| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FAT1 | FAT atypical cadherin 1 | 0.122046 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0978478 |
| EREG | epiregulin | 0.0971882 |
| VCL | vinculin | 0.0899905 |
| PIGR | polymeric immunoglobulin receptor | 0.0857546 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0795097 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0755982 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0744692 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0736881 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0704554 |
| AREG | amphiregulin | 0.069943 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0613928 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0600375 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0596095 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0588849 |
| RNF145 | ring finger protein 145 | 0.0576893 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0558712 |
| RREB1 | ras responsive element binding protein 1 | 0.0556009 |
| RBM39 | RNA binding motif protein 39 | 0.0532465 |
| MED13L | mediator complex subunit 13-like | 0.053231 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0531821 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0526707 |
| MYO1E | myosin IE | 0.052287 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0516962 |
| RPS12 | ribosomal protein S12 | 0.0513641 |
| CCNL1 | cyclin L1 | 0.0497377 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0497075 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0496304 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0494987 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.049471 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0480449 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0480113 |
| VEGFA | vascular endothelial growth factor A | 0.0478632 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0477768 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0460781 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0452446 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0450934 |
| MCL1 | myeloid cell leukemia 1 | 0.0447868 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0447512 |
| ACTN4 | actinin, alpha 4 | 0.0443014 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0439778 |
| RPL37 | ribosomal protein L37 | 0.0435243 |
| RPL7A | ribosomal protein L7a | 0.0434845 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0433961 |
| MXD1 | MAX dimerization protein 1 | 0.0431494 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0428561 |
| RPL13A | ribosomal protein L13a | 0.0422315 |
| RPL37A | ribosomal protein L37a | 0.0421458 |
| USP53 | ubiquitin specific peptidase 53 | 0.0419939 |
| LAMA4 | laminin, alpha 4 | 0.0419796 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0407719 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0404375 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0404257 |
| VMP1 | vacuole membrane protein 1 | 0.0403603 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0403003 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0401009 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0400676 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0391088 |
| LMO7 | LIM domain 7 | 0.0380863 |
| FLNB | filamin B, beta | 0.0377842 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0375744 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0369417 |
| B2M | beta-2-microglobulin | 0.036877 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0367456 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0364697 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0364507 |
| UBC | ubiquitin C | 0.036416 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0360317 |
| RPL11 | ribosomal protein L11 | 0.0353303 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0352808 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0352628 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0350898 |
| RPL21 | ribosomal protein L21 | 0.0350382 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0349585 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0348165 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0346047 |
| H2AC6 | H2A clustered histone 6 | 0.0343724 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0343287 |
| RPL31 | ribosomal protein L31 | 0.0338558 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0337329 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0334865 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0333244 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.033239 |
| NCKAP1 | NCK-associated protein 1 | 0.0328602 |
| TFG | TRK-fused gene | 0.0327332 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.0325476 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0325071 |
| RPS3 | ribosomal protein S3 | 0.03196 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0315691 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0315546 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.030937 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0308523 |
| SETD5 | SET domain containing 5 | 0.0308173 |
| RPL32 | ribosomal protein L32 | 0.0307324 |
| HBS1L | HBS1-like translational GTPase | 0.0306442 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0300449 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | 0.0294086 |
| MYO5B | myosin VB | 0.0290835 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.029016 |
| CTBP2 | C-terminal binding protein 2 | 0.0289545 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.272515 |
| PTMA | prothymosin, alpha | -0.214835 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.139678 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.101161 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0855198 |
| RPS6 | ribosomal protein S6 | -0.0577603 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0549491 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.054805 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.054384 |
| RPL35A | ribosomal protein L35a | -0.0520568 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0464036 |
| KRT18 | keratin 18, type I | -0.0449815 |
| RPLP1 | ribosomal protein, large, P1 | -0.0427433 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0424069 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0411888 |
| EZR | ezrin | -0.0404282 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0400712 |
| LOC112694756 | uncharaterized LOC112694756 | -0.037795 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0370752 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0364431 |
| CD44 | CD44 molecule (Indian blood group) | -0.035859 |
| CD2AP | CD2-associated protein | -0.0349543 |
| RRBP1 | ribosome binding protein 1 | -0.0340842 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0339586 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0328526 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0325302 |
| AHNAK | AHNAK nucleoprotein | -0.0317588 |
| HMGB1 | high mobility group box 1 | -0.0314147 |
| DSPP | dentin sialophosphoprotein | -0.0313245 |
| CADPS | Ca++-dependent secretion activator | -0.0310801 |
| ERBIN | erbb2 interacting protein | -0.0309797 |
| PERP | PERP, TP53 apoptosis effector | -0.030817 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0306787 |
| RPL34 | ribosomal protein L34 | -0.0296648 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0295104 |
| ANXA1 | annexin A1 | -0.0294875 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.0291842 |
| CENPF | centromere protein F, 350/400kDa | -0.0281536 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0276914 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0269465 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0265361 |
| RPLP0 | ribosomal protein, large, P0 | -0.025747 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0255626 |
| NPSR1 | neuropeptide S receptor 1 | -0.0253322 |
| AGR2 | anterior gradient 2 | -0.025262 |
| POTEF | POTE ankyrin domain family, member F | -0.0249303 |
| DSG2 | desmoglein 2 | -0.0248639 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0248177 |
| GPHN | gephyrin | -0.0245826 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0244589 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0239908 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0239703 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0234493 |
| TMEM123 | transmembrane protein 123 | -0.0233824 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0231259 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0230858 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0229308 |
| NF1 | neurofibromin 1 | -0.022796 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0227016 |
| FNBP1L | formin binding protein 1-like | -0.0223148 |
| DYNC2I1 | dynein 2 intermediate chain 1 | -0.0219399 |
| EMP1 | epithelial membrane protein 1 | -0.0219143 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0216005 |
| S100A6 | S100 calcium binding protein A6 | -0.0215829 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0214433 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.021295 |
| GOLGB1 | golgin B1 | -0.0209223 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0208879 |
| ATP11A | ATPase, class VI, type 11A | -0.0208327 |
| YBX1 | Y box binding protein 1 | -0.0206519 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0205565 |
| BPTF | bromodomain PHD finger transcription factor | -0.0204872 |
| EHBP1 | EH domain binding protein 1 | -0.0203691 |
| CLOCK | clock circadian regulator | -0.0203457 |
| FBXO32 | F-box protein 32 | -0.0203131 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0202313 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0201556 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0201391 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0201281 |
| KRT19 | keratin 19, type I | -0.0199932 |
| CALB1 | calbindin 1, 28kDa | -0.0199369 |
| GOLGA4 | golgin A4 | -0.0196701 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0196503 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0196231 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0194537 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0193331 |
| SUCLG2 | succinate-CoA ligase, GDP-forming, beta subunit | -0.0192394 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0191152 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.0186904 |
| HDAC8 | histone deacetylase 8 | -0.0185942 |
| PHKB | phosphorylase kinase, beta | -0.0185778 |
| NSD3 | nuclear receptor binding SET domain protein 3 | -0.0185312 |
| WDR45B | WD repeat domain 45B | -0.0185092 |
| ANAPC5 | anaphase promoting complex subunit 5 | -0.0184045 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | -0.0181426 |
| MT2A | metallothionein 2A | -0.0181154 |
| BMP7 | bone morphogenetic protein 7 | -0.0180438 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0180093 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.018001 |
| RFX7 | regulatory factor X, 7 | -0.0179521 |
