| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin (hemihydrate) perturbation in SW480 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin (hemihydrate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0974863 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.085034 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.079973 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0619729 |
| ITGA6 | integrin, alpha 6 | 0.0612884 |
| GOLGA4 | golgin A4 | 0.0558364 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0536461 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0503553 |
| MORF4L2 | mortality factor 4 like 2 | 0.0487922 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0484014 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0439144 |
| ENO1 | enolase 1, (alpha) | 0.0436898 |
| VMP1 | vacuole membrane protein 1 | 0.0436707 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0433553 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0415998 |
| RPS3 | ribosomal protein S3 | 0.0413313 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0394233 |
| RPS7 | ribosomal protein S7 | 0.0382478 |
| TMF1 | TATA element modulatory factor 1 | 0.0375521 |
| NUP58 | nucleoporin 58 | 0.0355779 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0347813 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0347752 |
| PCBP2 | poly(rC) binding protein 2 | 0.0343491 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0335232 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0333851 |
| SET | SET nuclear proto-oncogene | 0.0327358 |
| HMGB2 | high mobility group box 2 | 0.0326232 |
| SRP54 | signal recognition particle 54kDa | 0.0316443 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0309229 |
| RPS12 | ribosomal protein S12 | 0.0305496 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0290934 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0288248 |
| MSN | moesin | 0.028768 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.028541 |
| ETNK1 | ethanolamine kinase 1 | 0.0284519 |
| AFDN | afadin, adherens junction formation factor | 0.0284358 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0282407 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0281906 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0281 |
| COPA | coatomer protein complex, subunit alpha | 0.0279237 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0270869 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0268612 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0264619 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0262163 |
| USP34 | ubiquitin specific peptidase 34 | 0.0258924 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0258731 |
| TMEM41B | transmembrane protein 41B | 0.0257728 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0257465 |
| ABHD2 | abhydrolase domain containing 2 | 0.0253325 |
| PNN | pinin, desmosome associated protein | 0.0250087 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0247175 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0243985 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0243181 |
| SEPTIN2 | septin 2 | 0.0239532 |
| SEC24A | SEC24 family member A | 0.0239353 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0238743 |
| KRT18 | keratin 18, type I | 0.0237318 |
| EZR | ezrin | 0.0236834 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0232916 |
| GOLGA2 | golgin A2 | 0.0224386 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.022211 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0222031 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.022183 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0221447 |
| ANXA2 | annexin A2 | 0.0217257 |
| MKRN1 | makorin ring finger protein 1 | 0.0212964 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0211312 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0209583 |
| TPP2 | tripeptidyl peptidase II | 0.0208137 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0206822 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.0206299 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0205763 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.020552 |
| RPS2 | ribosomal protein S2 | 0.020552 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0203425 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0201222 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0200079 |
| TPM3 | tropomyosin 3 | 0.0199745 |
| TPM4 | tropomyosin 4 | 0.0199713 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0199137 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0197488 |
| PGM3 | phosphoglucomutase 3 | 0.0197159 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0196926 |
| HYOU1 | hypoxia up-regulated 1 | 0.0196126 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0195055 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0194929 |
| MXD1 | MAX dimerization protein 1 | 0.0194608 |
| RIOK3 | RIO kinase 3 | 0.0193788 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0193097 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0192653 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0192145 |
| SUCO | SUN domain containing ossification factor | 0.0191967 |
| JAG1 | jagged 1 | 0.0190351 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0190058 |
| RPL21 | ribosomal protein L21 | 0.0188934 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.018808 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.018712 |
| ITSN2 | intersectin 2 | 0.0186645 |
| ZNF292 | zinc finger protein 292 | 0.0185585 |
| RPL18 | ribosomal protein L18 | 0.0185255 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.310671 |
| RPL35A | ribosomal protein L35a | -0.19314 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.158062 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.134412 |
| ACTG1 | actin gamma 1 | -0.112983 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.106883 |
| NAV2 | neuron navigator 2 | -0.103971 |
| CCND1 | cyclin D1 | -0.0801767 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0796305 |
| WWOX | WW domain containing oxidoreductase | -0.0784505 |
| RPS6 | ribosomal protein S6 | -0.0782237 |
| RPLP1 | ribosomal protein, large, P1 | -0.0775297 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.07705 |
| RPS19 | ribosomal protein S19 | -0.0753864 |
| RPS23 | ribosomal protein S23 | -0.0721184 |
| RPS24 | ribosomal protein S24 | -0.0702722 |
| TMSB10 | thymosin beta 10 | -0.0687849 |
| SYT1 | synaptotagmin I | -0.0677457 |
| ACTN4 | actinin, alpha 4 | -0.0625512 |
| AHNAK | AHNAK nucleoprotein | -0.0617671 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0587587 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0555364 |
| RPL23 | ribosomal protein L23 | -0.0554144 |
| PTMA | prothymosin, alpha | -0.0547582 |
| RPL34 | ribosomal protein L34 | -0.0542677 |
| MT2A | metallothionein 2A | -0.0532043 |
| RPL38 | ribosomal protein L38 | -0.0518437 |
| CDK6 | cyclin-dependent kinase 6 | -0.0511926 |
| RPS11 | ribosomal protein S11 | -0.0482241 |
| TNS3 | tensin 3 | -0.0479416 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0476645 |
| RPL32 | ribosomal protein L32 | -0.0473187 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.046991 |
| RAD51B | RAD51 paralog B | -0.0462426 |
| RPS15 | ribosomal protein S15 | -0.0461383 |
| RPS21 | ribosomal protein S21 | -0.0456802 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0442043 |
| DEK | DEK proto-oncogene | -0.0441332 |
| MYO1D | myosin ID | -0.043113 |
| KRT8 | keratin 8, type II | -0.0408552 |
| RPLP2 | ribosomal protein, large, P2 | -0.0405507 |
| CDH13 | cadherin 13 | -0.0402114 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0400812 |
| S100A10 | S100 calcium binding protein A10 | -0.0400541 |
| RPL8 | ribosomal protein L8 | -0.0384086 |
| ATXN1 | ataxin 1 | -0.0383714 |
| SMYD3 | SET and MYND domain containing 3 | -0.0373538 |
| FHIT | fragile histidine triad | -0.0370168 |
| HMGB1 | high mobility group box 1 | -0.0368361 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0354027 |
| TMSB4X | thymosin beta 4, X-linked | -0.0353028 |
| CDK12 | cyclin-dependent kinase 12 | -0.0351235 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0348244 |
| RPS5 | ribosomal protein S5 | -0.0336875 |
| RUNX1 | runt-related transcription factor 1 | -0.0334198 |
| ASPH | aspartate beta-hydroxylase | -0.0333676 |
| MSI2 | musashi RNA-binding protein 2 | -0.033311 |
| FUS | FUS RNA binding protein | -0.0330275 |
| NOP56 | NOP56 ribonucleoprotein | -0.033005 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0329279 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0323011 |
| RPS29 | ribosomal protein S29 | -0.0321787 |
| RPS27A | ribosomal protein S27a | -0.031928 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0318824 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0312752 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0312642 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0309601 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0308172 |
| RPS13 | ribosomal protein S13 | -0.0307 |
| HDAC4 | histone deacetylase 4 | -0.030573 |
| H3-3B | H3.3 histone B | -0.0303476 |
| TCF12 | transcription factor 12 | -0.0302998 |
| RPL11 | ribosomal protein L11 | -0.0302737 |
| EXOC4 | exocyst complex component 4 | -0.0297697 |
| SYK | spleen tyrosine kinase | -0.0297044 |
| ZNRF3 | zinc and ring finger 3 | -0.0294681 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0292727 |
| RPL19 | ribosomal protein L19 | -0.0292254 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0291363 |
| TUBB | tubulin, beta class I | -0.029009 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.028984 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0289048 |
| AOPEP | aminopeptidase O (putative) | -0.028714 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0285205 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0284616 |
| IER3 | immediate early response 3 | -0.0281836 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0280273 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0277411 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0277248 |
| RBMX | RNA binding motif protein, X-linked | -0.0275059 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0274459 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0273798 |
| RPS10 | ribosomal protein S10 | -0.0273398 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0271333 |
| RPL12 | ribosomal protein L12 | -0.0269693 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0269004 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0265831 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0264787 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0262375 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0261537 |
