| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Capivasertib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| JMJD1C | jumonji domain containing 1C | 0.120441 |
| AREG | amphiregulin | 0.118924 |
| HMGA2 | high mobility group AT-hook 2 | 0.0948764 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0913223 |
| RPS12 | ribosomal protein S12 | 0.084103 |
| RRM2 | ribonucleotide reductase M2 | 0.0835819 |
| YAP1 | Yes-associated protein 1 | 0.0803099 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0741138 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0729646 |
| RPL37A | ribosomal protein L37a | 0.0725579 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0703949 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0666728 |
| PDGFC | platelet derived growth factor C | 0.0655984 |
| RPS3 | ribosomal protein S3 | 0.0652722 |
| VMP1 | vacuole membrane protein 1 | 0.0648331 |
| INTS6 | integrator complex subunit 6 | 0.06281 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0623658 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0622636 |
| RTN4 | reticulon 4 | 0.0573352 |
| NHSL1 | NHS-like 1 | 0.0569223 |
| RCOR1 | REST corepressor 1 | 0.0542762 |
| DENND5A | DENN/MADD domain containing 5A | 0.0534408 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0531819 |
| ASPH | aspartate beta-hydroxylase | 0.0520609 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0517805 |
| USP34 | ubiquitin specific peptidase 34 | 0.0511472 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0488658 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0484299 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0466431 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0461949 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0440664 |
| WWOX | WW domain containing oxidoreductase | 0.043729 |
| RPL27 | ribosomal protein L27 | 0.0436761 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0424716 |
| ARHGEF11 | Rho guanine nucleotide exchange factor (GEF) 11 | 0.0416948 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0416363 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0415565 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0405915 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0405763 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0402049 |
| RPS29 | ribosomal protein S29 | 0.0398709 |
| PCDH9 | protocadherin 9 | 0.0391697 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0381756 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0375839 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0373844 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0371155 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0369844 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0364688 |
| RAD51B | RAD51 paralog B | 0.0364161 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0359616 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0357294 |
| NEBL | nebulette | 0.0344956 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.034408 |
| RPS2 | ribosomal protein S2 | 0.0333332 |
| EPHA6 | EPH receptor A6 | 0.0329203 |
| TNRC18 | trinucleotide repeat containing 18 | 0.0328635 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0328479 |
| PRELID2 | PRELI domain containing 2 | 0.0328286 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.032658 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0325523 |
| ATXN2 | ataxin 2 | 0.0323522 |
| RPL28 | ribosomal protein L28 | 0.0322578 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.0319813 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0319555 |
| BRD2 | bromodomain containing 2 | 0.031356 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0312766 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0310981 |
| MCL1 | myeloid cell leukemia 1 | 0.0310913 |
| RPL37 | ribosomal protein L37 | 0.0309443 |
| ZNF638 | zinc finger protein 638 | 0.0308026 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0303769 |
| RPL13A | ribosomal protein L13a | 0.0302546 |
| ATP11A | ATPase, class VI, type 11A | 0.0299923 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0298897 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0298232 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0296999 |
| CEP192 | centrosomal protein 192kDa | 0.029311 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0290275 |
| RPLP2 | ribosomal protein, large, P2 | 0.0290216 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0288717 |
| DENND1A | DENN/MADD domain containing 1A | 0.0288022 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0287967 |
| FAM193A | family with sequence similarity 193, member A | 0.0281332 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0280885 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0278329 |
| RPL3 | ribosomal protein L3 | 0.027693 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0276398 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0271161 |
| RPL9 | ribosomal protein L9 | 0.0270296 |
| RPL11 | ribosomal protein L11 | 0.0270076 |
| PFN1 | profilin 1 | 0.0269593 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0268659 |
| UBAP2 | ubiquitin associated protein 2 | 0.0267363 |
| KMT2D | lysine (K)-specific methyltransferase 2D | 0.0267311 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0264893 |
| TMEM41B | transmembrane protein 41B | 0.0263004 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.0262884 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0262879 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0262043 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0261334 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.214494 |
| VIM | vimentin | -0.206771 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.118963 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0862638 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0810672 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0809312 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0751174 |
| FTL | ferritin, light polypeptide | -0.074571 |
| MMP12 | matrix metallopeptidase 12 | -0.0734352 |
| PTMA | prothymosin, alpha | -0.0723426 |
| TMEM123 | transmembrane protein 123 | -0.0651481 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0633588 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0624987 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0621605 |
| DST | dystonin | -0.0606146 |
| TXNRD1 | thioredoxin reductase 1 | -0.0555437 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0547018 |
| CLDN1 | claudin 1 | -0.0533329 |
| AHNAK | AHNAK nucleoprotein | -0.0522959 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0519119 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0515496 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.050867 |
| PCDH7 | protocadherin 7 | -0.0496279 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0488237 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0485584 |
| PLK2 | polo-like kinase 2 | -0.0479554 |
| CDK6 | cyclin-dependent kinase 6 | -0.0471028 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0463124 |
| RPLP1 | ribosomal protein, large, P1 | -0.0436727 |
| LMO7 | LIM domain 7 | -0.0430018 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0423415 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0417107 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0408416 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0403358 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0383149 |
| CANX | calnexin | -0.0372796 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0365217 |
| EDN1 | endothelin 1 | -0.0356512 |
| OXR1 | oxidation resistance 1 | -0.0352237 |
| CALR | calreticulin | -0.034681 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0336193 |
| HDLBP | high density lipoprotein binding protein | -0.0333007 |
| MYL12B | myosin, light chain 12B, regulatory | -0.032431 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0322926 |
| FSTL5 | follistatin-like 5 | -0.0315986 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0314204 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | -0.031209 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0310126 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | -0.0307444 |
| CCND1 | cyclin D1 | -0.0305365 |
| ZNF804A | zinc finger protein 804A | -0.0303405 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0300415 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0297866 |
| RPS24 | ribosomal protein S24 | -0.0296512 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0291286 |
| LMAN1 | lectin, mannose-binding, 1 | -0.029031 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0279775 |
| RPL34 | ribosomal protein L34 | -0.0277964 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0276766 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0274084 |
| YBX1 | Y box binding protein 1 | -0.0273809 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0273102 |
| HMGB1 | high mobility group box 1 | -0.0270627 |
| MATR3 | matrin 3 | -0.0268858 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0266621 |
| LDHA | lactate dehydrogenase A | -0.0266343 |
| DEK | DEK proto-oncogene | -0.0266163 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0265879 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0259316 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0259013 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0258813 |
| NARS1 | asparaginyl-tRNA synthetase 1 | -0.0258452 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | -0.0257813 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0257807 |
| RACK1 | receptor for activated C kinase 1 | -0.025449 |
| LDHB | lactate dehydrogenase B | -0.0254077 |
| RPLP0 | ribosomal protein, large, P0 | -0.0253223 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0250566 |
| BTG3 | BTG family, member 3 | -0.0249859 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0247162 |
| SKP1 | S-phase kinase-associated protein 1 | -0.0247151 |
| SYT1 | synaptotagmin I | -0.0246702 |
| ACTG1 | actin gamma 1 | -0.0244343 |
| HMGA1 | high mobility group AT-hook 1 | -0.0240811 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.024034 |
| KLF6 | Kruppel-like factor 6 | -0.0239823 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | -0.0239543 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.0239101 |
| NPR2 | natriuretic peptide receptor 2 | -0.0238126 |
| XPO1 | exportin 1 | -0.0237693 |
| DSG2 | desmoglein 2 | -0.0237346 |
| CXADR | coxsackie virus and adenovirus receptor | -0.023635 |
| RPL31 | ribosomal protein L31 | -0.0234385 |
| RPL6 | ribosomal protein L6 | -0.0232926 |
| RBM39 | RNA binding motif protein 39 | -0.023231 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.0232273 |
| APPL1 | adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 | -0.023051 |
| CBX3 | chromobox homolog 3 | -0.0230336 |
| RPL4 | ribosomal protein L4 | -0.0230335 |
| TUBA1B | tubulin, alpha 1b | -0.0229582 |
