| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0573998 |
| TXNRD1 | thioredoxin reductase 1 | 0.0488339 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0417856 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0366857 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0363942 |
| RPL19 | ribosomal protein L19 | 0.0306805 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0297396 |
| TMSB10 | thymosin beta 10 | 0.0281069 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0266798 |
| PTMA | prothymosin, alpha | 0.0264855 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0255407 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0246748 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0232048 |
| RPL23 | ribosomal protein L23 | 0.0231089 |
| ASPH | aspartate beta-hydroxylase | 0.0230244 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0222133 |
| RPL7 | ribosomal protein L7 | 0.0215193 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0213527 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0208946 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0208563 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0200575 |
| RPS29 | ribosomal protein S29 | 0.0198218 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0196706 |
| GRAMD1B | GRAM domain containing 1B | 0.0194472 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0189439 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0188924 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0187062 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0185549 |
| RPL36 | ribosomal protein L36 | 0.0179519 |
| RPS19 | ribosomal protein S19 | 0.0161604 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0161561 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.016038 |
| RPS12 | ribosomal protein S12 | 0.0152644 |
| RPL18 | ribosomal protein L18 | 0.0150885 |
| RPL8 | ribosomal protein L8 | 0.0148538 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0147741 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.014456 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0143277 |
| RPL3 | ribosomal protein L3 | 0.0143054 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0142823 |
| RPL36A | ribosomal protein L36a | 0.014239 |
| RPS3 | ribosomal protein S3 | 0.0142108 |
| SERF2 | small EDRK-rich factor 2 | 0.0141883 |
| KLF6 | Kruppel-like factor 6 | 0.0141819 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0141255 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0139045 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0137112 |
| RPS21 | ribosomal protein S21 | 0.0134827 |
| RPS25 | ribosomal protein S25 | 0.0131403 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0128709 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0128469 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0127923 |
| RPS7 | ribosomal protein S7 | 0.0127584 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0127244 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0127002 |
| RPS5 | ribosomal protein S5 | 0.0126581 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0124525 |
| SMAD3 | SMAD family member 3 | 0.012364 |
| SRSF1 | serine/arginine-rich splicing factor 1 | 0.0123551 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 0.0120615 |
| XPO1 | exportin 1 | 0.011783 |
| FAT1 | FAT atypical cadherin 1 | 0.011741 |
| ROMO1 | reactive oxygen species modulator 1 | 0.0116217 |
| CALR | calreticulin | 0.011578 |
| RPS27A | ribosomal protein S27a | 0.0114564 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0113898 |
| RPS11 | ribosomal protein S11 | 0.0113229 |
| THBS1 | thrombospondin 1 | 0.0112032 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0111812 |
| MKI67 | marker of proliferation Ki-67 | 0.0110696 |
| DST | dystonin | 0.011023 |
| UBC | ubiquitin C | 0.0109047 |
| APP | amyloid beta (A4) precursor protein | 0.0108259 |
| UPP1 | uridine phosphorylase 1 | 0.0108195 |
| CAVIN1 | caveolae associated protein 1 | 0.0107637 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0107581 |
| RPL32 | ribosomal protein L32 | 0.0107033 |
| RPL7A | ribosomal protein L7a | 0.010654 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0104677 |
| SFTPA2 | surfactant protein A2 | 0.0104084 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0103041 |
| BICC1 | BicC family RNA binding protein 1 | 0.010237 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0101692 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0101556 |
| CANX | calnexin | 0.00995599 |
| KARS1 | lysyl-tRNA synthetase 1 | 0.00991603 |
| RPL13A | ribosomal protein L13a | 0.00972408 |
| RPS15 | ribosomal protein S15 | 0.00971984 |
| GOLT1B | golgi transport 1B | 0.00955463 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.00954354 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.00952177 |
| FBL | fibrillarin | 0.00948404 |
| RPS10 | ribosomal protein S10 | 0.00942357 |
| RPS16 | ribosomal protein S16 | 0.00939962 |
| RPL4 | ribosomal protein L4 | 0.00936889 |
| NOB1 | NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) | 0.00936011 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.00932302 |
| FAU | Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed | 0.00932244 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 0.00925609 |
| HYOU1 | hypoxia up-regulated 1 | 0.00924025 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.129336 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0738641 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0654384 |
| IGF2 | insulin-like growth factor 2 | -0.0589589 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0498545 |
| POTEF | POTE ankyrin domain family, member F | -0.0474267 |
| PARD3 | par-3 family cell polarity regulator | -0.0433281 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.040315 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0386206 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0380102 |
| HLA-B | major histocompatibility complex, class I, B | -0.0374901 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0324623 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0317607 |
| RBM25 | RNA binding motif protein 25 | -0.0303207 |
| VIM | vimentin | -0.0295564 |
| RPL35A | ribosomal protein L35a | -0.0282259 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0279118 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0278094 |
| GLG1 | golgi glycoprotein 1 | -0.0276532 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0272455 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0258974 |
| NDRG1 | N-myc downstream regulated 1 | -0.0248892 |
| FBXO11 | F-box protein 11 | -0.0244929 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0243572 |
| RPLP1 | ribosomal protein, large, P1 | -0.0236096 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0233704 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0223268 |
| HLA-A | major histocompatibility complex, class I, A | -0.0216944 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0203634 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0203412 |
| COPA | coatomer protein complex, subunit alpha | -0.0198026 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.019696 |
| CMIP | c-Maf inducing protein | -0.0195316 |
| NF1 | neurofibromin 1 | -0.0195016 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0193596 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0193316 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0191068 |
| PYGL | phosphorylase, glycogen, liver | -0.0186822 |
| GGNBP2 | gametogenetin binding protein 2 | -0.0186203 |
| RAD51B | RAD51 paralog B | -0.018614 |
| ZNF207 | zinc finger protein 207 | -0.0186038 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0185928 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0184473 |
| IL6 | interleukin 6 | -0.0177242 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0173161 |
| MATR3 | matrin 3 | -0.0171759 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0170001 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0169715 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0167875 |
| PTK2 | protein tyrosine kinase 2 | -0.0167808 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0166506 |
| RNF145 | ring finger protein 145 | -0.0163716 |
| CD44 | CD44 molecule (Indian blood group) | -0.0162979 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0159106 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0158905 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0157849 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0156489 |
| SNX14 | sorting nexin 14 | -0.0155436 |
| ACTG1 | actin gamma 1 | -0.015481 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0153292 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0151375 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0148955 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0146855 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0145736 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | -0.0145284 |
| NLK | nemo-like kinase | -0.0145107 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.014252 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0142201 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0141802 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0141752 |
| EGR1 | early growth response 1 | -0.0141677 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0141083 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0140582 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | -0.0140183 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0138384 |
| ANGPTL4 | angiopoietin-like 4 | -0.0138206 |
| SVIL | supervillin | -0.0137685 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.013655 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0134296 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0133342 |
| SEPTIN7 | septin 7 | -0.0133273 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0133208 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0133123 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0131804 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0131178 |
| GNAS | GNAS complex locus | -0.0130216 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | -0.012988 |
| ARMH4 | armadillo like helical domain containing 4 | -0.0129855 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0129654 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0129435 |
| ZNF451 | zinc finger protein 451 | -0.012831 |
| S100A6 | S100 calcium binding protein A6 | -0.0127727 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | -0.0127669 |
| COG5 | component of oligomeric golgi complex 5 | -0.0127399 |
| GOLGA4 | golgin A4 | -0.012694 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0126456 |
| HLA-E | major histocompatibility complex, class I, E | -0.0125602 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0125587 |
| EGFR | epidermal growth factor receptor | -0.0125293 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0125261 |
