| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.135418 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.122895 |
| COL6A3 | collagen, type VI, alpha 3 | 0.115927 |
| EXT1 | exostosin glycosyltransferase 1 | 0.073491 |
| FN1 | fibronectin 1 | 0.0570041 |
| MT2A | metallothionein 2A | 0.05299 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0499709 |
| SMAD3 | SMAD family member 3 | 0.0492392 |
| MSN | moesin | 0.046452 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0447598 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0426781 |
| CLIC4 | chloride intracellular channel 4 | 0.0423216 |
| PRELID2 | PRELI domain containing 2 | 0.0408644 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0403986 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0374727 |
| CDH13 | cadherin 13 | 0.0371268 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0352283 |
| ATP13A3 | ATPase type 13A3 | 0.0325829 |
| FAT1 | FAT atypical cadherin 1 | 0.0323283 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0321763 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0316955 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0314721 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0307443 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0305334 |
| ANTXR2 | anthrax toxin receptor 2 | 0.030102 |
| ARRDC3 | arrestin domain containing 3 | 0.0292332 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0284751 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.0272024 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0268389 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0259712 |
| MTSS1 | metastasis suppressor 1 | 0.0257866 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0256434 |
| PDE10A | phosphodiesterase 10A | 0.0251521 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0248065 |
| HAS2 | hyaluronan synthase 2 | 0.024628 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.024361 |
| NAV1 | neuron navigator 1 | 0.0242422 |
| VMP1 | vacuole membrane protein 1 | 0.0241529 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0237262 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0236071 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0231613 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0230804 |
| PTK2 | protein tyrosine kinase 2 | 0.022306 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0218674 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0217848 |
| PLEC | plectin | 0.0212665 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0212277 |
| STC1 | stanniocalcin 1 | 0.0209283 |
| ADAM12 | ADAM metallopeptidase domain 12 | 0.0208859 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0208195 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0207073 |
| FLNA | filamin A, alpha | 0.0205567 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0204555 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0200079 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0198454 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0197455 |
| HMGA2 | high mobility group AT-hook 2 | 0.019728 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0194032 |
| MKI67 | marker of proliferation Ki-67 | 0.0193415 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0192452 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0190973 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0190678 |
| ATXN1 | ataxin 1 | 0.0188113 |
| YEATS2 | YEATS domain containing 2 | 0.0187883 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0186166 |
| KIAA1217 | KIAA1217 | 0.0185747 |
| AMOTL1 | angiomotin like 1 | 0.0185409 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.018439 |
| AXL | AXL receptor tyrosine kinase | 0.0184312 |
| SQLE | squalene epoxidase | 0.0184258 |
| VEGFC | vascular endothelial growth factor C | 0.0181121 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.0179683 |
| VEGFA | vascular endothelial growth factor A | 0.0177831 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0177642 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0176569 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0176341 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.01725 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0169864 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0168956 |
| GLIS3 | GLIS family zinc finger 3 | 0.0168013 |
| ACTN4 | actinin, alpha 4 | 0.0167358 |
| RPL3 | ribosomal protein L3 | 0.0166461 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0165599 |
| KLF12 | Kruppel-like factor 12 | 0.0165012 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0164549 |
| TMF1 | TATA element modulatory factor 1 | 0.0164517 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0164461 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0164431 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0163979 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0163121 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0162323 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0159477 |
| TBC1D23 | TBC1 domain family, member 23 | 0.0158957 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0157896 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0155562 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0153421 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | 0.0151599 |
| INHBA | inhibin, beta A | 0.015127 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0149439 |
| LOXL2 | lysyl oxidase-like 2 | 0.0149145 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.338748 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.195731 |
| VIM | vimentin | -0.132326 |
| CANX | calnexin | -0.0721029 |
| COL1A1 | collagen, type I, alpha 1 | -0.0711 |
| NDRG1 | N-myc downstream regulated 1 | -0.0686312 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0684293 |
| IER3 | immediate early response 3 | -0.0583809 |
| CADM1 | cell adhesion molecule 1 | -0.0500416 |
| RPL35A | ribosomal protein L35a | -0.0482787 |
| TMSB10 | thymosin beta 10 | -0.0476991 |
| PTMA | prothymosin, alpha | -0.0423341 |
| FTL | ferritin, light polypeptide | -0.04125 |
| COL1A2 | collagen, type I, alpha 2 | -0.0405845 |
| MTDH | metadherin | -0.0382858 |
| LMAN1 | lectin, mannose-binding, 1 | -0.037894 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0359118 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0358896 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0338216 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.033681 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0318017 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0317338 |
| COL3A1 | collagen, type III, alpha 1 | -0.0316761 |
| AHNAK | AHNAK nucleoprotein | -0.0301195 |
| SQSTM1 | sequestosome 1 | -0.0297549 |
| ACTG1 | actin gamma 1 | -0.0287135 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0284193 |
| HLA-B | major histocompatibility complex, class I, B | -0.0278736 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0271208 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0269137 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0264558 |
| HDLBP | high density lipoprotein binding protein | -0.0259539 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0254535 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0253922 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0251057 |
| RPS8 | ribosomal protein S8 | -0.0249357 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0243685 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0236596 |
| SEPTIN7 | septin 7 | -0.0233292 |
| TMEM263 | transmembrane protein 263 | -0.023299 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0232039 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0228435 |
| MATR3 | matrin 3 | -0.0219667 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0219348 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0215872 |
| FAM162A | family with sequence similarity 162, member A | -0.0211246 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.021021 |
| MAP4 | microtubule-associated protein 4 | -0.0209565 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0209329 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0208027 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0207989 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0203718 |
| FBN1 | fibrillin 1 | -0.0202755 |
| ANXA2 | annexin A2 | -0.0200649 |
| S100A6 | S100 calcium binding protein A6 | -0.0196032 |
| RPL34 | ribosomal protein L34 | -0.0193963 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0193037 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0192599 |
| TRAM1 | translocation associated membrane protein 1 | -0.0191292 |
| RPS24 | ribosomal protein S24 | -0.0187476 |
| RTN3 | reticulon 3 | -0.0186533 |
| SP100 | SP100 nuclear antigen | -0.0186281 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0185181 |
| TPM4 | tropomyosin 4 | -0.0184564 |
| HIP1 | huntingtin interacting protein 1 | -0.018347 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0183193 |
| CALR | calreticulin | -0.0182259 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0177006 |
| GNAS | GNAS complex locus | -0.0176652 |
| SRP72 | signal recognition particle 72kDa | -0.0176508 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0173661 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0173517 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0173435 |
| GNL3 | guanine nucleotide binding protein-like 3 (nucleolar) | -0.0171072 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0169838 |
| RPLP1 | ribosomal protein, large, P1 | -0.0169628 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0168919 |
| HELZ | helicase with zinc finger | -0.0168875 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0164038 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0164009 |
| RYBP | RING1 and YY1 binding protein | -0.016103 |
| HMGB1 | high mobility group box 1 | -0.0160832 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0159541 |
| PXDN | peroxidasin | -0.0159211 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.0158311 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0157694 |
| CAVIN1 | caveolae associated protein 1 | -0.0157499 |
| RPL12 | ribosomal protein L12 | -0.0156773 |
| TFG | TRK-fused gene | -0.0156581 |
| QKI | QKI, KH domain containing, RNA binding | -0.0156398 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0156387 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0156073 |
| OXR1 | oxidation resistance 1 | -0.0154855 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0154382 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0154135 |
| GOLGB1 | golgin B1 | -0.0152469 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0151898 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0151567 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0150871 |
| RPS6 | ribosomal protein S6 | -0.0149802 |
