| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FBN1 | fibrillin 1 | 0.135345 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0863349 |
| MT2A | metallothionein 2A | 0.0745506 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0735626 |
| UBC | ubiquitin C | 0.0685576 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0632526 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0601806 |
| LOXL2 | lysyl oxidase-like 2 | 0.0584587 |
| ATP13A3 | ATPase type 13A3 | 0.0573542 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0571226 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0537201 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0515834 |
| GPC6 | glypican 6 | 0.0447372 |
| THBS2 | thrombospondin 2 | 0.0446954 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0444923 |
| SBF2 | SET binding factor 2 | 0.0427873 |
| APP | amyloid beta (A4) precursor protein | 0.0426395 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0415559 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0402365 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0398532 |
| OGA | O-GlcNAcase | 0.0394591 |
| DENND5A | DENN/MADD domain containing 5A | 0.0385357 |
| COL1A2 | collagen, type I, alpha 2 | 0.0383997 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0379042 |
| RNF145 | ring finger protein 145 | 0.0376695 |
| COL5A2 | collagen, type V, alpha 2 | 0.0364367 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0357753 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0356197 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0350861 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0348943 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0341394 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0336515 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0335553 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0324091 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0321642 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.032079 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0316723 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0312741 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0312188 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0311753 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0308542 |
| XPO1 | exportin 1 | 0.030567 |
| ARRDC3 | arrestin domain containing 3 | 0.0304937 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0302788 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0298516 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0294085 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0292847 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0291227 |
| WDFY1 | WD repeat and FYVE domain containing 1 | 0.0289411 |
| ENAH | enabled homolog (Drosophila) | 0.0282594 |
| ADM | adrenomedullin | 0.0282259 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0278821 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.027644 |
| WTAP | Wilms tumor 1 associated protein | 0.0272738 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0270907 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0270244 |
| COL3A1 | collagen, type III, alpha 1 | 0.0268098 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0267515 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0266293 |
| SETD5 | SET domain containing 5 | 0.0265416 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0261649 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0261632 |
| GOLGA4 | golgin A4 | 0.0261556 |
| SLC22A23 | solute carrier family 22, member 23 | 0.0259426 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0257564 |
| ANKRD33B | ankyrin repeat domain 33B | 0.025663 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0255842 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0255046 |
| IGF2R | insulin-like growth factor 2 receptor | 0.025472 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0253083 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0249442 |
| PLAT | plasminogen activator, tissue | 0.024779 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0246495 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0242346 |
| SP3 | Sp3 transcription factor | 0.0238342 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0238106 |
| ABI1 | abl-interactor 1 | 0.0237466 |
| UBE2O | ubiquitin-conjugating enzyme E2O | 0.0237025 |
| DTNA | dystrobrevin, alpha | 0.0236624 |
| TPR | translocated promoter region, nuclear basket protein | 0.0235733 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0234967 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0233617 |
| MB21D2 | Mab-21 domain containing 2 | 0.02322 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0232117 |
| SKIC3 | SKI3 subunit of superkiller complex | 0.0228303 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0226493 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0226031 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0225779 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0225168 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0224566 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0223252 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0222955 |
| PCGF5 | polycomb group ring finger 5 | 0.0222368 |
| USP3 | ubiquitin specific peptidase 3 | 0.0221388 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0220252 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0219496 |
| TMSB10 | thymosin beta 10 | 0.0219162 |
| HELZ | helicase with zinc finger | 0.0219151 |
| NDRG1 | N-myc downstream regulated 1 | 0.0218979 |
| B2M | beta-2-microglobulin | 0.0217568 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.205913 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.165639 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.159905 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.126869 |
| PODXL | podocalyxin-like | -0.116726 |
| MAP1B | microtubule-associated protein 1B | -0.115606 |
| CDH13 | cadherin 13 | -0.11385 |
| EGFR | epidermal growth factor receptor | -0.0882613 |
| POTEF | POTE ankyrin domain family, member F | -0.086024 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0742276 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.071508 |
| TPM4 | tropomyosin 4 | -0.0694926 |
| NAV1 | neuron navigator 1 | -0.0681249 |
| FN1 | fibronectin 1 | -0.0640718 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0574349 |
| SUCNR1 | succinate receptor 1 | -0.0520807 |
| LOX | lysyl oxidase | -0.0511018 |
| COL5A1 | collagen, type V, alpha 1 | -0.0495381 |
| CCND1 | cyclin D1 | -0.0472401 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0460713 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0450547 |
| S100A10 | S100 calcium binding protein A10 | -0.0436069 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0431094 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0414415 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0399606 |
| S100A6 | S100 calcium binding protein A6 | -0.0398284 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0397162 |
| MYADM | myeloid-associated differentiation marker | -0.0392826 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0377132 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0357547 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0356078 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0334715 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0332695 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0331227 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0323545 |
| EFNA5 | ephrin-A5 | -0.0323466 |
| CSTB | cystatin B (stefin B) | -0.0311125 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0305738 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0303675 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0297385 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0290659 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.028459 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0281051 |
| ANXA2 | annexin A2 | -0.0280567 |
| LRRC17 | leucine rich repeat containing 17 | -0.0273495 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0272428 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0267978 |
| ASPH | aspartate beta-hydroxylase | -0.0267855 |
| CYTH3 | cytohesin 3 | -0.0258763 |
| TAGLN2 | transgelin 2 | -0.025493 |
| PFN1 | profilin 1 | -0.0252813 |
| IL7R | interleukin 7 receptor | -0.0249229 |
| CANX | calnexin | -0.0248885 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0248262 |
| AHNAK | AHNAK nucleoprotein | -0.0248149 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0245876 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0241559 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0233842 |
| PLXNA2 | plexin A2 | -0.0233231 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.0230514 |
| DCLK2 | doublecortin-like kinase 2 | -0.0225366 |
| HDAC9 | histone deacetylase 9 | -0.02239 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0223683 |
| PKM | pyruvate kinase, muscle | -0.0222229 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0218754 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0218311 |
| GOLGB1 | golgin B1 | -0.0217008 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0213747 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0213266 |
| PRKCE | protein kinase C, epsilon | -0.0212724 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0210681 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0206268 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0206223 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0206102 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0203832 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0203098 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | -0.0200406 |
| CD44 | CD44 molecule (Indian blood group) | -0.0199491 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0190295 |
| HLCS | holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) | -0.0189962 |
| KRT81 | keratin 81, type II | -0.0188284 |
| CDK6 | cyclin-dependent kinase 6 | -0.0185666 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.018544 |
| SP100 | SP100 nuclear antigen | -0.0185123 |
| TPM3 | tropomyosin 3 | -0.0184342 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0184189 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.01831 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | -0.0182564 |
| CALR | calreticulin | -0.0181626 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0180543 |
| E2F7 | E2F transcription factor 7 | -0.0180176 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0179531 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0179283 |
| PCDH7 | protocadherin 7 | -0.0178658 |
| KIAA1549L | KIAA1549-like | -0.0178643 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0176605 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0176319 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0175429 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0175097 |
| EHBP1 | EH domain binding protein 1 | -0.0174361 |
