| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Canagliflozin_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0798267 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0714745 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0714719 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0584824 |
| MYO6 | myosin VI | 0.0546726 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0544653 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0542495 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0521276 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0493098 |
| MSN | moesin | 0.048085 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.047257 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0470055 |
| RCOR1 | REST corepressor 1 | 0.0465143 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0438117 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0420678 |
| ERBIN | erbb2 interacting protein | 0.0376866 |
| PTK2 | protein tyrosine kinase 2 | 0.0376453 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0369149 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0364486 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0362636 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0355674 |
| LDHA | lactate dehydrogenase A | 0.0352856 |
| UBC | ubiquitin C | 0.034512 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0339578 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0337653 |
| GOLGA4 | golgin A4 | 0.0333721 |
| DTNA | dystrobrevin, alpha | 0.0311892 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0309094 |
| POTEF | POTE ankyrin domain family, member F | 0.0307754 |
| FBXO32 | F-box protein 32 | 0.0300942 |
| SETD5 | SET domain containing 5 | 0.029373 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0290415 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.02869 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0274316 |
| TMF1 | TATA element modulatory factor 1 | 0.027375 |
| PDLIM5 | PDZ and LIM domain 5 | 0.027242 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0270625 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0268603 |
| GOLGB1 | golgin B1 | 0.0256533 |
| BBX | bobby sox homolog (Drosophila) | 0.0256303 |
| MCL1 | myeloid cell leukemia 1 | 0.0256137 |
| RAI14 | retinoic acid induced 14 | 0.0252047 |
| CD109 | CD109 molecule | 0.0249804 |
| VEGFA | vascular endothelial growth factor A | 0.0249352 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0248305 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0247727 |
| COPA | coatomer protein complex, subunit alpha | 0.0244715 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0244276 |
| FAM13A | family with sequence similarity 13, member A | 0.0243839 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0241688 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0240636 |
| NDRG1 | N-myc downstream regulated 1 | 0.023964 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0237693 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0234514 |
| CTBP2 | C-terminal binding protein 2 | 0.023175 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0229876 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0229802 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0226774 |
| OCLN | occludin | 0.0225176 |
| SRP54 | signal recognition particle 54kDa | 0.0214374 |
| EFNA5 | ephrin-A5 | 0.0212344 |
| MYO1E | myosin IE | 0.0211747 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0210867 |
| VMP1 | vacuole membrane protein 1 | 0.0209864 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0208725 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0208038 |
| WASF2 | WAS protein family, member 2 | 0.0207392 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0206808 |
| TMEM165 | transmembrane protein 165 | 0.0203914 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | 0.0203386 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0202752 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0201543 |
| NAV2 | neuron navigator 2 | 0.0201296 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0200437 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0200423 |
| ARHGAP20 | Rho GTPase activating protein 20 | 0.0200229 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0200161 |
| DSPP | dentin sialophosphoprotein | 0.0199805 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0199538 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0197952 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0197763 |
| FNBP4 | formin binding protein 4 | 0.01965 |
| MCU | mitochondrial calcium uniporter | 0.0196408 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0195156 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0194062 |
| FNIP1 | folliculin interacting protein 1 | 0.0193849 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0192819 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0191863 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0191489 |
| FLNB | filamin B, beta | 0.0189413 |
| SCFD1 | sec1 family domain containing 1 | 0.0187243 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.0187147 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0182037 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0180566 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0179601 |
| VCL | vinculin | 0.0178927 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0178593 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0176479 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0176162 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0175967 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.128922 |
| TMSB10 | thymosin beta 10 | -0.0846562 |
| FTL | ferritin, light polypeptide | -0.0682485 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0545035 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0525364 |
| RPL35A | ribosomal protein L35a | -0.0454478 |
| FN1 | fibronectin 1 | -0.0382338 |
| RPLP1 | ribosomal protein, large, P1 | -0.0338776 |
| RPL34 | ribosomal protein L34 | -0.032996 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0296776 |
| SDC4 | syndecan 4 | -0.0266484 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.02555 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0217124 |
| RPL12 | ribosomal protein L12 | -0.0200533 |
| RPS19 | ribosomal protein S19 | -0.0190508 |
| RPL8 | ribosomal protein L8 | -0.0181582 |
| RPLP2 | ribosomal protein, large, P2 | -0.0179963 |
| RPL32 | ribosomal protein L32 | -0.0175656 |
| RPL4 | ribosomal protein L4 | -0.0174333 |
| MT2A | metallothionein 2A | -0.0174114 |
| S100A6 | S100 calcium binding protein A6 | -0.0173963 |
| S100A10 | S100 calcium binding protein A10 | -0.0172814 |
| PTMA | prothymosin, alpha | -0.0165335 |
| SLC38A1 | solute carrier family 38, member 1 | -0.016474 |
| MATR3 | matrin 3 | -0.0162663 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0162114 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0161421 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | -0.0158841 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0157605 |
| GNAS | GNAS complex locus | -0.0155433 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0154974 |
| RPS24 | ribosomal protein S24 | -0.015494 |
| RPL38 | ribosomal protein L38 | -0.0154807 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.015479 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0153687 |
| FAM162A | family with sequence similarity 162, member A | -0.0150967 |
| RPS29 | ribosomal protein S29 | -0.0150696 |
| RPS27 | ribosomal protein S27 | -0.0147798 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0147642 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0143208 |
| RACK1 | receptor for activated C kinase 1 | -0.0141728 |
| KLF6 | Kruppel-like factor 6 | -0.0139071 |
| LMO7 | LIM domain 7 | -0.0137214 |
| RPL35 | ribosomal protein L35 | -0.0132004 |
| RPS3 | ribosomal protein S3 | -0.0131252 |
| RPS27A | ribosomal protein S27a | -0.0129667 |
| RPL36 | ribosomal protein L36 | -0.0129203 |
| RPL19 | ribosomal protein L19 | -0.0124544 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0122985 |
| LOC112694756 | uncharaterized LOC112694756 | -0.012286 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0121752 |
| RPL31 | ribosomal protein L31 | -0.011823 |
| RPS23 | ribosomal protein S23 | -0.0117759 |
| IER3 | immediate early response 3 | -0.0116427 |
| YBX1 | Y box binding protein 1 | -0.0116111 |
| RPS6 | ribosomal protein S6 | -0.0115892 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0113597 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0113498 |
| RPS21 | ribosomal protein S21 | -0.0111755 |
| RPLP0 | ribosomal protein, large, P0 | -0.0110879 |
| RPS11 | ribosomal protein S11 | -0.0110337 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0110069 |
| NPC2 | Niemann-Pick disease, type C2 | -0.0108808 |
| RPL6 | ribosomal protein L6 | -0.0108369 |
| ARF1 | ADP-ribosylation factor 1 | -0.0108099 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0106893 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0104366 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0103418 |
| EREG | epiregulin | -0.0102674 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0101186 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0100905 |
| RPL37A | ribosomal protein L37a | -0.00986795 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.00983649 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.00982181 |
| OAZ1 | ornithine decarboxylase antizyme 1 | -0.00974841 |
| HMGA1 | high mobility group AT-hook 1 | -0.00969522 |
| RPS8 | ribosomal protein S8 | -0.00951308 |
| HMGB1 | high mobility group box 1 | -0.00950734 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0093158 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0092753 |
| SREK1IP1 | SREK1-interacting protein 1 | -0.00921759 |
| S100A9 | S100 calcium binding protein A9 | -0.00920167 |
| RAB1B | RAB1B, member RAS oncogene family | -0.00910825 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | -0.00893418 |
| RPL23 | ribosomal protein L23 | -0.00891568 |
| SYT1 | synaptotagmin I | -0.00887307 |
| RPS4X | ribosomal protein S4, X-linked | -0.00887029 |
| RPL36AL | ribosomal protein L36a-like | -0.00879215 |
| TUBB | tubulin, beta class I | -0.00866309 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.00846403 |
| YBX3 | Y box binding protein 3 | -0.00840071 |
| EHF | ets homologous factor | -0.00828844 |
| RPS5 | ribosomal protein S5 | -0.00822304 |
| ACTG1 | actin gamma 1 | -0.00815403 |
| TUBB4B | tubulin, beta 4B class IVb | -0.00815035 |
| RPL11 | ribosomal protein L11 | -0.00814605 |
| MYL12B | myosin, light chain 12B, regulatory | -0.00812452 |
| MUC20 | mucin 20, cell surface associated | -0.00809113 |
| RPS13 | ribosomal protein S13 | -0.00805529 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.00802329 |
