Canagliflozin (hemihydrate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin (hemihydrate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) 0.151962
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.104717
AREG amphiregulin 0.0932758
LMO7 LIM domain 7 0.0916818
PDE4B phosphodiesterase 4B, cAMP-specific 0.0862556
ANXA1 annexin A1 0.0855628
OXR1 oxidation resistance 1 0.0743632
TOP1 topoisomerase (DNA) I 0.0607234
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0597602
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0588618
PLAUR plasminogen activator, urokinase receptor 0.0587728
ITPRID2 ITPR interacting domain containing 2 0.0562749
RNF43 ring finger protein 43 0.0539246
GOLGA4 golgin A4 0.053885
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0535672
EREG epiregulin 0.0520323
EZR ezrin 0.0487146
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0459379
FAT1 FAT atypical cadherin 1 0.0453186
LAMC2 laminin, gamma 2 0.0434059
TXNRD1 thioredoxin reductase 1 0.0408436
KMT2C lysine (K)-specific methyltransferase 2C 0.0403452
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0402673
WAC WW domain containing adaptor with coiled-coil 0.0391459
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.038651
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0382682
BIRC3 baculoviral IAP repeat containing 3 0.0375716
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0371348
KDM6A lysine (K)-specific demethylase 6A 0.0360996
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.0347104
SLTM SAFB-like, transcription modulator 0.0338825
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0336201
RUNX2 runt-related transcription factor 2 0.0330481
HMGB2 high mobility group box 2 0.0325142
NCEH1 neutral cholesterol ester hydrolase 1 0.032346
STRN3 striatin, calmodulin binding protein 3 0.0322646
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.031958
RLF rearranged L-myc fusion 0.0317885
ZNF292 zinc finger protein 292 0.031141
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0306721
SLMAP sarcolemma associated protein 0.0305998
FERMT1 fermitin family member 1 0.0305648
OGA O-GlcNAcase 0.0292684
PTBP2 polypyrimidine tract binding protein 2 0.02915
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0285879
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0284517
CSDE1 cold shock domain containing E1, RNA-binding 0.0280749
PUM2 pumilio RNA-binding family member 2 0.0280169
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0278922
CLTC clathrin, heavy chain (Hc) 0.0277711
RBM25 RNA binding motif protein 25 0.0276603
DSCAM Down syndrome cell adhesion molecule 0.0276575
EVA1C eva-1 homolog C (C. elegans) 0.0276552
PRRC2C proline-rich coiled-coil 2C 0.0275607
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0273218
USP6NL USP6 N-terminal like 0.0272668
ZMYM2 zinc finger, MYM-type 2 0.0271153
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0271094
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0270537
NUP58 nucleoporin 58 0.0270119
EEF2 eukaryotic translation elongation factor 2 0.0269976
ESYT2 extended synaptotagmin-like protein 2 0.026551
MATR3 matrin 3 0.0263914
AXIN2 axin 2 0.0263486
NPEPPS aminopeptidase puromycin sensitive 0.0263387
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0256217
NAP1L1 nucleosome assembly protein 1-like 1 0.025498
LDHA lactate dehydrogenase A 0.025468
RBM39 RNA binding motif protein 39 0.0250799
KDM3A lysine (K)-specific demethylase 3A 0.0245279
UBA6 ubiquitin-like modifier activating enzyme 6 0.024187
ZNRF3 zinc and ring finger 3 0.024169
RNF145 ring finger protein 145 0.0240957
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0237444
MBNL1 muscleblind-like splicing regulator 1 0.023664
TPR translocated promoter region, nuclear basket protein 0.0235628
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 0.0235103
RAD21 RAD21 homolog (S. pombe) 0.0234774
ECT2 epithelial cell transforming 2 0.0231226
ARL5B ADP-ribosylation factor-like 5B 0.0231188
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0227761
PCNX1 pecanex 1 0.0226343
GARS1 glycyl-tRNA synthetase 1 0.0220426
MKI67 marker of proliferation Ki-67 0.0219373
KTN1 kinectin 1 (kinesin receptor) 0.0217203
FAR1 fatty acyl CoA reductase 1 0.0217203
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.021689
PDLIM5 PDZ and LIM domain 5 0.0215433
CEP152 centrosomal protein 152kDa 0.021504
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0214523
TXNIP thioredoxin interacting protein 0.0213939
MXI1 MAX interactor 1, dimerization protein 0.0213021
ABI1 abl-interactor 1 0.0210667
CHD1 chromodomain helicase DNA binding protein 1 0.0210026
BBX bobby sox homolog (Drosophila) 0.0209657
KITLG KIT ligand 0.0209475
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0209267
SFXN1 sideroflexin 1 0.0209018
WDR43 WD repeat domain 43 0.0208521
NCKAP1 NCK-associated protein 1 0.0206885

decreased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 -0.172337
RPL35A ribosomal protein L35a -0.100952
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0870698
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0840451
EGR1 early growth response 1 -0.0839116
RPS6 ribosomal protein S6 -0.0752755
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.069488
RCOR1 REST corepressor 1 -0.0676186
HMGA2 high mobility group AT-hook 2 -0.0670652
FHIT fragile histidine triad -0.0629475
TMSB10 thymosin beta 10 -0.0517488
IGFBP3 insulin-like growth factor binding protein 3 -0.0478861
CCSER1 coiled-coil serine-rich protein 1 -0.0464857
PTMA prothymosin, alpha -0.046124
RPS8 ribosomal protein S8 -0.0455322
RPL37A ribosomal protein L37a -0.0419011
GPC5 glypican 5 -0.0415838
RPS29 ribosomal protein S29 -0.0403344
RPL34 ribosomal protein L34 -0.0399719
CUX1 cut-like homeobox 1 -0.0397074
RPS23 ribosomal protein S23 -0.0391661
MPRIP myosin phosphatase Rho interacting protein -0.03909
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0389452
LAMA4 laminin, alpha 4 -0.0385108
RPL9 ribosomal protein L9 -0.0380872
TPT1 tumor protein, translationally-controlled 1 -0.0379208
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0357936
VCL vinculin -0.0354728
POTEF POTE ankyrin domain family, member F -0.0346659
RPL31 ribosomal protein L31 -0.0345611
RPS13 ribosomal protein S13 -0.0335309
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0330951
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0325273
RAD51B RAD51 paralog B -0.0310674
FLOT1 flotillin 1 -0.0308235
CMIP c-Maf inducing protein -0.0301119
RPS25 ribosomal protein S25 -0.0292835
RPS10 ribosomal protein S10 -0.0288124
CREB5 cAMP responsive element binding protein 5 -0.0277685
HLA-A major histocompatibility complex, class I, A -0.0275624
RPS19 ribosomal protein S19 -0.0271066
TRAF3 TNF receptor-associated factor 3 -0.0267024
HLA-B major histocompatibility complex, class I, B -0.0264934
DOCK5 dedicator of cytokinesis 5 -0.0262803
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0253883
RPLP1 ribosomal protein, large, P1 -0.0249967
GATAD2A GATA zinc finger domain containing 2A -0.0246379
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0245127
RPS17 ribosomal protein S17 -0.0244191
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0242971
FTL ferritin, light polypeptide -0.0241414
UBC ubiquitin C -0.024036
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0239863
RPL19 ribosomal protein L19 -0.0239425
RPL5 ribosomal protein L5 -0.0238706
RPS14 ribosomal protein S14 -0.0237841
ITGB4 integrin, beta 4 -0.0234083
RPLP2 ribosomal protein, large, P2 -0.0232072
ANKRD17 ankyrin repeat domain 17 -0.0229435
AKAP13 A kinase (PRKA) anchor protein 13 -0.0226645
ZCCHC7 zinc finger, CCHC domain containing 7 -0.022121
CCND1 cyclin D1 -0.021945
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0218994
RPS11 ribosomal protein S11 -0.0218656
EXOC4 exocyst complex component 4 -0.0214566
ATP5F1B ATP synthase F1 subunit beta -0.0213807
RPS27A ribosomal protein S27a -0.0210214
IARS1 isoleucyl-tRNA synthetase 1 -0.0209538
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0207869
UBAP2 ubiquitin associated protein 2 -0.0207797
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0207691
IER3 immediate early response 3 -0.0205752
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.020288
SGMS2 sphingomyelin synthase 2 -0.0202505
NUP50 nucleoporin 50kDa -0.0200888
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.019986
TENM3 teneurin transmembrane protein 3 -0.0199628
EFNB2 ephrin-B2 -0.0197318
ENO2 enolase 2 (gamma, neuronal) -0.0195462
ANKRD11 ankyrin repeat domain 11 -0.019351
JARID2 jumonji, AT rich interactive domain 2 -0.0193018
XYLT1 xylosyltransferase I -0.0192909
RPS21 ribosomal protein S21 -0.0190944
ABR active BCR-related -0.0189074
ACTN4 actinin, alpha 4 -0.0189036
RPS12 ribosomal protein S12 -0.0186584
RASAL2 RAS protein activator like 2 -0.0184152
HM13 histocompatibility (minor) 13 -0.0183842
RPL38 ribosomal protein L38 -0.0179682
SEPTIN9 septin 9 -0.0178191
KANK1 KN motif and ankyrin repeat domains 1 -0.0177931
VIM vimentin -0.0177855
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.017599
BPTF bromodomain PHD finger transcription factor -0.0175478
RPL37 ribosomal protein L37 -0.0174898
COMMD10 COMM domain containing 10 -0.0172422
SETD5 SET domain containing 5 -0.0172149
PCNX4 pecanex 4 -0.0171879
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0171741
RPL8 ribosomal protein L8 -0.0171699