| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SOD2 | superoxide dismutase 2, mitochondrial | 0.177654 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.12929 |
| FN1 | fibronectin 1 | 0.106779 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0906536 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.059773 |
| ADM | adrenomedullin | 0.0591891 |
| MSN | moesin | 0.0512556 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0490168 |
| MT2A | metallothionein 2A | 0.0484409 |
| CADM1 | cell adhesion molecule 1 | 0.0465004 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0464537 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0453072 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.04364 |
| FRMD4A | FERM domain containing 4A | 0.0401466 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0362308 |
| RPL11 | ribosomal protein L11 | 0.0337492 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0328495 |
| RPL7A | ribosomal protein L7a | 0.0321178 |
| CCNL1 | cyclin L1 | 0.0304077 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0302415 |
| RPL9 | ribosomal protein L9 | 0.029794 |
| RPS6 | ribosomal protein S6 | 0.0294188 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0292895 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.028464 |
| HELZ | helicase with zinc finger | 0.0281524 |
| ARRDC3 | arrestin domain containing 3 | 0.0278028 |
| ZNF292 | zinc finger protein 292 | 0.0277959 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0276243 |
| RPS12 | ribosomal protein S12 | 0.0274478 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0273988 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.027075 |
| B2M | beta-2-microglobulin | 0.027019 |
| TSC22D2 | TSC22 domain family, member 2 | 0.026434 |
| RPS23 | ribosomal protein S23 | 0.0263877 |
| RPL36A | ribosomal protein L36a | 0.0262813 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.026073 |
| RPS10 | ribosomal protein S10 | 0.0254084 |
| RNF145 | ring finger protein 145 | 0.0245141 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0244814 |
| DSTN | destrin (actin depolymerizing factor) | 0.0243898 |
| DEPP1 | DEPP autophagy regulator 1 | 0.0242724 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0242271 |
| SPAG9 | sperm associated antigen 9 | 0.0242163 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0240075 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0230278 |
| RPS19 | ribosomal protein S19 | 0.0226995 |
| WTAP | Wilms tumor 1 associated protein | 0.0225013 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0224867 |
| ATP13A3 | ATPase type 13A3 | 0.0222588 |
| RPL19 | ribosomal protein L19 | 0.0220996 |
| RPL7 | ribosomal protein L7 | 0.0218982 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0214984 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0214886 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0212316 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.021061 |
| RTN4 | reticulon 4 | 0.020785 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0207488 |
| SBF2 | SET binding factor 2 | 0.0202964 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0200339 |
| PFKP | phosphofructokinase, platelet | 0.0199628 |
| SRGN | serglycin | 0.0197872 |
| RPL36 | ribosomal protein L36 | 0.019589 |
| RPL32 | ribosomal protein L32 | 0.0194501 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.019393 |
| RPLP2 | ribosomal protein, large, P2 | 0.01933 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.019316 |
| FAM13A | family with sequence similarity 13, member A | 0.0192497 |
| RPL21 | ribosomal protein L21 | 0.0190134 |
| DENND5A | DENN/MADD domain containing 5A | 0.0188776 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0187072 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0185027 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0184792 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0184611 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0184279 |
| RPLP0 | ribosomal protein, large, P0 | 0.0184275 |
| CALD1 | caldesmon 1 | 0.0183948 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0181922 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0176789 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0175638 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0172929 |
| TGFB2 | transforming growth factor, beta 2 | 0.0172619 |
| NONO | non-POU domain containing, octamer-binding | 0.0171604 |
| HBS1L | HBS1-like translational GTPase | 0.0170465 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0169965 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0169866 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0167879 |
| NUP58 | nucleoporin 58 | 0.0167056 |
| FMN1 | formin 1 | 0.016672 |
| ANLN | anillin, actin binding protein | 0.0165827 |
| SFXN1 | sideroflexin 1 | 0.0165208 |
| RPS3 | ribosomal protein S3 | 0.0163305 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0162878 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0162752 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0162153 |
| MKI67 | marker of proliferation Ki-67 | 0.016207 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0161879 |
| RPS13 | ribosomal protein S13 | 0.0159991 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0159228 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | 0.0158686 |
| CABIN1 | calcineurin binding protein 1 | 0.0158571 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.251 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.172686 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.166958 |
| CD44 | CD44 molecule (Indian blood group) | -0.138587 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.12061 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.112294 |
| AHNAK | AHNAK nucleoprotein | -0.0996098 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0965657 |
| GLIS3 | GLIS family zinc finger 3 | -0.0953172 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0925773 |
| CANX | calnexin | -0.0822638 |
| HMGA2 | high mobility group AT-hook 2 | -0.0806682 |
| CDH13 | cadherin 13 | -0.0804777 |
| ENO1 | enolase 1, (alpha) | -0.0793122 |
| HLA-B | major histocompatibility complex, class I, B | -0.0722429 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0708993 |
| IER3 | immediate early response 3 | -0.0641936 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0614725 |
| CALR | calreticulin | -0.0549396 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0538126 |
| STC1 | stanniocalcin 1 | -0.0532955 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0520607 |
| GOLGB1 | golgin B1 | -0.0519891 |
| VCL | vinculin | -0.0514693 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0512252 |
| HLA-E | major histocompatibility complex, class I, E | -0.0507535 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0475457 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0473629 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.045725 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0453777 |
| SMYD3 | SET and MYND domain containing 3 | -0.0444695 |
| DST | dystonin | -0.0438022 |
| SQSTM1 | sequestosome 1 | -0.0436575 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0435855 |
| PLIN2 | perilipin 2 | -0.0403744 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0400579 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0398408 |
| PHF3 | PHD finger protein 3 | -0.0393517 |
| INTS6 | integrator complex subunit 6 | -0.0388629 |
| VCAN | versican | -0.0383351 |
| RAI14 | retinoic acid induced 14 | -0.0376413 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0376086 |
| CTSB | cathepsin B | -0.0371484 |
| LDHA | lactate dehydrogenase A | -0.0371024 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0369848 |
| NAV1 | neuron navigator 1 | -0.0361649 |
| ANXA2 | annexin A2 | -0.0359111 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0356909 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0355707 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0346568 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0343191 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0342139 |
| RND3 | Rho family GTPase 3 | -0.03412 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0339021 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0337026 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0336813 |
| RPS27A | ribosomal protein S27a | -0.0332647 |
| BPTF | bromodomain PHD finger transcription factor | -0.0331912 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0331362 |
| ASPH | aspartate beta-hydroxylase | -0.0325764 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0324456 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0323168 |
| TAOK1 | TAO kinase 1 | -0.031587 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0315359 |
| HDLBP | high density lipoprotein binding protein | -0.0311438 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0308499 |
| UBC | ubiquitin C | -0.0305777 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0302495 |
| RRBP1 | ribosome binding protein 1 | -0.0300426 |
| EFNA5 | ephrin-A5 | -0.0290351 |
| FNIP1 | folliculin interacting protein 1 | -0.0289414 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0287946 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0284689 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0281519 |
| SFRP1 | secreted frizzled-related protein 1 | -0.028149 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0280606 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0273925 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0271681 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0271559 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0270143 |
| DIAPH2 | diaphanous-related formin 2 | -0.0267545 |
| COL1A1 | collagen, type I, alpha 1 | -0.0267344 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0266129 |
| FBXO11 | F-box protein 11 | -0.0265571 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0265531 |
| COL5A1 | collagen, type V, alpha 1 | -0.0265475 |
| NRN1 | neuritin 1 | -0.0265436 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0264769 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0263135 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.0261401 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0260992 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0260117 |
| INHBA | inhibin, beta A | -0.0258156 |
| GOLGA4 | golgin A4 | -0.025533 |
| TLN1 | talin 1 | -0.0252061 |
| PTMA | prothymosin, alpha | -0.0249301 |
| MORF4L2 | mortality factor 4 like 2 | -0.0248196 |
| VEGFA | vascular endothelial growth factor A | -0.0248011 |
| TPM4 | tropomyosin 4 | -0.0246993 |
| CUL4B | cullin 4B | -0.0246556 |
