Canagliflozin_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Canagliflozin perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Canagliflozin_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.108844
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0964932
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0683972
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.061756
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0610899
TMSB4X thymosin beta 4, X-linked 0.0518922
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.045448
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.044057
PEG10 paternally expressed 10 0.0432945
TSC22D2 TSC22 domain family, member 2 0.0404662
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0362527
ANXA1 annexin A1 0.0356085
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0352692
ZNF292 zinc finger protein 292 0.0338719
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0325161
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0316207
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0297858
MKI67 marker of proliferation Ki-67 0.0296066
RAI1 retinoic acid induced 1 0.0285152
NAMPT nicotinamide phosphoribosyltransferase 0.0283771
EMP1 epithelial membrane protein 1 0.0277873
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0275472
PUM1 pumilio RNA-binding family member 1 0.0269183
ADAM9 ADAM metallopeptidase domain 9 0.0261166
TPM3 tropomyosin 3 0.0258122
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.02559
TRIO trio Rho guanine nucleotide exchange factor 0.0254048
SRP54 signal recognition particle 54kDa 0.0252019
MATR3 matrin 3 0.0247758
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0242187
MTF2 metal response element binding transcription factor 2 0.0240808
CLTC clathrin, heavy chain (Hc) 0.0237476
CDC73 cell division cycle 73 0.0236709
PAWR PRKC, apoptosis, WT1, regulator 0.0231608
KPNB1 karyopherin (importin) beta 1 0.0228213
XPO1 exportin 1 0.0228054
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0226884
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0219848
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0217065
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0215575
LYPLA1 lysophospholipase I 0.0212391
CDC50A cell division cycle 50 P4-ATPase accessory subunit A 0.0208847
RHEB Ras homolog enriched in brain 0.0207352
RBM39 RNA binding motif protein 39 0.0205203
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0204845
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0204515
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0203396
DDX56 DEAD (Asp-Glu-Ala-Asp) box helicase 56 0.0202734
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0202215
ECT2 epithelial cell transforming 2 0.0200738
MRPS30 mitochondrial ribosomal protein S30 0.0199662
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0199277
QKI QKI, KH domain containing, RNA binding 0.0197378
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0196892
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0195108
DST dystonin 0.0193437
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0191522
RLF rearranged L-myc fusion 0.0191418
KMT2E lysine (K)-specific methyltransferase 2E 0.0191345
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0191185
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0190767
CXADR coxsackie virus and adenovirus receptor 0.0190741
CENPF centromere protein F, 350/400kDa 0.0190656
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0188787
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0188455
NCKAP1 NCK-associated protein 1 0.0188311
BCLAF1 BCL2-associated transcription factor 1 0.0187109
PCBP2 poly(rC) binding protein 2 0.0185535
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0185468
POTEF POTE ankyrin domain family, member F 0.0184747
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0183379
UBC ubiquitin C 0.0181704
FUBP1 far upstream element (FUSE) binding protein 1 0.0181395
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0178329
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0176006
ENAH enabled homolog (Drosophila) 0.017289
ARHGAP12 Rho GTPase activating protein 12 0.0172151
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0171022
SET SET nuclear proto-oncogene 0.0169859
SP3 Sp3 transcription factor 0.0169769
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0169346
TPX2 TPX2, microtubule-associated 0.0168987
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0168768
IPO7 importin 7 0.0168347
FXR1 fragile X mental retardation, autosomal homolog 1 0.0167117
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.01668
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6 0.0166445
RTN4 reticulon 4 0.0165768
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0165743
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0165586
CSDE1 cold shock domain containing E1, RNA-binding 0.0165428
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.016484
WDR43 WD repeat domain 43 0.0164198
EVI5 ecotropic viral integration site 5 0.0161873
CCNL1 cyclin L1 0.0160882
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0159955
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0159756
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0158346
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0155923
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.015574

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.152271
COL11A1 collagen, type XI, alpha 1 -0.125057
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.124199
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0982088
CADM2 cell adhesion molecule 2 -0.0948502
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0835999
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0656031
PCDH9 protocadherin 9 -0.0648653
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.061057
PCLO piccolo presynaptic cytomatrix protein -0.0566944
PARD3B par-3 family cell polarity regulator beta -0.0539868
ADGRL2 adhesion G protein-coupled receptor L2 -0.0533884
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0527818
GPC3 glypican 3 -0.0431334
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0413408
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0405513
PHIP pleckstrin homology domain interacting protein -0.0405366
COL5A2 collagen, type V, alpha 2 -0.0389857
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0383798
ADGRV1 adhesion G protein-coupled receptor V1 -0.0372457
WSB1 WD repeat and SOCS box containing 1 -0.0362155
SLIT2 slit homolog 2 (Drosophila) -0.0357639
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.034204
PTMA prothymosin, alpha -0.0334275
TENM3 teneurin transmembrane protein 3 -0.0332899
RAD51B RAD51 paralog B -0.0332445
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0322754
RPS8 ribosomal protein S8 -0.0316441
LRRC4C leucine rich repeat containing 4C -0.0296679
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0294853
TMSB10 thymosin beta 10 -0.0284937
NEBL nebulette -0.0284052
ANKRD12 ankyrin repeat domain 12 -0.0278392
COL1A2 collagen, type I, alpha 2 -0.0277908
BMPR1A bone morphogenetic protein receptor, type IA -0.0277038
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0273735
ZC3H12B zinc finger CCCH-type containing 12B -0.0263354
PCDH7 protocadherin 7 -0.0256714
TPT1 tumor protein, translationally-controlled 1 -0.0256087
DOCK5 dedicator of cytokinesis 5 -0.025578
CSMD3 CUB and Sushi multiple domains 3 -0.0254603
DSCAM Down syndrome cell adhesion molecule -0.0244632
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0237971
MRPS6 mitochondrial ribosomal protein S6 -0.0235923
RPL35A ribosomal protein L35a -0.0234891
RPS16 ribosomal protein S16 -0.0224888
RBM20 RNA binding motif protein 20 -0.0223337
SMYD3 SET and MYND domain containing 3 -0.0222983
FOXP2 forkhead box P2 -0.0219742
NRG1 neuregulin 1 -0.0217217
CDH19 cadherin 19, type 2 -0.0214387
HMCN1 hemicentin 1 -0.0213365
RIGI RNA sensor RIG-I -0.0210534
RPS6 ribosomal protein S6 -0.021048
SYT1 synaptotagmin I -0.0209736
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0202439
MPG N-methylpurine-DNA glycosylase -0.0197594
OSBPL10 oxysterol binding protein-like 10 -0.0195357
RPL9 ribosomal protein L9 -0.0194001
SIK2 salt-inducible kinase 2 -0.0192885
NCOR2 nuclear receptor corepressor 2 -0.0191009
NXN nucleoredoxin -0.018903
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0184874
ISG15 ISG15 ubiquitin-like modifier -0.0184108
NHSL1 NHS-like 1 -0.0183095
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0182161
ANKRD33B ankyrin repeat domain 33B -0.0181052
INTS6 integrator complex subunit 6 -0.0179739
PBX3 pre-B-cell leukemia homeobox 3 -0.0179237
GREB1L growth regulation by estrogen in breast cancer-like -0.0179118
MBD5 methyl-CpG binding domain protein 5 -0.0178296
JMJD1C jumonji domain containing 1C -0.0178282
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -0.0177275
RPL37A ribosomal protein L37a -0.0176246
RPL31 ribosomal protein L31 -0.0175317
CUX1 cut-like homeobox 1 -0.0174626
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0174558
TTC28 tetratricopeptide repeat domain 28 -0.0172975
MAML2 mastermind-like 2 (Drosophila) -0.0172938
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -0.0172588
ITGAV integrin, alpha V -0.0168777
KDM4B lysine (K)-specific demethylase 4B -0.0167672
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0167124
MEIS2 Meis homeobox 2 -0.0166934
GARRE1 granule associated Rac and RHOG effector 1 -0.0164636
ENO1 enolase 1, (alpha) -0.0163649
SLC44A5 solute carrier family 44, member 5 -0.0163479
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0163214
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0162383
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.0159783
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0158382
FST follistatin -0.0158116
SAMD4A sterile alpha motif domain containing 4A -0.0157699
UBN2 ubinuclein 2 -0.0155525
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0155461
KMT2C lysine (K)-specific methyltransferase 2C -0.0154236
NCAM2 neural cell adhesion molecule 2 -0.0153828
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -0.0152854
PGK1 phosphoglycerate kinase 1 -0.0151954
TBCA tubulin folding cofactor A -0.0151931