| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.15132 |
| GRB10 | growth factor receptor-bound protein 10 | 0.148649 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.136029 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.119317 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.112238 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.111754 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.091826 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0913886 |
| PCBP2 | poly(rC) binding protein 2 | 0.0896855 |
| ATP13A3 | ATPase type 13A3 | 0.0832342 |
| UBC | ubiquitin C | 0.0798826 |
| VIM | vimentin | 0.0772745 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0726019 |
| FN1 | fibronectin 1 | 0.0707067 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0647285 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0594868 |
| MEF2A | myocyte enhancer factor 2A | 0.053581 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0530484 |
| FAM13A | family with sequence similarity 13, member A | 0.0519927 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0508875 |
| LDHA | lactate dehydrogenase A | 0.0507745 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0491385 |
| FAM20C | family with sequence similarity 20, member C | 0.0456877 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0449831 |
| PID1 | phosphotyrosine interaction domain containing 1 | 0.0437249 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.043548 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0423991 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0420515 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0412082 |
| FLNB | filamin B, beta | 0.0409009 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0403546 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0395194 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0394357 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0384692 |
| CALR | calreticulin | 0.0380898 |
| ADD3 | adducin 3 (gamma) | 0.0372051 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0371021 |
| NGLY1 | N-glycanase 1 | 0.0367151 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0365574 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0364756 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0362864 |
| LOX | lysyl oxidase | 0.0360514 |
| DNER | delta/notch-like EGF repeat containing | 0.0357988 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0351244 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0346819 |
| OXSR1 | oxidative stress responsive 1 | 0.0346422 |
| MCL1 | myeloid cell leukemia 1 | 0.0346196 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0339381 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0338231 |
| RUNX2 | runt-related transcription factor 2 | 0.0332718 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0325461 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0323941 |
| CD109 | CD109 molecule | 0.032219 |
| USP3 | ubiquitin specific peptidase 3 | 0.0321814 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0319094 |
| COPA | coatomer protein complex, subunit alpha | 0.0318122 |
| AHNAK | AHNAK nucleoprotein | 0.0315504 |
| OGA | O-GlcNAcase | 0.0314212 |
| RIOK3 | RIO kinase 3 | 0.0308405 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0305662 |
| VMP1 | vacuole membrane protein 1 | 0.0305393 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.029909 |
| SETD5 | SET domain containing 5 | 0.0296866 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0294959 |
| PFKP | phosphofructokinase, platelet | 0.0290184 |
| SPAG9 | sperm associated antigen 9 | 0.0289555 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0286398 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0286309 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0285896 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0285381 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0285276 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0284145 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0283382 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0282569 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0281442 |
| HELZ | helicase with zinc finger | 0.0280207 |
| RAI1 | retinoic acid induced 1 | 0.0278556 |
| YME1L1 | YME1-like 1 ATPase | 0.0277993 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0274051 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0273764 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0273132 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0271423 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0269167 |
| SIK3 | SIK family kinase 3 | 0.0268659 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0265779 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0264789 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.026178 |
| MARS1 | methionyl-tRNA synthetase 1 | 0.0258257 |
| COG5 | component of oligomeric golgi complex 5 | 0.0257161 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0257064 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0256837 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0256079 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0255949 |
| AAK1 | AP2 associated kinase 1 | 0.0254915 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0254588 |
| PKM | pyruvate kinase, muscle | 0.0253199 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0252934 |
| ARF4 | ADP-ribosylation factor 4 | 0.0252372 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.024949 |
| MYO1B | myosin IB | 0.0248386 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.127138 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.118782 |
| EFNA5 | ephrin-A5 | -0.100713 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0893473 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0807066 |
| CD44 | CD44 molecule (Indian blood group) | -0.0758509 |
| RPS2 | ribosomal protein S2 | -0.074066 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0718027 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0686468 |
| NDRG1 | N-myc downstream regulated 1 | -0.059639 |
| SMAD3 | SMAD family member 3 | -0.0576336 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0571934 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0564364 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0561344 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0533543 |
| CDCP1 | CUB domain containing protein 1 | -0.0489174 |
| RPS6 | ribosomal protein S6 | -0.0474124 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0429185 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0424957 |
| OSMR | oncostatin M receptor | -0.0418978 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0416849 |
| RAD51B | RAD51 paralog B | -0.0398649 |
| RPS19 | ribosomal protein S19 | -0.0390802 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0386968 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0371953 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0370422 |
| RPL36 | ribosomal protein L36 | -0.0365045 |
| RPL11 | ribosomal protein L11 | -0.0364809 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0347695 |
| RPLP1 | ribosomal protein, large, P1 | -0.034187 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0341727 |
| RPL38 | ribosomal protein L38 | -0.033791 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0337013 |
| RPS21 | ribosomal protein S21 | -0.0336165 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0335983 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0333056 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0330333 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0318389 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0317672 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0315331 |
| RPL32 | ribosomal protein L32 | -0.0312138 |
| TGM2 | transglutaminase 2 | -0.0305264 |
| JMJD1C | jumonji domain containing 1C | -0.0297317 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0292383 |
| SLFN5 | schlafen family member 5 | -0.0291486 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0289354 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0289299 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0287701 |
| FTL | ferritin, light polypeptide | -0.0286874 |
| DST | dystonin | -0.0283588 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0273449 |
| RPL31 | ribosomal protein L31 | -0.027339 |
| VEGFA | vascular endothelial growth factor A | -0.0272609 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0271843 |
| CEP350 | centrosomal protein 350kDa | -0.0271217 |
| COPZ1 | coatomer protein complex, subunit zeta 1 | -0.0270103 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0267362 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0266165 |
| BPTF | bromodomain PHD finger transcription factor | -0.0265755 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0262856 |
| DSG2 | desmoglein 2 | -0.0256855 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0255392 |
| RPS29 | ribosomal protein S29 | -0.0252532 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0252002 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0251017 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0250567 |
| GPHN | gephyrin | -0.024904 |
| RPS12 | ribosomal protein S12 | -0.0244793 |
| YBX3 | Y box binding protein 3 | -0.0244271 |
| RPL28 | ribosomal protein L28 | -0.0241846 |
| ECE1 | endothelin converting enzyme 1 | -0.0241714 |
| KDSR | 3-ketodihydrosphingosine reductase | -0.0241518 |
| ATP5MC2 | ATP synthase membrane subunit c locus 2 | -0.0241302 |
| FNBP1 | formin binding protein 1 | -0.0241014 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0237216 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0236436 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0233646 |
| NRG1 | neuregulin 1 | -0.0232386 |
| UBXN4 | UBX domain protein 4 | -0.0231027 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0229687 |
| HLA-B | major histocompatibility complex, class I, B | -0.0229265 |
| GOLGB1 | golgin B1 | -0.0227868 |
| CANX | calnexin | -0.022677 |
| RPL9 | ribosomal protein L9 | -0.0225518 |
| STC1 | stanniocalcin 1 | -0.0225067 |
| RPS8 | ribosomal protein S8 | -0.0224852 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0224167 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | -0.0219656 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0217572 |
| RPS13 | ribosomal protein S13 | -0.0217308 |
| KIAA1217 | KIAA1217 | -0.0216928 |
| WDPCP | WD repeat containing planar cell polarity effector | -0.021682 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | -0.0216813 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0216069 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0215532 |
| RPLP2 | ribosomal protein, large, P2 | -0.0212913 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0211729 |
| FNIP1 | folliculin interacting protein 1 | -0.0209007 |
| ZNF638 | zinc finger protein 638 | -0.0208995 |
| SH3GLB1 | SH3-domain GRB2-like endophilin B1 | -0.0208878 |
