| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.15341 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0985508 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0667824 |
| TXNRD1 | thioredoxin reductase 1 | 0.0666957 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0620658 |
| SPAG9 | sperm associated antigen 9 | 0.0619213 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0581027 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.054209 |
| PTMA | prothymosin, alpha | 0.053871 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0529001 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0517961 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0510739 |
| NUP58 | nucleoporin 58 | 0.0510544 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0501368 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0497088 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0489065 |
| RTN4 | reticulon 4 | 0.0428597 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0419301 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0408755 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0402974 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0400103 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0399903 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0399729 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0393415 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0391392 |
| EZR | ezrin | 0.0386998 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.038367 |
| RBM39 | RNA binding motif protein 39 | 0.0364316 |
| MATR3 | matrin 3 | 0.0361702 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0357487 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.035659 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0350197 |
| XPO1 | exportin 1 | 0.0346224 |
| NCKAP1 | NCK-associated protein 1 | 0.034575 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0345612 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0343867 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0342872 |
| ANXA1 | annexin A1 | 0.0341212 |
| CCNL1 | cyclin L1 | 0.0338658 |
| PGK1 | phosphoglycerate kinase 1 | 0.0338632 |
| YBX1 | Y box binding protein 1 | 0.033863 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0330579 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.032871 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0326113 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0317983 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0316984 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0311167 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0308366 |
| TMEM41B | transmembrane protein 41B | 0.0307999 |
| WDR43 | WD repeat domain 43 | 0.0307541 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0300351 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0298903 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0295355 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0294752 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0293698 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0293377 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0292009 |
| UBC | ubiquitin C | 0.028928 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0288642 |
| ZNF292 | zinc finger protein 292 | 0.028732 |
| ECT2 | epithelial cell transforming 2 | 0.0285208 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0282791 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0281058 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0277862 |
| RNF145 | ring finger protein 145 | 0.0274028 |
| OGA | O-GlcNAcase | 0.0273217 |
| WDR45B | WD repeat domain 45B | 0.0271853 |
| TOP1 | topoisomerase (DNA) I | 0.0271443 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0269343 |
| SETD5 | SET domain containing 5 | 0.0267795 |
| TENT2 | terminal nucleotidyltransferase 2 | 0.0266563 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0265211 |
| TFRC | transferrin receptor | 0.0265053 |
| GOLGA4 | golgin A4 | 0.0263549 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0260274 |
| YBX3 | Y box binding protein 3 | 0.0259198 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.025748 |
| FOXJ3 | forkhead box J3 | 0.0254596 |
| RLF | rearranged L-myc fusion | 0.0252655 |
| EREG | epiregulin | 0.0251337 |
| SEPTIN7 | septin 7 | 0.0250882 |
| YME1L1 | YME1-like 1 ATPase | 0.0249007 |
| TNPO1 | transportin 1 | 0.0243538 |
| ARRDC3 | arrestin domain containing 3 | 0.0243024 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0242865 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0240679 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0239891 |
| RHEB | Ras homolog enriched in brain | 0.0239846 |
| QKI | QKI, KH domain containing, RNA binding | 0.0238535 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0236974 |
| JMJD1C | jumonji domain containing 1C | 0.023666 |
| TFG | TRK-fused gene | 0.0236377 |
| AHCTF1 | AT hook containing transcription factor 1 | 0.0236081 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0234807 |
| OLA1 | Obg-like ATPase 1 | 0.0234736 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0234635 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0232973 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0232571 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0232507 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0231686 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.168618 |
| TP63 | tumor protein p63 | -0.148853 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.125294 |
| CADM2 | cell adhesion molecule 2 | -0.104803 |
| CD44 | CD44 molecule (Indian blood group) | -0.097713 |
| DST | dystonin | -0.0919922 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0786192 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0685614 |
| RUNX1 | runt-related transcription factor 1 | -0.0667562 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0651042 |
| EHBP1 | EH domain binding protein 1 | -0.0630175 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0616259 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0597212 |
| TNS3 | tensin 3 | -0.0596808 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0535883 |
| HDAC9 | histone deacetylase 9 | -0.0519014 |
| PRELID2 | PRELI domain containing 2 | -0.0516469 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0488193 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0460524 |
| RIGI | RNA sensor RIG-I | -0.0438784 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.04377 |
| PDE10A | phosphodiesterase 10A | -0.0430997 |
| EPHA4 | EPH receptor A4 | -0.0427099 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0399428 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0398545 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0392837 |
| EFNA5 | ephrin-A5 | -0.038288 |
| SP100 | SP100 nuclear antigen | -0.0377731 |
| VIM | vimentin | -0.037219 |
| RNF213 | ring finger protein 213 | -0.0354844 |
| RAD51B | RAD51 paralog B | -0.0352649 |
| EGFR | epidermal growth factor receptor | -0.0347367 |
| EGR1 | early growth response 1 | -0.0341577 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.033199 |
| TSC22D1 | TSC22 domain family, member 1 | -0.0331603 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0326479 |
| EXOC4 | exocyst complex component 4 | -0.0324772 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0312904 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0309943 |
| CMIP | c-Maf inducing protein | -0.0304553 |
| PODXL | podocalyxin-like | -0.0302082 |
| WDR27 | WD repeat domain 27 | -0.0296008 |
| INTS6 | integrator complex subunit 6 | -0.029409 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0288261 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0277574 |
| PLSCR1 | phospholipid scramblase 1 | -0.0270965 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0270778 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0270772 |
| SMYD3 | SET and MYND domain containing 3 | -0.0269617 |
| NEK10 | NIMA-related kinase 10 | -0.0266037 |
| DENND1A | DENN/MADD domain containing 1A | -0.0265382 |
| DPH6 | diphthamine biosynthesis 6 | -0.0263469 |
| DNER | delta/notch-like EGF repeat containing | -0.0263134 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0260684 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0251965 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0248986 |
| VCL | vinculin | -0.0247126 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0244597 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0243445 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0243401 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0243076 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0239722 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0237678 |
| CCDC91 | coiled-coil domain containing 91 | -0.0230871 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0229966 |
| AEBP2 | AE binding protein 2 | -0.0222856 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0213962 |
| STK17A | serine/threonine kinase 17a | -0.0213548 |
| SUMF1 | sulfatase modifying factor 1 | -0.0207983 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0207895 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.020756 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0207394 |
| LOXL2 | lysyl oxidase-like 2 | -0.0207268 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0205048 |
| PMP22 | peripheral myelin protein 22 | -0.0204325 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0201859 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0201624 |
| DOCK1 | dedicator of cytokinesis 1 | -0.0197874 |
| TBCA | tubulin folding cofactor A | -0.0197362 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0195463 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.01945 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.0192126 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0191684 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0188905 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.0188635 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0187636 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0183207 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0183057 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0180692 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0180406 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0180194 |
| HDAC8 | histone deacetylase 8 | -0.0178099 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0177712 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0176293 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0171292 |
| SCAPER | S-phase cyclin A-associated protein in the ER | -0.0170908 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0169488 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | -0.0168726 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0168068 |
| TGM2 | transglutaminase 2 | -0.0164167 |
