Canagliflozin (hemihydrate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin (hemihydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin (hemihydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.0810441
STC1 stanniocalcin 1 0.0732702
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0665004
ARHGAP21 Rho GTPase activating protein 21 0.0540517
FAM13A family with sequence similarity 13, member A 0.0476042
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0444132
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0425474
ATP13A3 ATPase type 13A3 0.0395763
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0360108
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0356811
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0349377
DNER delta/notch-like EGF repeat containing 0.0346147
JARID2 jumonji, AT rich interactive domain 2 0.0346061
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0345057
PDIA3 protein disulfide isomerase family A, member 3 0.0340471
HMGA2 high mobility group AT-hook 2 0.0329865
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0322466
MMP12 matrix metallopeptidase 12 0.0306064
GOLGA4 golgin A4 0.0303519
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0294664
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0292105
NGLY1 N-glycanase 1 0.0288329
COL6A2 collagen, type VI, alpha 2 0.0285862
TTC3 tetratricopeptide repeat domain 3 0.0282553
HILPDA hypoxia inducible lipid droplet-associated 0.0278281
CEMIP cell migration inducing protein, hyaluronan binding 0.026879
SRP54 signal recognition particle 54kDa 0.0245871
UBA6 ubiquitin-like modifier activating enzyme 6 0.024224
TMEM165 transmembrane protein 165 0.0240602
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0232016
PDE4D phosphodiesterase 4D, cAMP-specific 0.022961
MCL1 myeloid cell leukemia 1 0.0224379
APOLD1 apolipoprotein L domain containing 1 0.0224276
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0217443
TMF1 TATA element modulatory factor 1 0.0216541
IGFBP7 insulin-like growth factor binding protein 7 0.0215599
FNDC3A fibronectin type III domain containing 3A 0.0214302
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0214219
COG6 component of oligomeric golgi complex 6 0.0213608
ZCCHC7 zinc finger, CCHC domain containing 7 0.0212972
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0208199
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0206729
MORF4L2 mortality factor 4 like 2 0.020257
PGM3 phosphoglucomutase 3 0.0199501
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0198599
ADM adrenomedullin 0.0194382
NPTX1 neuronal pentraxin I 0.0192389
PDE8A phosphodiesterase 8A 0.0187999
VMP1 vacuole membrane protein 1 0.0185659
COPB1 coatomer protein complex, subunit beta 1 0.018453
TNPO1 transportin 1 0.0184491
STC2 stanniocalcin 2 0.0184314
FMNL2 formin-like 2 0.0182975
MEIS1 Meis homeobox 1 0.0179217
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0179079
FTH1 ferritin, heavy polypeptide 1 0.0174434
AFF3 AF4/FMR2 family, member 3 0.0173264
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0170742
ESYT2 extended synaptotagmin-like protein 2 0.0169432
CLINT1 clathrin interactor 1 0.0165974
RPS3 ribosomal protein S3 0.0161814
SOD2 superoxide dismutase 2, mitochondrial 0.0159903
HP1BP3 heterochromatin protein 1, binding protein 3 0.0159414
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0158794
RASA2 RAS p21 protein activator 2 0.0158531
HMGB2 high mobility group box 2 0.0157167
KMT2C lysine (K)-specific methyltransferase 2C 0.0155439
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0155303
CDC27 cell division cycle 27 0.015379
PICALM phosphatidylinositol binding clathrin assembly protein 0.0152608
HLA-E major histocompatibility complex, class I, E 0.0152074
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0151659
COL5A3 collagen, type V, alpha 3 0.0151427
MSI2 musashi RNA-binding protein 2 0.0147478
GPBP1 GC-rich promoter binding protein 1 0.0147141
TMEM39A transmembrane protein 39A 0.0146703
BZW1 basic leucine zipper and W2 domains 1 0.0146642
DSCAM Down syndrome cell adhesion molecule 0.0146456
COPA coatomer protein complex, subunit alpha 0.0145905
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0145799
FGFR1 fibroblast growth factor receptor 1 0.0145559
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0144544
KDM4C lysine (K)-specific demethylase 4C 0.0144208
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0142922
ACBD3 acyl-CoA binding domain containing 3 0.0142829
NPAS2 neuronal PAS domain protein 2 0.0139712
MON2 MON2 homolog (S. cerevisiae) 0.0139409
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0138934
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.013792
SUCO SUN domain containing ossification factor 0.0134754
PTPRK protein tyrosine phosphatase, receptor type, K 0.0134428
FNDC3B fibronectin type III domain containing 3B 0.0133123
MXI1 MAX interactor 1, dimerization protein 0.0132266
USP34 ubiquitin specific peptidase 34 0.013185
GPATCH2L G patch domain containing 2-like 0.0131801
NFE2L1 nuclear factor, erythroid 2-like 1 0.0131251
RNMT RNA (guanine-7-) methyltransferase 0.0130593
AKAP9 A kinase (PRKA) anchor protein 9 0.0129789
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0129433
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0129393

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.360278
COL6A3 collagen, type VI, alpha 3 -0.154692
FN1 fibronectin 1 -0.137061
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.102639
EMP1 epithelial membrane protein 1 -0.0841394
MT2A metallothionein 2A -0.0746522
ADGRB3 adhesion G protein-coupled receptor B3 -0.0723043
NALF1 NALCN channel auxiliary factor 1 -0.0633759
ACTG1 actin gamma 1 -0.0586948
AHNAK AHNAK nucleoprotein -0.0519673
CD44 CD44 molecule (Indian blood group) -0.0507569
TMSB10 thymosin beta 10 -0.0463033
MMP1 matrix metallopeptidase 1 -0.0453315
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0444018
ASPH aspartate beta-hydroxylase -0.0439992
COL1A1 collagen, type I, alpha 1 -0.0433734
INHBA inhibin, beta A -0.0424713
AKAP12 A kinase (PRKA) anchor protein 12 -0.0417068
NDRG1 N-myc downstream regulated 1 -0.0416896
SEPTIN11 septin 11 -0.037375
LOC112694756 uncharaterized LOC112694756 -0.0334539
GLIS3 GLIS family zinc finger 3 -0.0325468
EXT1 exostosin glycosyltransferase 1 -0.0325101
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0323902
RPS19 ribosomal protein S19 -0.032123
COL1A2 collagen, type I, alpha 2 -0.0316636
FTL ferritin, light polypeptide -0.030726
ABI3BP ABI family, member 3 (NESH) binding protein -0.030157
RAI14 retinoic acid induced 14 -0.0299054
MED13L mediator complex subunit 13-like -0.0298158
RPL35A ribosomal protein L35a -0.0297522
IER3 immediate early response 3 -0.0292788
LDHA lactate dehydrogenase A -0.0290206
EIF1 eukaryotic translation initiation factor 1 -0.0277382
HLA-B major histocompatibility complex, class I, B -0.0275353
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0270167
LOXL2 lysyl oxidase-like 2 -0.0263793
FRMD4A FERM domain containing 4A -0.0262068
COL6A1 collagen, type VI, alpha 1 -0.0259865
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0252504
RUNX1 runt-related transcription factor 1 -0.0249404
EPAS1 endothelial PAS domain protein 1 -0.0247843
ANXA2 annexin A2 -0.0243867
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0239264
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0234314
PRKG1 protein kinase, cGMP-dependent, type I -0.0233069
PKM pyruvate kinase, muscle -0.0228382
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0215008
B2M beta-2-microglobulin -0.0214477
SMAD3 SMAD family member 3 -0.0214374
NAV1 neuron navigator 1 -0.0210233
POTEF POTE ankyrin domain family, member F -0.0200589
TGFBI transforming growth factor, beta-induced, 68kDa -0.0199178
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0196919
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0194651
MYO10 myosin X -0.0194014
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0193879
MAP1B microtubule-associated protein 1B -0.0192407
CCND1 cyclin D1 -0.0191632
ARHGAP24 Rho GTPase activating protein 24 -0.0191203
ATP5F1B ATP synthase F1 subunit beta -0.0187891
CD59 CD59 molecule, complement regulatory protein -0.0186293
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0186257
CTSB cathepsin B -0.0186198
RPL19 ribosomal protein L19 -0.0182273
PGK1 phosphoglycerate kinase 1 -0.0180733
FRMD6 FERM domain containing 6 -0.0180349
LPP LIM domain containing preferred translocation partner in lipoma -0.0180288
FBN1 fibrillin 1 -0.0179829
FER fer (fps/fes related) tyrosine kinase -0.0172692
IL6 interleukin 6 -0.0171617
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0168846
VCAN versican -0.0167671
ANO6 anoctamin 6 -0.0166311
CALU calumenin -0.0159525
UBC ubiquitin C -0.0159463
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0159382
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0158746
DIAPH2 diaphanous-related formin 2 -0.0156162
RPL23 ribosomal protein L23 -0.0155727
IFIH1 interferon induced with helicase C domain 1 -0.0154023
COL3A1 collagen, type III, alpha 1 -0.0153945
MTPN myotrophin -0.0153027
ZEB1 zinc finger E-box binding homeobox 1 -0.015077
CALD1 caldesmon 1 -0.0148673
CCL5 chemokine (C-C motif) ligand 5 -0.0148444
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0148345
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0147785
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0143916
TUBB tubulin, beta class I -0.0142579
SAMD4A sterile alpha motif domain containing 4A -0.014175
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0141702
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0140606
RPL8 ribosomal protein L8 -0.0140299
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0140117
MYOF myoferlin -0.013991
S100A10 S100 calcium binding protein A10 -0.0138577
EGFR epidermal growth factor receptor -0.0136051
OXR1 oxidation resistance 1 -0.013586
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0133448