| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.475233 |
| PTMA | prothymosin, alpha | 0.0777287 |
| LPIN1 | lipin 1 | 0.0731944 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0711324 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0650182 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0645031 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0607867 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0533105 |
| GOLGA4 | golgin A4 | 0.0517905 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0504064 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0494486 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0492881 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0486643 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0469947 |
| MEIS2 | Meis homeobox 2 | 0.0467372 |
| CD36 | CD36 molecule (thrombospondin receptor) | 0.0456908 |
| MAP1B | microtubule-associated protein 1B | 0.0444995 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0434698 |
| MYO6 | myosin VI | 0.043159 |
| CLTC | clathrin, heavy chain (Hc) | 0.0423821 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0403809 |
| NUP58 | nucleoporin 58 | 0.0396109 |
| SET | SET nuclear proto-oncogene | 0.038167 |
| APP | amyloid beta (A4) precursor protein | 0.0380786 |
| HELZ | helicase with zinc finger | 0.0358422 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.03484 |
| COL1A1 | collagen, type I, alpha 1 | 0.0340417 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0333139 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.0332481 |
| ENAH | enabled homolog (Drosophila) | 0.03295 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0328981 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0327328 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0327314 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0324676 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0320729 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0313743 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0310696 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0308871 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0308566 |
| PTEN | phosphatase and tensin homolog | 0.0305342 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0304884 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.030477 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0304703 |
| USP3 | ubiquitin specific peptidase 3 | 0.0293093 |
| TPR | translocated promoter region, nuclear basket protein | 0.0287857 |
| RPS6 | ribosomal protein S6 | 0.0278913 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0277773 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.027713 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0273892 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0271219 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0266767 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0266435 |
| PGK1 | phosphoglycerate kinase 1 | 0.0265055 |
| IGF2 | insulin-like growth factor 2 | 0.0262413 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0259831 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0259799 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0259343 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0257727 |
| PDS5B | PDS5 cohesin associated factor B | 0.0255032 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | 0.0254777 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0253571 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0253144 |
| RPL7 | ribosomal protein L7 | 0.0253008 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.0250924 |
| GNG2 | guanine nucleotide binding protein (G protein), gamma 2 | 0.0244132 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0243922 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0242277 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0242021 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0241582 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0241135 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0240749 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0240535 |
| PTK2 | protein tyrosine kinase 2 | 0.023818 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | 0.023793 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0236424 |
| ZFHX3 | zinc finger homeobox 3 | 0.0235765 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0235673 |
| ARRDC3 | arrestin domain containing 3 | 0.0234301 |
| NBAS | neuroblastoma amplified sequence | 0.0232408 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0228665 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0226909 |
| CBX3 | chromobox homolog 3 | 0.0225424 |
| MORF4L1 | mortality factor 4 like 1 | 0.022527 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0224994 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | 0.0224681 |
| RPL23 | ribosomal protein L23 | 0.0221879 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | 0.0221835 |
| FNBP4 | formin binding protein 4 | 0.0221422 |
| TXNL1 | thioredoxin-like 1 | 0.0220369 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.021967 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0217929 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.0217888 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0216477 |
| PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 0.0215682 |
| RPL34 | ribosomal protein L34 | 0.0214807 |
| WRN | Werner syndrome, RecQ helicase-like | 0.0214755 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0214193 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0213952 |
| NOP58 | NOP58 ribonucleoprotein | 0.021394 |
| SLMAP | sarcolemma associated protein | 0.0211032 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VCL | vinculin | -0.194076 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.102878 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0984473 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0943184 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0776261 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0749324 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0688778 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0688149 |
| LSAMP | limbic system-associated membrane protein | -0.0673398 |
| TRIB2 | tribbles pseudokinase 2 | -0.0558502 |
| TLE4 | transducin-like enhancer of split 4 | -0.0556827 |
| TPM1 | tropomyosin 1 (alpha) | -0.0492808 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0477521 |
| NRG1 | neuregulin 1 | -0.0440424 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0439301 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0438098 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0413392 |
| SYT1 | synaptotagmin I | -0.0404917 |
| INTS6 | integrator complex subunit 6 | -0.040441 |
| MYO1E | myosin IE | -0.0395713 |
| ST6GALNAC3 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 | -0.0394492 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | -0.0379267 |
| VMP1 | vacuole membrane protein 1 | -0.0366047 |
| MCL1 | myeloid cell leukemia 1 | -0.0364015 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0356607 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0336683 |
| AEBP2 | AE binding protein 2 | -0.0334118 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0333711 |
| RAD51B | RAD51 paralog B | -0.0329802 |
| EGR1 | early growth response 1 | -0.0328646 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0321202 |
| MAPK10 | mitogen-activated protein kinase 10 | -0.031832 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0313728 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0312617 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0309993 |
| SMYD3 | SET and MYND domain containing 3 | -0.0302857 |
| RNF150 | ring finger protein 150 | -0.03013 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0298496 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0293637 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0288494 |
| ARF1 | ADP-ribosylation factor 1 | -0.0284699 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0276765 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0275616 |
| ACTN1 | actinin, alpha 1 | -0.0269236 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0267298 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0267015 |
| THBS1 | thrombospondin 1 | -0.026641 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0265972 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0264863 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0260046 |
| NDRG1 | N-myc downstream regulated 1 | -0.0259762 |
| NREP | neuronal regeneration related protein | -0.0258683 |
| STK38L | serine/threonine kinase 38 like | -0.0255938 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0255757 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0255515 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0251174 |
| UBAP2 | ubiquitin associated protein 2 | -0.0249403 |
| FERMT2 | fermitin family member 2 | -0.0249017 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0248824 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0247952 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0240552 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0239088 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0238408 |
| PRKCA | protein kinase C, alpha | -0.0235886 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0233237 |
| LARGE1 | LARGE xylosyl- and glucuronyltransferase 1 | -0.0233225 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0231644 |
| RGS4 | regulator of G-protein signaling 4 | -0.0227822 |
| WDR1 | WD repeat domain 1 | -0.0227616 |
| KCTD16 | potassium channel tetramerization domain containing 16 | -0.0225562 |
| TUFT1 | tuftelin 1 | -0.0224723 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0222502 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0221377 |
| PCDH10 | protocadherin 10 | -0.0219697 |
| PCBP3 | poly(rC) binding protein 3 | -0.021874 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0218248 |
| ATRNL1 | attractin-like 1 | -0.0217779 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0217606 |
| IER3 | immediate early response 3 | -0.0217173 |
| GSE1 | Gse1 coiled-coil protein | -0.0217165 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.021598 |
| GPC5 | glypican 5 | -0.0215805 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0215079 |
| CUX1 | cut-like homeobox 1 | -0.0214374 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0212671 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0210993 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0206624 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0204509 |
| TBCA | tubulin folding cofactor A | -0.020355 |
| SCFD1 | sec1 family domain containing 1 | -0.0203385 |
| NBEA | neurobeachin | -0.0202125 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0201599 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0199027 |
| EGFR | epidermal growth factor receptor | -0.0198894 |
| CORIN | corin, serine peptidase | -0.0196208 |
| CEP112 | centrosomal protein 112kDa | -0.019451 |
| RIGI | RNA sensor RIG-I | -0.0194184 |
| FMN1 | formin 1 | -0.0194065 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0193973 |
| FAM107B | family with sequence similarity 107, member B | -0.0193296 |
