| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.136483 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.119391 |
| GOLGA4 | golgin A4 | 0.0795033 |
| PTK2 | protein tyrosine kinase 2 | 0.0763752 |
| SRPK2 | SRSF protein kinase 2 | 0.0760657 |
| PTMA | prothymosin, alpha | 0.0744634 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | 0.0724265 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0713253 |
| THOC2 | THO complex 2 | 0.0635158 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.063253 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0615255 |
| NAV2 | neuron navigator 2 | 0.060097 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0592339 |
| APP | amyloid beta (A4) precursor protein | 0.0558234 |
| RPL19 | ribosomal protein L19 | 0.0549549 |
| CCNL1 | cyclin L1 | 0.0536663 |
| XPO1 | exportin 1 | 0.0528281 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.051204 |
| NOP58 | NOP58 ribonucleoprotein | 0.0496728 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.048647 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0483299 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0477422 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0470179 |
| RPL37A | ribosomal protein L37a | 0.0456943 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0453431 |
| NUP58 | nucleoporin 58 | 0.0449618 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0448787 |
| TOP1 | topoisomerase (DNA) I | 0.0439611 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0428383 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0427216 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | 0.0423556 |
| MED13 | mediator complex subunit 13 | 0.0420166 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0394586 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0393135 |
| NDRG1 | N-myc downstream regulated 1 | 0.039298 |
| RNF149 | ring finger protein 149 | 0.039178 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0389714 |
| RPL11 | ribosomal protein L11 | 0.0386361 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0383271 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0377036 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0371752 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0367342 |
| CALU | calumenin | 0.0362861 |
| RPS3 | ribosomal protein S3 | 0.036148 |
| ANXA2 | annexin A2 | 0.0347812 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0344262 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0342265 |
| RPS16 | ribosomal protein S16 | 0.0339383 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0334061 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0332616 |
| U2SURP | U2 snRNP-associated SURP domain containing | 0.031884 |
| S100A6 | S100 calcium binding protein A6 | 0.0316436 |
| STAU1 | staufen double-stranded RNA binding protein 1 | 0.0313529 |
| KCTD9 | potassium channel tetramerization domain containing 9 | 0.0313269 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0312249 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0306782 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0305421 |
| B2M | beta-2-microglobulin | 0.0304546 |
| DBF4 | DBF4 zinc finger | 0.0302509 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.030242 |
| GLCCI1 | glucocorticoid induced 1 | 0.0296873 |
| ACTN4 | actinin, alpha 4 | 0.0295333 |
| TMEM165 | transmembrane protein 165 | 0.0295062 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0294086 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0290103 |
| AK1 | adenylate kinase 1 | 0.0289392 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0289169 |
| SMYD3 | SET and MYND domain containing 3 | 0.0286405 |
| OGA | O-GlcNAcase | 0.0282139 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.028135 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0271948 |
| FTL | ferritin, light polypeptide | 0.027159 |
| PDE8A | phosphodiesterase 8A | 0.0262941 |
| OSBPL3 | oxysterol binding protein-like 3 | 0.0260361 |
| RPS6 | ribosomal protein S6 | 0.0257729 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0253137 |
| AHNAK | AHNAK nucleoprotein | 0.0250676 |
| KRT8 | keratin 8, type II | 0.0248215 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.024565 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0244621 |
| RPS21 | ribosomal protein S21 | 0.0240301 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0240267 |
| PRKCA | protein kinase C, alpha | 0.0238422 |
| SMC3 | structural maintenance of chromosomes 3 | 0.0237104 |
| ECT2 | epithelial cell transforming 2 | 0.0234327 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0226723 |
| NPTN | neuroplastin | 0.0223486 |
| ACVR1 | activin A receptor, type I | 0.0223384 |
| PTEN | phosphatase and tensin homolog | 0.0215904 |
| IER3 | immediate early response 3 | 0.0215161 |
| HLA-B | major histocompatibility complex, class I, B | 0.0211357 |
| DICER1 | dicer 1, ribonuclease type III | 0.0206802 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0206564 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.02058 |
| RPS29 | ribosomal protein S29 | 0.0205334 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0205246 |
| RORA | RAR-related orphan receptor A | 0.0205113 |
| SLC38A1 | solute carrier family 38, member 1 | 0.01982 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0196613 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0191426 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.229259 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0969467 |
| S100A9 | S100 calcium binding protein A9 | -0.0963643 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0935839 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0838981 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0808766 |
| KRT17 | keratin 17, type I | -0.079113 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0760891 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0758585 |
| ABHD17C | abhydrolase domain containing 17C | -0.0744214 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.074055 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0653859 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0638835 |
| MYO1E | myosin IE | -0.0630858 |
| VCL | vinculin | -0.061658 |
| KYNU | kynureninase | -0.0612636 |
| THBS1 | thrombospondin 1 | -0.060548 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0593657 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0582389 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.056896 |
| MCL1 | myeloid cell leukemia 1 | -0.0559588 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0554989 |
| EGR1 | early growth response 1 | -0.0543012 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0540707 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | -0.0525031 |
| LMO7 | LIM domain 7 | -0.0513814 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0506301 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0500342 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0500257 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0487488 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0486959 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0483934 |
| CREBBP | CREB binding protein | -0.0480859 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | -0.0467813 |
| SIK3 | SIK family kinase 3 | -0.0466118 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0460534 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0460531 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.045188 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0450714 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0448663 |
| GOLGB1 | golgin B1 | -0.0440814 |
| GNAS | GNAS complex locus | -0.0431949 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0409621 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0406346 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0405093 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0387724 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0376175 |
| RPL37 | ribosomal protein L37 | -0.0373649 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.036744 |
| TJP1 | tight junction protein 1 | -0.0363599 |
| ATXN1 | ataxin 1 | -0.036342 |
| FRMD5 | FERM domain containing 5 | -0.0351516 |
| PAPOLA | poly(A) polymerase alpha | -0.0348938 |
| FN1 | fibronectin 1 | -0.034566 |
| FLNB | filamin B, beta | -0.0338449 |
| GPC6 | glypican 6 | -0.0321132 |
| STK17A | serine/threonine kinase 17a | -0.0314773 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.031472 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0312855 |
| NRG1 | neuregulin 1 | -0.0312022 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0310175 |
| AFF4 | AF4/FMR2 family, member 4 | -0.03081 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0306898 |
| EFNA5 | ephrin-A5 | -0.0301693 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0299447 |
| PGK1 | phosphoglycerate kinase 1 | -0.0298351 |
| RAI14 | retinoic acid induced 14 | -0.0294557 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.028358 |
| FAT1 | FAT atypical cadherin 1 | -0.0282206 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0280263 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0278213 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0276731 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0275213 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0267809 |
| PDE10A | phosphodiesterase 10A | -0.0266851 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0266349 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0252013 |
| RNF145 | ring finger protein 145 | -0.0245506 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0244683 |
| MED13L | mediator complex subunit 13-like | -0.0243252 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0236323 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.02274 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0225638 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0223745 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.021723 |
| ZNF292 | zinc finger protein 292 | -0.0217118 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0214925 |
| RAB10 | RAB10, member RAS oncogene family | -0.0214765 |
| CDCP1 | CUB domain containing protein 1 | -0.0213151 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0210932 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0210334 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0202281 |
| DST | dystonin | -0.0194673 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.019444 |
| EGFR | epidermal growth factor receptor | -0.0190172 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.018863 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0187409 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0182556 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0181647 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0179403 |
