| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Capivasertib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PODXL | podocalyxin-like | 0.182803 |
| CDH13 | cadherin 13 | 0.13511 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.127739 |
| SLC39A11 | solute carrier family 39, member 11 | 0.114484 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.107363 |
| COL5A1 | collagen, type V, alpha 1 | 0.102838 |
| NAV1 | neuron navigator 1 | 0.0985533 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0881816 |
| EGFR | epidermal growth factor receptor | 0.0821165 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.080317 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0791442 |
| FSTL1 | follistatin-like 1 | 0.0785439 |
| NAV2 | neuron navigator 2 | 0.0764602 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.071914 |
| FLNA | filamin A, alpha | 0.0713087 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0700143 |
| SEPTIN9 | septin 9 | 0.0658993 |
| HDAC9 | histone deacetylase 9 | 0.0627444 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.0620319 |
| PLAT | plasminogen activator, tissue | 0.0566095 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0565846 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0562452 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.053696 |
| EFNA5 | ephrin-A5 | 0.0533176 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0507567 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0493769 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0486441 |
| MSN | moesin | 0.0483825 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0472766 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0459417 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0450401 |
| MAP1B | microtubule-associated protein 1B | 0.0445256 |
| ASPH | aspartate beta-hydroxylase | 0.0440395 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0437198 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.042527 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0414845 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0413296 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0411641 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0411361 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0393899 |
| CD44 | CD44 molecule (Indian blood group) | 0.0385723 |
| POTEF | POTE ankyrin domain family, member F | 0.0382994 |
| TPM3 | tropomyosin 3 | 0.0378366 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0377065 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.03753 |
| L1CAM | L1 cell adhesion molecule | 0.0371959 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0368667 |
| APP | amyloid beta (A4) precursor protein | 0.0365423 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0364731 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0358881 |
| DGKG | diacylglycerol kinase, gamma 90kDa | 0.0358351 |
| MCL1 | myeloid cell leukemia 1 | 0.0355221 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | 0.0354816 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0354241 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0350949 |
| CYTH3 | cytohesin 3 | 0.0349776 |
| PLEC | plectin | 0.0343822 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | 0.0333335 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0325652 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0322314 |
| SMYD3 | SET and MYND domain containing 3 | 0.0320264 |
| PRKCE | protein kinase C, epsilon | 0.0315213 |
| INTS6 | integrator complex subunit 6 | 0.031199 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0311659 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0309814 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0308471 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0306435 |
| RASAL2 | RAS protein activator like 2 | 0.030396 |
| SMAD3 | SMAD family member 3 | 0.0303389 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0293176 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0292485 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | 0.028686 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0279585 |
| EXT1 | exostosin glycosyltransferase 1 | 0.02794 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0276634 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0276201 |
| BCL2L1 | BCL2-like 1 | 0.0270297 |
| PLXNA2 | plexin A2 | 0.026419 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0262574 |
| ERBIN | erbb2 interacting protein | 0.0261129 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.025814 |
| E2F7 | E2F transcription factor 7 | 0.0255913 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0255376 |
| PRELID2 | PRELI domain containing 2 | 0.0254676 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0250217 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0248306 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0247418 |
| FAM219A | family with sequence similarity 219, member A | 0.0245537 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0236792 |
| TLE4 | transducin-like enhancer of split 4 | 0.0234629 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0231774 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.02315 |
| AGRN | agrin | 0.0230826 |
| OR51B5 | olfactory receptor, family 51, subfamily B, member 5 | 0.0228712 |
| ZNF638 | zinc finger protein 638 | 0.0228486 |
| KIAA1549L | KIAA1549-like | 0.0228463 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.0226124 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.022537 |
| SPG7 | spastic paraplegia 7 (pure and complicated autosomal recessive) | 0.0224731 |
| C1D | C1D nuclear receptor corepressor | 0.0224563 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.173725 |
| FBN1 | fibrillin 1 | -0.147751 |
| TMSB10 | thymosin beta 10 | -0.141893 |
| VIM | vimentin | -0.128674 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.104384 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0876821 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0864248 |
| UBC | ubiquitin C | -0.07594 |
| PTMA | prothymosin, alpha | -0.0683022 |
| MT2A | metallothionein 2A | -0.0674709 |
| COL1A2 | collagen, type I, alpha 2 | -0.0663702 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0661026 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0595953 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0585225 |
| B2M | beta-2-microglobulin | -0.0565055 |
| LOX | lysyl oxidase | -0.0554935 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0516682 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0508316 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0489264 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0459602 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0452608 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.04511 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0442284 |
| FTL | ferritin, light polypeptide | -0.0431016 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0429212 |
| IER3 | immediate early response 3 | -0.0427134 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0425328 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0422897 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0420048 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0417481 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0415857 |
| MEIS2 | Meis homeobox 2 | -0.0415263 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0412093 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.0393423 |
| WTAP | Wilms tumor 1 associated protein | -0.0384896 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0383938 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0382905 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0381415 |
| COL3A1 | collagen, type III, alpha 1 | -0.0381279 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0375167 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0364571 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0356711 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0334126 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0325551 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.032359 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0309833 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0308007 |
| S100A10 | S100 calcium binding protein A10 | -0.0305895 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0305706 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0303227 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0298732 |
| ANXA2 | annexin A2 | -0.0297801 |
| OGA | O-GlcNAcase | -0.029237 |
| HLA-E | major histocompatibility complex, class I, E | -0.0290618 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0287089 |
| FRMD5 | FERM domain containing 5 | -0.0286208 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0278634 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0275564 |
| GNAS | GNAS complex locus | -0.0271281 |
| FAM162A | family with sequence similarity 162, member A | -0.0267007 |
| S100A6 | S100 calcium binding protein A6 | -0.0266986 |
| SBF2 | SET binding factor 2 | -0.0265358 |
| ADM | adrenomedullin | -0.0259721 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0257411 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0256037 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0254994 |
| LOXL2 | lysyl oxidase-like 2 | -0.0253009 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0248857 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0248349 |
| RBM39 | RNA binding motif protein 39 | -0.024792 |
| MATR3 | matrin 3 | -0.0245453 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0242993 |
| MX2 | MX dynamin-like GTPase 2 | -0.0240774 |
| STC1 | stanniocalcin 1 | -0.0240603 |
| GPC6 | glypican 6 | -0.0240154 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0238332 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0237087 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.02368 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0234491 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0234274 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0230766 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0230182 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.022761 |
| PGK1 | phosphoglycerate kinase 1 | -0.0225202 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0223013 |
| TXNIP | thioredoxin interacting protein | -0.0222426 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.0220255 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0218398 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0217899 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0217171 |
| RLF | rearranged L-myc fusion | -0.0216491 |
| INSIG2 | insulin induced gene 2 | -0.0215462 |
| FNBP1 | formin binding protein 1 | -0.0211246 |
| RPL35A | ribosomal protein L35a | -0.0209121 |
| MT1X | metallothionein 1X | -0.0208067 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0207843 |
| CLU | clusterin | -0.0207326 |
| RNF145 | ring finger protein 145 | -0.0205611 |
| PRKD1 | protein kinase D1 | -0.0205334 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0205239 |
