| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.251405 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.223114 |
| IGF2 | insulin-like growth factor 2 | 0.166352 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.122621 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.120711 |
| FNDC3B | fibronectin type III domain containing 3B | 0.111642 |
| SLC38A2 | solute carrier family 38, member 2 | 0.102681 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0957455 |
| GPC6 | glypican 6 | 0.0951034 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0935366 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0850875 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0821481 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0818653 |
| EHBP1 | EH domain binding protein 1 | 0.0774203 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0665828 |
| MSI2 | musashi RNA-binding protein 2 | 0.0631272 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0625295 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0622008 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0618465 |
| PEG3 | paternally expressed 3 | 0.0599648 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0582995 |
| ATXN1 | ataxin 1 | 0.0559508 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0530971 |
| ITGAV | integrin, alpha V | 0.0515994 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0507971 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0506192 |
| TF | transferrin | 0.0485247 |
| PLIN2 | perilipin 2 | 0.0482857 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0482821 |
| DST | dystonin | 0.0470132 |
| NHSL1 | NHS-like 1 | 0.0469447 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0466855 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0460427 |
| FRMD5 | FERM domain containing 5 | 0.04598 |
| RUNX1 | runt-related transcription factor 1 | 0.0449131 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0448164 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0446118 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0445742 |
| ATP10A | ATPase, class V, type 10A | 0.0436069 |
| ASPH | aspartate beta-hydroxylase | 0.0431719 |
| FMNL2 | formin-like 2 | 0.0424279 |
| FAT1 | FAT atypical cadherin 1 | 0.041106 |
| AFDN | afadin, adherens junction formation factor | 0.0402575 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.039554 |
| KIF1B | kinesin family member 1B | 0.0388416 |
| DTNA | dystrobrevin, alpha | 0.0387296 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0386803 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0384925 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | 0.0381803 |
| CP | ceruloplasmin (ferroxidase) | 0.0376502 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0375377 |
| ARFGEF3 | ARFGEF family member 3 | 0.0364751 |
| PARD3 | par-3 family cell polarity regulator | 0.035861 |
| AHR | aryl hydrocarbon receptor | 0.0356018 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0349801 |
| WAC | WW domain containing adaptor with coiled-coil | 0.034748 |
| FAM135A | family with sequence similarity 135, member A | 0.0342372 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.032904 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0328793 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0328351 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0326836 |
| MCL1 | myeloid cell leukemia 1 | 0.032212 |
| VCL | vinculin | 0.0318871 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0318714 |
| KIAA1217 | KIAA1217 | 0.0316481 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0311904 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0310534 |
| DENND4A | DENN/MADD domain containing 4A | 0.0304039 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.030276 |
| STK17A | serine/threonine kinase 17a | 0.0301646 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0298984 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0296647 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0295674 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0294964 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0294763 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0293595 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.028901 |
| TNS3 | tensin 3 | 0.0285926 |
| PLXDC2 | plexin domain containing 2 | 0.0284808 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.02835 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0277948 |
| TPM4 | tropomyosin 4 | 0.0275236 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.0274921 |
| CDK19 | cyclin-dependent kinase 19 | 0.0274647 |
| TRIM24 | tripartite motif containing 24 | 0.027379 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.027365 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.0273171 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0272893 |
| SRPK1 | SRSF protein kinase 1 | 0.0272518 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0271952 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0269854 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.026618 |
| RNF213 | ring finger protein 213 | 0.0257766 |
| STK39 | serine threonine kinase 39 | 0.0257012 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0255611 |
| TNS1 | tensin 1 | 0.0253769 |
| FOXN3 | forkhead box N3 | 0.025362 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.0252037 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0250341 |
| ACTN4 | actinin, alpha 4 | 0.0248284 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0879372 |
| MT2A | metallothionein 2A | -0.0825936 |
| RPS6 | ribosomal protein S6 | -0.0679172 |
| RPS2 | ribosomal protein S2 | -0.059338 |
| RPS12 | ribosomal protein S12 | -0.0571953 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.054464 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.049908 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0472325 |
| RPLP1 | ribosomal protein, large, P1 | -0.0460935 |
| SDC4 | syndecan 4 | -0.0432279 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0416604 |
| RPS8 | ribosomal protein S8 | -0.0401047 |
| RPL11 | ribosomal protein L11 | -0.0395096 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0393541 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0371753 |
| RPLP2 | ribosomal protein, large, P2 | -0.0367449 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0367079 |
| RPL37A | ribosomal protein L37a | -0.0357106 |
| RPL5 | ribosomal protein L5 | -0.0340442 |
| RPL38 | ribosomal protein L38 | -0.032468 |
| JAK1 | Janus kinase 1 | -0.0316223 |
| C3 | complement component 3 | -0.0316121 |
| RPL9 | ribosomal protein L9 | -0.0314823 |
| RPL26 | ribosomal protein L26 | -0.0300115 |
| RPS3 | ribosomal protein S3 | -0.0299119 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0283837 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0282215 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.028152 |
| RPL36 | ribosomal protein L36 | -0.0275751 |
| RPS19 | ribosomal protein S19 | -0.0269277 |
| RBM39 | RNA binding motif protein 39 | -0.0267389 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0254735 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0254024 |
| RPL7 | ribosomal protein L7 | -0.025303 |
| SVIL | supervillin | -0.0244642 |
| WDR45B | WD repeat domain 45B | -0.0241802 |
| MATR3 | matrin 3 | -0.0238308 |
| LCN2 | lipocalin 2 | -0.0235824 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0235095 |
| RPL19 | ribosomal protein L19 | -0.0232674 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0230199 |
| NCKAP1 | NCK-associated protein 1 | -0.0229181 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0223856 |
| PAPOLA | poly(A) polymerase alpha | -0.022291 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0221935 |
| RPS13 | ribosomal protein S13 | -0.0220619 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.0220523 |
| BCL2L1 | BCL2-like 1 | -0.0219032 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0213657 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0210933 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.021034 |
| RRBP1 | ribosome binding protein 1 | -0.0210289 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | -0.0208018 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0205455 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | -0.0204482 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0204394 |
| RPL4 | ribosomal protein L4 | -0.0204361 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 | -0.0203867 |
| CLU | clusterin | -0.0200637 |
| GPHN | gephyrin | -0.0199039 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0198874 |
| CUL3 | cullin 3 | -0.0197617 |
| SETD5 | SET domain containing 5 | -0.0197029 |
| FUS | FUS RNA binding protein | -0.0196116 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0195827 |
| RPL6 | ribosomal protein L6 | -0.0194274 |
| YLPM1 | YLP motif containing 1 | -0.0192181 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | -0.0190944 |
| CSNK1G3 | casein kinase 1, gamma 3 | -0.0190578 |
| OLA1 | Obg-like ATPase 1 | -0.0189016 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0188032 |
| RPL18 | ribosomal protein L18 | -0.01878 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0187135 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0184665 |
| RPS15 | ribosomal protein S15 | -0.0182842 |
| GOLGA4 | golgin A4 | -0.0182738 |
| FGG | fibrinogen gamma chain | -0.0181728 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | -0.0180837 |
| YBX3 | Y box binding protein 3 | -0.0179767 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0177886 |
| RPL21 | ribosomal protein L21 | -0.0177289 |
| CANX | calnexin | -0.0177257 |
| PTMA | prothymosin, alpha | -0.0175435 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0173165 |
| BRD4 | bromodomain containing 4 | -0.0170803 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.0170694 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0169786 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0169535 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0169195 |
| VGLL4 | vestigial-like family member 4 | -0.0168822 |
| SPAG9 | sperm associated antigen 9 | -0.0167926 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0167883 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0167782 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0166556 |
| SET | SET nuclear proto-oncogene | -0.0166363 |
| RPS4X | ribosomal protein S4, X-linked | -0.0165837 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0165615 |
| RPS29 | ribosomal protein S29 | -0.0165091 |
| ZFR | zinc finger RNA binding protein | -0.0164752 |
| CDC27 | cell division cycle 27 | -0.0164616 |
