Canagliflozin_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.0797171
ANKRD10 ankyrin repeat domain 10 0.0753488
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0619924
SMAD3 SMAD family member 3 0.0578439
FNDC3B fibronectin type III domain containing 3B 0.0574071
RPL37A ribosomal protein L37a 0.0539777
RPS3 ribosomal protein S3 0.0491544
TPT1 tumor protein, translationally-controlled 1 0.0486356
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0476046
CEMIP cell migration inducing protein, hyaluronan binding 0.0467208
PTPRM protein tyrosine phosphatase, receptor type, M 0.0450331
MCL1 myeloid cell leukemia 1 0.0443936
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0431684
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.042181
RPS25 ribosomal protein S25 0.0413262
PDE4D phosphodiesterase 4D, cAMP-specific 0.0405867
RPS12 ribosomal protein S12 0.0389392
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0381609
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0380681
RPL35A ribosomal protein L35a 0.036475
SLC38A1 solute carrier family 38, member 1 0.0364696
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0363072
B2M beta-2-microglobulin 0.0353105
PDE8A phosphodiesterase 8A 0.0343499
RPL11 ribosomal protein L11 0.0325727
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0318916
GRAMD1B GRAM domain containing 1B 0.0312877
SEC61G Sec61 gamma subunit 0.0310869
DENND4A DENN/MADD domain containing 4A 0.0308205
RPS29 ribosomal protein S29 0.0305694
MACF1 microtubule-actin crosslinking factor 1 0.0302254
NUP58 nucleoporin 58 0.0301541
RPS27A ribosomal protein S27a 0.029851
NAMPT nicotinamide phosphoribosyltransferase 0.0298088
RPS6 ribosomal protein S6 0.0297328
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0294736
AKAP12 A kinase (PRKA) anchor protein 12 0.0293795
NRIP1 nuclear receptor interacting protein 1 0.0291292
RPL37 ribosomal protein L37 0.0290255
ENO1 enolase 1, (alpha) 0.0290211
RPS17 ribosomal protein S17 0.0283673
MYO5B myosin VB 0.0278205
PTMA prothymosin, alpha 0.0275847
GPC6 glypican 6 0.0274079
HOOK2 hook microtubule-tethering protein 2 0.0271953
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.026848
RAD51B RAD51 paralog B 0.0268397
THSD4 thrombospondin, type I, domain containing 4 0.0266105
KDM6A lysine (K)-specific demethylase 6A 0.0265664
UVRAG UV radiation resistance associated 0.0265213
ATP13A3 ATPase type 13A3 0.0263247
RPS24 ribosomal protein S24 0.0261773
ZNF292 zinc finger protein 292 0.0261512
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0259975
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0255734
RPS19 ribosomal protein S19 0.0254894
PGK1 phosphoglycerate kinase 1 0.0247766
WSB1 WD repeat and SOCS box containing 1 0.0246525
RPL36 ribosomal protein L36 0.0245414
RPLP2 ribosomal protein, large, P2 0.024155
RPL31 ribosomal protein L31 0.023757
RNF145 ring finger protein 145 0.0235401
DOCK4 dedicator of cytokinesis 4 0.02299
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0229536
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0229113
RPL23 ribosomal protein L23 0.0228274
RPS23 ribosomal protein S23 0.0227406
LRP1B low density lipoprotein receptor-related protein 1B 0.0227381
RPL7 ribosomal protein L7 0.0227318
TOP1 topoisomerase (DNA) I 0.0225761
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0223173
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0222278
RPS13 ribosomal protein S13 0.0220767
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0219544
MYH9 myosin, heavy chain 9, non-muscle 0.0219182
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0217835
RPS8 ribosomal protein S8 0.021545
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.021507
RPL9 ribosomal protein L9 0.0214813
RPL36A ribosomal protein L36a 0.0212359
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0211986
RPL19 ribosomal protein L19 0.0209606
ARMH4 armadillo like helical domain containing 4 0.0208186
RPS27 ribosomal protein S27 0.0206773
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0206748
WAC WW domain containing adaptor with coiled-coil 0.0206542
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0206476
NOP58 NOP58 ribonucleoprotein 0.0205204
NAP1L1 nucleosome assembly protein 1-like 1 0.0202874
ADGRA3 adhesion G protein-coupled receptor A3 0.02027
PM20D1 peptidase M20 domain containing 1 0.020222
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0201725
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0201696
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0201117
RPLP1 ribosomal protein, large, P1 0.0197835
SLK STE20-like kinase 0.0197336
CCNL1 cyclin L1 0.0195175
ARHGAP26 Rho GTPase activating protein 26 0.0194711
RPL7A ribosomal protein L7a 0.0192468
RPL34 ribosomal protein L34 0.0191745

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.240493
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.224214
TXNRD1 thioredoxin reductase 1 -0.170344
FTH1 ferritin, heavy polypeptide 1 -0.109208
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.10031
CES1 carboxylesterase 1 -0.0941266
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.088885
ASPH aspartate beta-hydroxylase -0.0611333
MKI67 marker of proliferation Ki-67 -0.0603035
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0588624
PATJ PATJ crumbs cell polarity complex component -0.0552391
BRWD1 bromodomain and WD repeat domain containing 1 -0.0542017
GCLC glutamate-cysteine ligase, catalytic subunit -0.0524447
AGO2 argonaute RISC catalytic component 2 -0.0467963
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0462869
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0459915
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0439775
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0435215
LOC112694756 uncharaterized LOC112694756 -0.0433573
PKM pyruvate kinase, muscle -0.0432519
ZC3H11A zinc finger CCCH-type containing 11A -0.0428432
DOCK5 dedicator of cytokinesis 5 -0.0416244
SCEL sciellin -0.0402163
OSMR oncostatin M receptor -0.0402081
KMT2A lysine (K)-specific methyltransferase 2A -0.0397658
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0390617
BIRC6 baculoviral IAP repeat containing 6 -0.0389661
TES testin LIM domain protein -0.0382873
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0382515
MGST1 microsomal glutathione S-transferase 1 -0.0370229
NBEAL1 neurobeachin-like 1 -0.0367669
SLC38A2 solute carrier family 38, member 2 -0.0366759
GOLGB1 golgin B1 -0.0364623
CAV1 caveolin 1, caveolae protein, 22kDa -0.0360177
NGLY1 N-glycanase 1 -0.0359811
SOS1 son of sevenless homolog 1 (Drosophila) -0.0356888
TAOK1 TAO kinase 1 -0.0352667
LAMA4 laminin, alpha 4 -0.0348567
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0346306
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0341844
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0336132
TMEM165 transmembrane protein 165 -0.0334365
CANX calnexin -0.0333527
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0333259
TMCO3 transmembrane and coiled-coil domains 3 -0.0327611
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0327188
TBC1D22A TBC1 domain family, member 22A -0.0323909
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0317014
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0312558
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0312391
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0311119
HDLBP high density lipoprotein binding protein -0.0310663
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0308504
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0306766
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0304787
STC1 stanniocalcin 1 -0.029442
ANKRD17 ankyrin repeat domain 17 -0.0294186
MYO1B myosin IB -0.0289452
NABP1 nucleic acid binding protein 1 -0.028911
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0273663
MBD5 methyl-CpG binding domain protein 5 -0.027346
HYOU1 hypoxia up-regulated 1 -0.0272918
MORF4L2 mortality factor 4 like 2 -0.026288
SCLT1 sodium channel and clathrin linker 1 -0.0259953
EXOC6B exocyst complex component 6B -0.02552
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0254084
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0252526
ZNF609 zinc finger protein 609 -0.0252189
LDHA lactate dehydrogenase A -0.0251796
SON SON DNA binding protein -0.0245261
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0243568
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0243387
BPTF bromodomain PHD finger transcription factor -0.0242649
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0241437
MIDEAS mitotic deacetylase associated SANT domain protein -0.0241407
BRWD3 bromodomain and WD repeat domain containing 3 -0.0240809
FRYL FRY-like -0.0240331
PDIA3 protein disulfide isomerase family A, member 3 -0.0237912
AKR1C1 aldo-keto reductase family 1, member C1 -0.0231711
MAML3 mastermind-like 3 (Drosophila) -0.0228447
CCNI cyclin I -0.0226711
MIB1 mindbomb E3 ubiquitin protein ligase 1 -0.0224569
LPCAT2 lysophosphatidylcholine acyltransferase 2 -0.0217884
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0217798
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.021639
FRY furry homolog (Drosophila) -0.0216313
OGA O-GlcNAcase -0.0213718
TSC22D2 TSC22 domain family, member 2 -0.0213492
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0212867
LRP12 low density lipoprotein receptor-related protein 12 -0.0212036
CENPF centromere protein F, 350/400kDa -0.0210231
PER2 period circadian clock 2 -0.0209193
MRPS6 mitochondrial ribosomal protein S6 -0.0205398
RIOK3 RIO kinase 3 -0.0205348
ABLIM1 actin binding LIM protein 1 -0.020509
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0202405
ADAM32 ADAM metallopeptidase domain 32 -0.0201741
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0201635
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0201436
RUNX1 runt-related transcription factor 1 -0.0200511