137 |
| PUM2 | pumilio RNA-binding family member 2 | -0.045257 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.045097 |
| RPL35A | ribosomal protein L35a | -0.0446732 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0445712 |
| CD2AP | CD2-associated protein | -0.0445419 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0445064 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0442324 |
| FBXO11 | F-box protein 11 | -0.0439594 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0437438 |
| GNAS | GNAS complex locus | -0.0437098 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0437064 |
| TGFA | transforming growth factor, alpha | -0.0432075 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0430761 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0430745 |
| TOP1 | topoisomerase (DNA) I | -0.0430333 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0427909 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0427439 |
| FAM3C | family with sequence similarity 3, member C | -0.0424637 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0423773 |
| SDC4 | syndecan 4 | -0.0419201 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0416362 |
| PLSCR1 | phospholipid scramblase 1 | -0.0414164 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.0411521 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0402417 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.03992 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0396716 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0395457 |
| CDK13 | cyclin-dependent kinase 13 | -0.0394691 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0392299 |
| LARP4B | La ribonucleoprotein domain family, member 4B | -0.0390173 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0383664 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0379894 |
| CTBP2 | C-terminal binding protein 2 | -0.0376685 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0375861 |
| VCL | vinculin | -0.0375136 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0369957 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0367661 |
| SMAD2 | SMAD family member 2 | -0.0356876 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0355638 |
| LMO7 | LIM domain 7 | -0.035447 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0353368 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0352541 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0348589 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0341859 |
| HM13 | histocompatibility (minor) 13 | -0.0341293 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0340442 |
| SPAG9 | sperm associated antigen 9 | -0.0340421 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0334195 |
| LAMA4 | laminin, alpha 4 | -0.0329659 |
| RASA2 | RAS p21 protein activator 2 | -0.0325166 |
| CARS1 | cysteinyl-tRNA synthetase 1 | -0.0324416 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0323883 |
| RPL32 | ribosomal protein L32 | -0.0322439 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0320927 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0319598 |
| GOLGB1 | golgin B1 | -0.0316115 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0314406 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0313934 |
| TJP1 | tight junction protein 1 | -0.0313767 |
| USP3 | ubiquitin specific peptidase 3 | -0.0309838 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0306459 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0306085 |
| NUP214 | nucleoporin 214kDa | -0.0305951 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0304407 |
