| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.107504 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0663541 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0653147 |
| ANXA1 | annexin A1 | 0.0590854 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0586131 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0571085 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0560628 |
| AREG | amphiregulin | 0.0516401 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0513802 |
| TMEM41B | transmembrane protein 41B | 0.0507647 |
| ECT2 | epithelial cell transforming 2 | 0.0506405 |
| MED13L | mediator complex subunit 13-like | 0.0489216 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.048538 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0481984 |
| YBX3 | Y box binding protein 3 | 0.0453012 |
| MKI67 | marker of proliferation Ki-67 | 0.0444957 |
| CXADR | coxsackie virus and adenovirus receptor | 0.044133 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0433258 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0420562 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.0415374 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.040924 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0408617 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0404102 |
| LMO7 | LIM domain 7 | 0.0402474 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0398875 |
| XPO1 | exportin 1 | 0.0398271 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.039143 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0387031 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0375684 |
| CDK17 | cyclin-dependent kinase 17 | 0.0374543 |
| CCNL1 | cyclin L1 | 0.0370232 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0361491 |
| TNPO1 | transportin 1 | 0.0355946 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0343529 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0342407 |
| RBM39 | RNA binding motif protein 39 | 0.0341102 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.032983 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0324276 |
| NEK7 | NIMA-related kinase 7 | 0.0313989 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | 0.0312006 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0311475 |
| SPAG9 | sperm associated antigen 9 | 0.0306688 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0304219 |
| GASK1B | golgi associated kinase 1B | 0.0294972 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0291469 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0289413 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.028938 |
| ZNF217 | zinc finger protein 217 | 0.028385 |
| CPOX | coproporphyrinogen oxidase | 0.0280637 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.027491 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0261979 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0259897 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0259864 |
| DST | dystonin | 0.0259278 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0256477 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | 0.0253751 |
| H1-0 | H1.0 linker histone | 0.0250473 |
| CENPF | centromere protein F, 350/400kDa | 0.0249069 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0248943 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0245501 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0241715 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0240623 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | 0.0234751 |
| WDR43 | WD repeat domain 43 | 0.0234235 |
| AXIN2 | axin 2 | 0.0230712 |
| OXR1 | oxidation resistance 1 | 0.0224277 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0223777 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0221823 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0219222 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0219189 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0215779 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0214245 |
| TPR | translocated promoter region, nuclear basket protein | 0.0214245 |
| NDC80 | NDC80 kinetochore complex component | 0.0214172 |
| MATR3 | matrin 3 | 0.0212333 |
| QKI | QKI, KH domain containing, RNA binding | 0.0211152 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0209777 |
| CEP192 | centrosomal protein 192kDa | 0.0209756 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0209292 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0209137 |
| KIF5B | kinesin family member 5B | 0.0208412 |
| PDGFC | platelet derived growth factor C | 0.0208233 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0207112 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0206858 |
| RTN4 | reticulon 4 | 0.0205647 |
| TPX2 | TPX2, microtubule-associated | 0.0205237 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0204311 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.020407 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.0203232 |
| CEP70 | centrosomal protein 70kDa | 0.02024 |
| KIF18B | kinesin family member 18B | 0.020162 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0201328 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0201183 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0201083 |
| ELP2 | elongator acetyltransferase complex subunit 2 | 0.019616 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0195275 |
| HMGB2 | high mobility group box 2 | 0.0193868 |
| MPG | N-methylpurine-DNA glycosylase | 0.0192889 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0192886 |
| VMP1 | vacuole membrane protein 1 | 0.0192183 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.24966 |
| VIM | vimentin | -0.184879 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.136711 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.115629 |
| HMGA2 | high mobility group AT-hook 2 | -0.0962149 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0734326 |
| ACTG1 | actin gamma 1 | -0.0699471 |
| RAB7A | RAB7A, member RAS oncogene family | -0.066667 |
| EHBP1 | EH domain binding protein 1 | -0.0662719 |
| EGR1 | early growth response 1 | -0.0639253 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0588495 |
| POTEF | POTE ankyrin domain family, member F | -0.0522449 |
| HMGA1 | high mobility group AT-hook 1 | -0.0492995 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0471624 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0446176 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0416853 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.041098 |
| ADIPOR2 | adiponectin receptor 2 | -0.0382994 |
| TUBA1B | tubulin, alpha 1b | -0.0374375 |
| INTS6 | integrator complex subunit 6 | -0.0353445 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0335329 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0308686 |
| PFN1 | profilin 1 | -0.0308361 |
| PCDH7 | protocadherin 7 | -0.0301439 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0298597 |
| RPS8 | ribosomal protein S8 | -0.0291996 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0287522 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0287434 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.028492 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0269295 |
| LRRC23 | leucine rich repeat containing 23 | -0.0250999 |
| BPTF | bromodomain PHD finger transcription factor | -0.0247009 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0236056 |
| RPS6 | ribosomal protein S6 | -0.0231879 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0229919 |
| CCN2 | cellular communication network factor 2 | -0.022953 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0225616 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0222791 |
| BCHE | butyrylcholinesterase | -0.0215593 |
| TBCA | tubulin folding cofactor A | -0.0215169 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0214738 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0208682 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0208277 |
| TPM4 | tropomyosin 4 | -0.0201553 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.020115 |
| HLA-A | major histocompatibility complex, class I, A | -0.020002 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0198588 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0196916 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0195749 |
| R3HDM2 | R3H domain containing 2 | -0.0195676 |
| CUX1 | cut-like homeobox 1 | -0.0195462 |
| TPM3 | tropomyosin 3 | -0.0190185 |
| MYADM | myeloid-associated differentiation marker | -0.018951 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0189375 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0189221 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0188562 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0187863 |
| GOLGB1 | golgin B1 | -0.0187263 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0186074 |
| BRD2 | bromodomain containing 2 | -0.0184904 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.018352 |
| MORF4L2 | mortality factor 4 like 2 | -0.0182448 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0181654 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0181332 |
| MMP12 | matrix metallopeptidase 12 | -0.0180875 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0178147 |
| PRDX1 | peroxiredoxin 1 | -0.0177869 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0176945 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0176285 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0175511 |
| RPS13 | ribosomal protein S13 | -0.0175509 |
| ASXL2 | additional sex combs like transcriptional regulator 2 | -0.0174298 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0173813 |
| ZNF638 | zinc finger protein 638 | -0.0173164 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0169072 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0168668 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0168191 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0167943 |
| RPL37A | ribosomal protein L37a | -0.0167728 |
| RACK1 | receptor for activated C kinase 1 | -0.0164881 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0162948 |
| CANX | calnexin | -0.0162522 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0158499 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0157489 |
| EGFR | epidermal growth factor receptor | -0.0156314 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0154557 |
| SON | SON DNA binding protein | -0.0152948 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0152936 |
| SERTAD2 | SERTA domain containing 2 | -0.0152303 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0152166 |
| RHOA | ras homolog family member A | -0.0151614 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0150266 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0149926 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0149781 |
| S100A6 | S100 calcium binding protein A6 | -0.0148896 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0148532 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0147259 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | -0.0146075 |
| RPL35A | ribosomal protein L35a | -0.0145069 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0144988 |
