Canagliflozin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.117602
ERRFI1 ERBB receptor feedback inhibitor 1 0.0855041
MCL1 myeloid cell leukemia 1 0.0672798
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0434606
MACF1 microtubule-actin crosslinking factor 1 0.0418576
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0414627
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0388022
PTK2 protein tyrosine kinase 2 0.0380014
GRAMD1B GRAM domain containing 1B 0.0355898
TPM3 tropomyosin 3 0.0334411
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0325073
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0283411
THSD4 thrombospondin, type I, domain containing 4 0.0281582
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0275089
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0274029
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0273483
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0271547
RAD51B RAD51 paralog B 0.0270357
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0268464
FMNL2 formin-like 2 0.0266937
USP34 ubiquitin specific peptidase 34 0.0259461
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0257819
PDE4D phosphodiesterase 4D, cAMP-specific 0.0255351
CEP192 centrosomal protein 192kDa 0.0250054
JMJD1C jumonji domain containing 1C 0.0249889
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0248261
MKI67 marker of proliferation Ki-67 0.0247545
SETD5 SET domain containing 5 0.0245562
ZCCHC7 zinc finger, CCHC domain containing 7 0.0244687
CDK17 cyclin-dependent kinase 17 0.0243956
WDR43 WD repeat domain 43 0.0239949
FAM168A family with sequence similarity 168, member A 0.023847
ZFAND3 zinc finger, AN1-type domain 3 0.0237629
MYH9 myosin, heavy chain 9, non-muscle 0.0234214
UBC ubiquitin C 0.0230836
ANO6 anoctamin 6 0.0229077
YAP1 Yes-associated protein 1 0.0224398
PYGL phosphorylase, glycogen, liver 0.0224164
FAF1 Fas (TNFRSF6) associated factor 1 0.0224158
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0222964
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0221496
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0219338
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0216197
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0215625
AFF3 AF4/FMR2 family, member 3 0.0215285
EXT1 exostosin glycosyltransferase 1 0.0214634
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0212736
CSDE1 cold shock domain containing E1, RNA-binding 0.0212656
PRELID2 PRELI domain containing 2 0.021146
PUM1 pumilio RNA-binding family member 1 0.0211328
RICTOR RPTOR independent companion of MTOR, complex 2 0.0210765
DOCK5 dedicator of cytokinesis 5 0.0209325
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0208956
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0206099
ATP13A3 ATPase type 13A3 0.0204872
EML4 echinoderm microtubule associated protein like 4 0.020281
BABAM2 BRISC and BRCA1 A complex member 2 0.0196728
BRD2 bromodomain containing 2 0.0193664
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0192617
RABGAP1L RAB GTPase activating protein 1-like 0.0190474
HMGA2 high mobility group AT-hook 2 0.0188973
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0188896
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0187711
ANKRD36 ankyrin repeat domain 36 0.0187169
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0184708
ZNF638 zinc finger protein 638 0.0184319
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0183847
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0181012
MSN moesin 0.0180936
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.018023
NUP58 nucleoporin 58 0.0179801
KDM2A lysine (K)-specific demethylase 2A 0.0178691
NCKAP1 NCK-associated protein 1 0.01786
VMP1 vacuole membrane protein 1 0.0178251
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0175557
UBE2H ubiquitin-conjugating enzyme E2H 0.0175474
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.017185
TRIP12 thyroid hormone receptor interactor 12 0.0171314
PDE10A phosphodiesterase 10A 0.0170494
GMDS GDP-mannose 4,6-dehydratase 0.0167199
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0166822
SFPQ splicing factor proline/glutamine-rich 0.016681
SP3 Sp3 transcription factor 0.016572
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0164813
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0162057
SRPK1 SRSF protein kinase 1 0.0161979
FNDC3B fibronectin type III domain containing 3B 0.0161414
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0160048
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0159994
ZFC3H1 zinc finger, C3H1-type containing 0.0159928
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0159686
TRA2A transformer 2 alpha homolog (Drosophila) 0.0157123
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0154347
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0153944
EXOC4 exocyst complex component 4 0.0153131
CCNL1 cyclin L1 0.015194
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0151871
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.015162
DIAPH2 diaphanous-related formin 2 0.0150507
MED13L mediator complex subunit 13-like 0.0148942

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.146262
VIM vimentin -0.0733457
TMSB10 thymosin beta 10 -0.0721751
RPL12 ribosomal protein L12 -0.0468271
RPS21 ribosomal protein S21 -0.0450818
RPS3 ribosomal protein S3 -0.0398121
TPT1 tumor protein, translationally-controlled 1 -0.0389845
TFPI2 tissue factor pathway inhibitor 2 -0.0384967
RPL26 ribosomal protein L26 -0.0382738
MT2A metallothionein 2A -0.0381068
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0376062
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0372833
RPLP1 ribosomal protein, large, P1 -0.0335836
RPL35A ribosomal protein L35a -0.0329146
MYL12B myosin, light chain 12B, regulatory -0.032874
RPL37A ribosomal protein L37a -0.0321303
RPL34 ribosomal protein L34 -0.0321055
RPS8 ribosomal protein S8 -0.0307315
RPS27A ribosomal protein S27a -0.0306524
PTMA prothymosin, alpha -0.0300349
RPL5 ribosomal protein L5 -0.0297367
RPL38 ribosomal protein L38 -0.0296912
FTL ferritin, light polypeptide -0.0282775
ACTG1 actin gamma 1 -0.0277202
RPL32 ribosomal protein L32 -0.0277125
RPL8 ribosomal protein L8 -0.0276331
RPS24 ribosomal protein S24 -0.0271918
RPS29 ribosomal protein S29 -0.0255128
RPS4X ribosomal protein S4, X-linked -0.0255053
RPLP0 ribosomal protein, large, P0 -0.0254434
RPL9 ribosomal protein L9 -0.0254222
RPL31 ribosomal protein L31 -0.0250003
RPLP2 ribosomal protein, large, P2 -0.0249859
RPL11 ribosomal protein L11 -0.0248094
RPL19 ribosomal protein L19 -0.0244817
VDAC1 voltage-dependent anion channel 1 -0.024342
RPS27 ribosomal protein S27 -0.0237395
GNAS GNAS complex locus -0.0237035
RPS19 ribosomal protein S19 -0.0230263
ATP5F1E ATP synthase F1 subunit epsilon -0.02173
YBX3 Y box binding protein 3 -0.0215541
PFN1 profilin 1 -0.0215407
RPL36 ribosomal protein L36 -0.0214915
RPS15 ribosomal protein S15 -0.0209325
BSG basigin (Ok blood group) -0.0208973
RPS12 ribosomal protein S12 -0.0208121
RPS5 ribosomal protein S5 -0.0207084
EGR1 early growth response 1 -0.0205942
RPL23 ribosomal protein L23 -0.0205221
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0204191
RACK1 receptor for activated C kinase 1 -0.0196851
RPL37 ribosomal protein L37 -0.0195718
TPI1 triosephosphate isomerase 1 -0.019337
RPL35 ribosomal protein L35 -0.0192345
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0186248
GSTP1 glutathione S-transferase pi 1 -0.0182465
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0179315
IGF1R insulin-like growth factor 1 receptor -0.0176823
PDIA4 protein disulfide isomerase family A, member 4 -0.0169245
RPS6 ribosomal protein S6 -0.0166566
RPS16 ribosomal protein S16 -0.0162604
RPL28 ribosomal protein L28 -0.0160478
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0159332
RPS23 ribosomal protein S23 -0.0158845
ATF6 activating transcription factor 6 -0.0157294
RPL13A ribosomal protein L13a -0.0156918
NAP1L1 nucleosome assembly protein 1-like 1 -0.0155335
LOC112694756 uncharaterized LOC112694756 -0.0152756
EIF1 eukaryotic translation initiation factor 1 -0.0152064
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0148769
TXNRD1 thioredoxin reductase 1 -0.0148679
ATP5F1B ATP synthase F1 subunit beta -0.0148159
RPS13 ribosomal protein S13 -0.0145782
RPS25 ribosomal protein S25 -0.01439
RPS10 ribosomal protein S10 -0.0141239
RPS17 ribosomal protein S17 -0.0141222
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.013975
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.013143
KDSR 3-ketodihydrosphingosine reductase -0.0131375
RPL18 ribosomal protein L18 -0.01312
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0130133
HMGA1 high mobility group AT-hook 1 -0.0127379
RPL30 ribosomal protein L30 -0.0127267
RAN RAN, member RAS oncogene family -0.0127003
GARS1 glycyl-tRNA synthetase 1 -0.0126918
UBTF upstream binding transcription factor, RNA polymerase I -0.0123648
EEF2 eukaryotic translation elongation factor 2 -0.0122304
RPS20 ribosomal protein S20 -0.0121777
SRP72 signal recognition particle 72kDa -0.0121089
ZFR zinc finger RNA binding protein -0.0119502
RPS2 ribosomal protein S2 -0.0118954
UBB ubiquitin B -0.0114351
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0114059
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0113969
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0113611
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -0.0112808
TBCA tubulin folding cofactor A -0.0111085
RPS14 ribosomal protein S14 -0.0110749
LMAN1 lectin, mannose-binding, 1 -0.0110725
KMT2A lysine (K)-specific methyltransferase 2A -0.0110644