Canonical Wnt signaling pathway Gene Set

Dataset PID Pathways
Category structural or functional annotations
Type pathway
Description The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. (Gene Ontology, GO_0060070)
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20 proteins participating in the Canonical Wnt signaling pathway pathway from the PID Pathways dataset.

Symbol Name
APC adenomatous polyposis coli
AXIN1 axin 1
CAV1 caveolin 1, caveolae protein, 22kDa
CSNK1G1 casein kinase 1, gamma 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL3 cullin 3
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
FZD5 frizzled class receptor 5
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
KLHL12 kelch-like family member 12
LRP6 low density lipoprotein receptor-related protein 6
NKD2 naked cuticle homolog 2 (Drosophila)
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
RANBP3 RAN binding protein 3
WNT3A wingless-type MMTV integration site family, member 3A