| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Canagliflozin perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Canagliflozin_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0618352 |
| H3-3B | H3.3 histone B | 0.0582481 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0576782 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0499488 |
| WTAP | Wilms tumor 1 associated protein | 0.0488963 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0474144 |
| ARRDC3 | arrestin domain containing 3 | 0.0455121 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0451746 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0450512 |
| CADM1 | cell adhesion molecule 1 | 0.0445679 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0425647 |
| FAM13A | family with sequence similarity 13, member A | 0.0416531 |
| TNPO1 | transportin 1 | 0.0407857 |
| MT2A | metallothionein 2A | 0.0390791 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.037552 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0369827 |
| MED13L | mediator complex subunit 13-like | 0.0362516 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0360608 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0357087 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.035579 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0354316 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0353075 |
| MTSS1 | metastasis suppressor 1 | 0.0346832 |
| PHF3 | PHD finger protein 3 | 0.0343096 |
| FNDC3A | fibronectin type III domain containing 3A | 0.033989 |
| SARNP | SAP domain containing ribonucleoprotein | 0.0329575 |
| ANXA2 | annexin A2 | 0.0322786 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0321446 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0317964 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0313338 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0312767 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0309652 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0308691 |
| CD44 | CD44 molecule (Indian blood group) | 0.0304648 |
| XPO1 | exportin 1 | 0.0302331 |
| RLF | rearranged L-myc fusion | 0.0300374 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0297768 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0297427 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0294611 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0293599 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0291679 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0289565 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0283759 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.0282548 |
| NEK7 | NIMA-related kinase 7 | 0.0278515 |
| DTNA | dystrobrevin, alpha | 0.027842 |
| XPOT | exportin, tRNA | 0.0278258 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0276182 |
| QKI | QKI, KH domain containing, RNA binding | 0.0274748 |
| RUNX1 | runt-related transcription factor 1 | 0.0274237 |
| ZNF292 | zinc finger protein 292 | 0.0270772 |
| LMO7 | LIM domain 7 | 0.0270087 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0265678 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0262994 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | 0.0260677 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0260462 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0259572 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0257035 |
| UBC | ubiquitin C | 0.0256313 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | 0.0255944 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0252362 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0251658 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0250278 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0249693 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0242518 |
| YME1L1 | YME1-like 1 ATPase | 0.0239163 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.023849 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0236582 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0235832 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0234269 |
| MYO10 | myosin X | 0.0231469 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0231346 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0231328 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0228756 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0227682 |
| RC3H2 | ring finger and CCCH-type domains 2 | 0.0227612 |
| GOLGA4 | golgin A4 | 0.0227058 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0223547 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0222594 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0220066 |
| TPI1 | triosephosphate isomerase 1 | 0.0219932 |
| SETD5 | SET domain containing 5 | 0.0219895 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0219426 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0216054 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0215137 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0214283 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0213657 |
| RPL4 | ribosomal protein L4 | 0.0212928 |
| FAM168A | family with sequence similarity 168, member A | 0.021191 |
| RCN1 | reticulocalbin 1, EF-hand calcium binding domain | 0.0211721 |
| TPM1 | tropomyosin 1 (alpha) | 0.0211279 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0209768 |
| TNPO3 | transportin 3 | 0.0209177 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0209034 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0208765 |
| PIAS1 | protein inhibitor of activated STAT, 1 | 0.0207361 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0206149 |
| CORO1C | coronin, actin binding protein, 1C | 0.0206017 |
| BBX | bobby sox homolog (Drosophila) | 0.020576 |
| CSTB | cystatin B (stefin B) | 0.0203527 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.272024 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.128136 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.105986 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0992294 |
| EGFR | epidermal growth factor receptor | -0.0785964 |
| CDH13 | cadherin 13 | -0.0751077 |
| NRXN3 | neurexin 3 | -0.0727657 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0667514 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0627793 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.061003 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0537836 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0504774 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0491332 |
| CANX | calnexin | -0.0490563 |
| IL6 | interleukin 6 | -0.0469922 |
| VIM | vimentin | -0.0461796 |
| COL5A1 | collagen, type V, alpha 1 | -0.0422587 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0421548 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0420661 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.041971 |
| VEGFA | vascular endothelial growth factor A | -0.0404513 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.039956 |
| SEC24D | SEC24 family member D | -0.0397488 |
| RRBP1 | ribosome binding protein 1 | -0.0386556 |
| HLA-B | major histocompatibility complex, class I, B | -0.0385878 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0381218 |
| RAI14 | retinoic acid induced 14 | -0.0376135 |
| ATXN1 | ataxin 1 | -0.0374171 |
| TNS3 | tensin 3 | -0.0373482 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0372334 |
| CALD1 | caldesmon 1 | -0.0368517 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0347738 |
| ENO1 | enolase 1, (alpha) | -0.0342523 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0337215 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0334093 |
| SMYD3 | SET and MYND domain containing 3 | -0.0324433 |
| CDK13 | cyclin-dependent kinase 13 | -0.0319126 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0318305 |
| AHNAK | AHNAK nucleoprotein | -0.0316071 |
| BLTP1 | bridge-like lipid transfer protein family member 1 | -0.0315048 |
| HLA-C | major histocompatibility complex, class I, C | -0.0309361 |
| VCL | vinculin | -0.0306334 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0299792 |
| STC1 | stanniocalcin 1 | -0.0296958 |
| COG6 | component of oligomeric golgi complex 6 | -0.029521 |
| GSE1 | Gse1 coiled-coil protein | -0.0290772 |
| CALR | calreticulin | -0.0288659 |
| POTEF | POTE ankyrin domain family, member F | -0.0277994 |
| EXOC4 | exocyst complex component 4 | -0.0277056 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0270177 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0269778 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0269107 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0268837 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0266419 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.026527 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0265046 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0264323 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0264232 |
| VEGFC | vascular endothelial growth factor C | -0.0261665 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0260704 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0258921 |
| SEC24A | SEC24 family member A | -0.0258586 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0258551 |
| ACTN1 | actinin, alpha 1 | -0.0255514 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0255011 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0252046 |
| RAD51B | RAD51 paralog B | -0.0248829 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0246027 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0243814 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0241873 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0240653 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0240525 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0240184 |
| FNIP1 | folliculin interacting protein 1 | -0.0238935 |
| MAP1B | microtubule-associated protein 1B | -0.023649 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | -0.0234526 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0234333 |
| LDHA | lactate dehydrogenase A | -0.0224033 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.022389 |
| ZNF638 | zinc finger protein 638 | -0.0222488 |
| FRMD4A | FERM domain containing 4A | -0.0218881 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0218733 |
| WWOX | WW domain containing oxidoreductase | -0.0216887 |
| TMEM165 | transmembrane protein 165 | -0.0216792 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0215626 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0211792 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0211508 |
| FAM20C | family with sequence similarity 20, member C | -0.0210762 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0210456 |
| GPATCH2L | G patch domain containing 2-like | -0.0209456 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0207875 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0207261 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0206235 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | -0.0205605 |
| PCNX4 | pecanex 4 | -0.0205257 |
| STC2 | stanniocalcin 2 | -0.0205234 |
| SBF2 | SET binding factor 2 | -0.0203963 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0202677 |
| NAV1 | neuron navigator 1 | -0.0202265 |
| TPM4 | tropomyosin 4 | -0.0202133 |
