Cancer Cachexia Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link https://www.disgenet.org/browser/0/1/0/C1391732
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Genes

106 genes associated with the disease Cancer Cachexia in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACE2 angiotensin I converting enzyme 2
ACVR2A activin A receptor, type IIA
ACVR2B activin A receptor, type IIB
ADRB1 adrenoceptor beta 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ANGPTL4 angiopoietin-like 4
AR androgen receptor
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CLEC1B C-type lectin domain family 1, member B
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRP C-reactive protein, pentraxin-related
CSF3 colony stimulating factor 3 (granulocyte)
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
DCD dermcidin
DNER delta/notch-like EGF repeat containing
EPHB2 EPH receptor B2
FADD Fas (TNFRSF6)-associated via death domain
FBXO32 F-box protein 32
FOXO3 forkhead box O3
FST follistatin
GCG glucagon
GDF15 growth differentiation factor 15
GH1 growth hormone 1
GHRH growth hormone releasing hormone
GHSR growth hormone secretagogue receptor
GRAP2 GRB2-related adaptor protein 2
GSK3B glycogen synthase kinase 3 beta
HCRT hypocretin (orexin) neuropeptide precursor
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA4 heat shock 70kDa protein 4
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL13 interleukin 13
IL15 interleukin 15
IL1A interleukin 1, alpha
IL1RN interleukin 1 receptor antagonist
IL4 interleukin 4
IL6 interleukin 6
JAK2 Janus kinase 2
KRT10 keratin 10, type I
LBP lipopolysaccharide binding protein
LCN2 lipocalin 2
LEP leptin
LIF leukemia inhibitory factor
LIPE lipase, hormone-sensitive
MAP2K1 mitogen-activated protein kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MC4R melanocortin 4 receptor
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MSTN myostatin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYD88 myeloid differentiation primary response 88
NMU neuromedin U
NPY neuropeptide Y
OSM oncostatin M
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAX7 paired box 7
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PLIN1 perilipin 1
PNPLA2 patatin-like phospholipase domain containing 2
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTHLH parathyroid hormone-like hormone
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REN renin
RMC1 regulator of MON1-CCZ1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TGFB1 transforming growth factor, beta 1
TICAM1 toll-like receptor adaptor molecule 1
TLR4 toll-like receptor 4
TLR7 toll-like receptor 7
TNF tumor necrosis factor
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAP triiodothyronine receptor auxiliary protein
TRIM63 tripartite motif containing 63, E3 ubiquitin protein ligase
TRIM69 tripartite motif containing 69
TSC22D1 TSC22 domain family, member 1
TSC22D4 TSC22 domain family, member 4
TWIST1 twist family bHLH transcription factor 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
XBP1 X-box binding protein 1