| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.173604 |
| MCL1 | myeloid cell leukemia 1 | 0.148296 |
| EFNA5 | ephrin-A5 | 0.137745 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.137008 |
| PDE10A | phosphodiesterase 10A | 0.134792 |
| GDA | guanine deaminase | 0.124675 |
| ASPH | aspartate beta-hydroxylase | 0.114062 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.10337 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0922819 |
| DST | dystonin | 0.0872414 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0853565 |
| COL5A2 | collagen, type V, alpha 2 | 0.0831676 |
| KYNU | kynureninase | 0.0808853 |
| PCBP3 | poly(rC) binding protein 3 | 0.0704197 |
| FNDC3B | fibronectin type III domain containing 3B | 0.067645 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0634484 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0633743 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0616193 |
| NPAS2 | neuronal PAS domain protein 2 | 0.056922 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0554675 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0542485 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0511314 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0510495 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0508997 |
| MSN | moesin | 0.0508811 |
| GRAMD1B | GRAM domain containing 1B | 0.0503671 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.049892 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0484668 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0469619 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0442393 |
| PYGL | phosphorylase, glycogen, liver | 0.0425726 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0422732 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0414665 |
| RPL7A | ribosomal protein L7a | 0.0413746 |
| MFF | mitochondrial fission factor | 0.0406617 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0406227 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0398802 |
| PTEN | phosphatase and tensin homolog | 0.0397569 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0392886 |
| RPS12 | ribosomal protein S12 | 0.0392617 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0388536 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0388187 |
| NRCAM | neuronal cell adhesion molecule | 0.0387536 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0381161 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0377007 |
| COL4A5 | collagen, type IV, alpha 5 | 0.0376152 |
| VMP1 | vacuole membrane protein 1 | 0.036544 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0364845 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | 0.0359559 |
| CTSC | cathepsin C | 0.0341348 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0337416 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0335944 |
| CDH13 | cadherin 13 | 0.0335942 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0335463 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0330508 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0329697 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0329216 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0323777 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0311041 |
| CD109 | CD109 molecule | 0.0309457 |
| FLNB | filamin B, beta | 0.0302342 |
| ATXN1 | ataxin 1 | 0.0294301 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0294258 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0294167 |
| RPL3 | ribosomal protein L3 | 0.0291488 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0285932 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0285313 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0283531 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0277314 |
| NEK7 | NIMA-related kinase 7 | 0.0268334 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0267623 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0266752 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0265173 |
| MYOF | myoferlin | 0.0261055 |
| RPL21 | ribosomal protein L21 | 0.0256509 |
| UTY | ubiquitously transcribed tetratricopeptide repeat containing, Y-linked | 0.0255161 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0253705 |
| FN1 | fibronectin 1 | 0.0251403 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.024449 |
| RPL37A | ribosomal protein L37a | 0.0244134 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0243658 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0238824 |
| DNER | delta/notch-like EGF repeat containing | 0.023806 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0237917 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0236338 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0231154 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0229956 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0229846 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.022945 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0227576 |
| EXOC4 | exocyst complex component 4 | 0.0225849 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0225656 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0223704 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0222421 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0221675 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0220065 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0219839 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0219096 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0218393 |
| RAB3B | RAB3B, member RAS oncogene family | 0.021824 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.226233 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.196432 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.119841 |
| PTMA | prothymosin, alpha | -0.106082 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0723781 |
| VIM | vimentin | -0.0673961 |
| CANX | calnexin | -0.0582845 |
| RPLP1 | ribosomal protein, large, P1 | -0.0556623 |
| RPL35A | ribosomal protein L35a | -0.0553617 |
| GNAS | GNAS complex locus | -0.0534881 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0520258 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0477632 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0453367 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0449736 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0445809 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0432731 |
| RPS24 | ribosomal protein S24 | -0.036137 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0336274 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0318502 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0311984 |
| RGS2 | regulator of G-protein signaling 2 | -0.0310817 |
| RPLP0 | ribosomal protein, large, P0 | -0.0304205 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0300102 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0297378 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0288571 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0277296 |
| HLA-B | major histocompatibility complex, class I, B | -0.0268222 |
| RPL34 | ribosomal protein L34 | -0.0261359 |
| USP3 | ubiquitin specific peptidase 3 | -0.0254506 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0254219 |
| VDAC1 | voltage-dependent anion channel 1 | -0.025412 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0254051 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0253056 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0246537 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0242135 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0238431 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0237125 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0236683 |
| RPL12 | ribosomal protein L12 | -0.0229171 |
| RPS6 | ribosomal protein S6 | -0.0218769 |
| WDR45B | WD repeat domain 45B | -0.021523 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0212848 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0210503 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.020968 |
| MATR3 | matrin 3 | -0.0207082 |
| HMGB1 | high mobility group box 1 | -0.0203767 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.020067 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0197488 |
| ARF1 | ADP-ribosylation factor 1 | -0.0191309 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0190048 |
| MORF4L2 | mortality factor 4 like 2 | -0.0188976 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0184309 |
| TKT | transketolase | -0.0182207 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0174485 |
| YBX1 | Y box binding protein 1 | -0.017445 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0173921 |
| TMEM123 | transmembrane protein 123 | -0.0170974 |
| FBXO11 | F-box protein 11 | -0.0170528 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0168357 |
| FOXC1 | forkhead box C1 | -0.0167749 |
| S100A10 | S100 calcium binding protein A10 | -0.016598 |
| RPL6 | ribosomal protein L6 | -0.0165113 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0164801 |
| FTL | ferritin, light polypeptide | -0.0163452 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0162221 |
| OGA | O-GlcNAcase | -0.0161764 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0161275 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0160994 |
| TMSB10 | thymosin beta 10 | -0.0160601 |
| TMEM263 | transmembrane protein 263 | -0.0158056 |
| STK17A | serine/threonine kinase 17a | -0.0156741 |
| RHOB | ras homolog family member B | -0.0155842 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0155117 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0154378 |
| TMSB4X | thymosin beta 4, X-linked | -0.0151543 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0150631 |
| FUS | FUS RNA binding protein | -0.0150468 |
| TUBB | tubulin, beta class I | -0.0150282 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0148099 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.014758 |
| RPS21 | ribosomal protein S21 | -0.0147278 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0146113 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0145712 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0144745 |
| S100A6 | S100 calcium binding protein A6 | -0.0143758 |
| HBP1 | HMG-box transcription factor 1 | -0.0143127 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0142835 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0141079 |
| PERP | PERP, TP53 apoptosis effector | -0.0136675 |
| ANXA2 | annexin A2 | -0.0136526 |
| NEFL | neurofilament, light polypeptide | -0.013593 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0135588 |
| CADM2 | cell adhesion molecule 2 | -0.0135041 |
| RPL4 | ribosomal protein L4 | -0.013448 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0134391 |
| FAM13A | family with sequence similarity 13, member A | -0.0133891 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0133773 |
| CBX3 | chromobox homolog 3 | -0.0133094 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0132881 |
| RPS28 | ribosomal protein S28 | -0.0132181 |
