Capivasertib_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capivasertib perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Capivasertib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.123573
SMAD3 SMAD family member 3 0.111112
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0933316
INTS6 integrator complex subunit 6 0.0775752
LMO7 LIM domain 7 0.0746108
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0742516
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0662631
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0623392
VCL vinculin 0.0597328
AKAP13 A kinase (PRKA) anchor protein 13 0.0539448
EXT1 exostosin glycosyltransferase 1 0.0524953
FNDC3B fibronectin type III domain containing 3B 0.0516375
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0513637
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0509373
SHB Src homology 2 domain containing adaptor protein B 0.0485732
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0435629
ANKRD10 ankyrin repeat domain 10 0.0414969
ANXA2 annexin A2 0.040102
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0384419
PRKCA protein kinase C, alpha 0.0367
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0352049
GMDS GDP-mannose 4,6-dehydratase 0.0346928
FNIP1 folliculin interacting protein 1 0.0335538
BCL2L1 BCL2-like 1 0.0334378
MAP7 microtubule-associated protein 7 0.0334356
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0321638
YAP1 Yes-associated protein 1 0.0319062
ARHGAP26 Rho GTPase activating protein 26 0.0316327
ERBIN erbb2 interacting protein 0.0314808
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0310662
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0309768
LPP LIM domain containing preferred translocation partner in lipoma 0.0309563
ANKRD17 ankyrin repeat domain 17 0.027365
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0271665
EFNB2 ephrin-B2 0.0270244
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0270109
PDZD8 PDZ domain containing 8 0.0268532
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0264549
MYH9 myosin, heavy chain 9, non-muscle 0.0257708
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0252692
MYO1E myosin IE 0.0249975
SPRED1 sprouty-related, EVH1 domain containing 1 0.0245815
TRIO trio Rho guanine nucleotide exchange factor 0.0242952
BTBD9 BTB (POZ) domain containing 9 0.0238542
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0237673
ASPH aspartate beta-hydroxylase 0.0235937
DIAPH1 diaphanous-related formin 1 0.0235686
MSI2 musashi RNA-binding protein 2 0.0230347
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0229737
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0228607
VMP1 vacuole membrane protein 1 0.0228529
STS steroid sulfatase (microsomal), isozyme S 0.0224845
USP53 ubiquitin specific peptidase 53 0.0223399
MCTP1 multiple C2 domains, transmembrane 1 0.0220355
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0218424
CTBP2 C-terminal binding protein 2 0.0218385
TOX3 TOX high mobility group box family member 3 0.0216926
ATXN1 ataxin 1 0.0214971
TNS4 tensin 4 0.0214425
ZSWIM6 zinc finger, SWIM-type containing 6 0.02119
PLSCR2 phospholipid scramblase 2 0.0211893
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0205871
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0205548
ATP11A ATPase, class VI, type 11A 0.0204168
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0201209
SPATA13 spermatogenesis associated 13 0.0200977
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0200575
DSCAM Down syndrome cell adhesion molecule 0.0199806
ZHX2 zinc fingers and homeoboxes 2 0.0199352
MLPH melanophilin 0.0193912
SERINC5 serine incorporator 5 0.0191594
FNIP2 folliculin interacting protein 2 0.0191101
MYO5B myosin VB 0.0188368
PDLIM5 PDZ and LIM domain 5 0.0187053
CEMIP2 cell migration inducing hyaluronidase 2 0.0182735
TPP2 tripeptidyl peptidase II 0.0181316
BAIAP2L1 BAI1-associated protein 2-like 1 0.0177219
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0175817
POF1B premature ovarian failure, 1B 0.0173704
UBAP2 ubiquitin associated protein 2 0.0172447
LARP4B La ribonucleoprotein domain family, member 4B 0.0172234
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0171936
TJP1 tight junction protein 1 0.0171695
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0171078
PADI1 peptidyl arginine deiminase, type I 0.017078
DPP4 dipeptidyl-peptidase 4 0.0170424
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0167489
KYNU kynureninase 0.0166933
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0164876
CTNND1 catenin (cadherin-associated protein), delta 1 0.0158388
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.0157503
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0155049
IGF1R insulin-like growth factor 1 receptor 0.0154708
TMEM65 transmembrane protein 65 0.0154589
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0153316
NCEH1 neutral cholesterol ester hydrolase 1 0.015254
KDM6A lysine (K)-specific demethylase 6A 0.0152474
JAK1 Janus kinase 1 0.0151478
SH3RF1 SH3 domain containing ring finger 1 0.0149552
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0149224

decreased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin -0.210367
TPT1 tumor protein, translationally-controlled 1 -0.144503
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.127455
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.117558
HLA-B major histocompatibility complex, class I, B -0.107916
LCN2 lipocalin 2 -0.084126
PTMA prothymosin, alpha -0.0822386
IFI6 interferon, alpha-inducible protein 6 -0.0768134
ZMYND8 zinc finger, MYND-type containing 8 -0.0766839
RPS6 ribosomal protein S6 -0.0614354
RPL35A ribosomal protein L35a -0.0543757
NDRG1 N-myc downstream regulated 1 -0.0540783
FTL ferritin, light polypeptide -0.0529313
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0512549
EIF1 eukaryotic translation initiation factor 1 -0.0505503
IFI27 interferon, alpha-inducible protein 27 -0.0470747
TMSB10 thymosin beta 10 -0.0456288
PERP PERP, TP53 apoptosis effector -0.0455067
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0450709
TXNIP thioredoxin interacting protein -0.0444026
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0441474
LOC102724023 ES1 protein homolog, mitochondrial -0.0440485
RPLP1 ribosomal protein, large, P1 -0.0436608
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0427399
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0424986
MT2A metallothionein 2A -0.0421155
HLA-A major histocompatibility complex, class I, A -0.0416998
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0412242
EGR1 early growth response 1 -0.0410912
HLA-C major histocompatibility complex, class I, C -0.0404379
RPL23 ribosomal protein L23 -0.0393461
PKM pyruvate kinase, muscle -0.0372809
HLA-E major histocompatibility complex, class I, E -0.0370095
RPL34 ribosomal protein L34 -0.0368206
RPS19 ribosomal protein S19 -0.036424
RPS8 ribosomal protein S8 -0.036304
EPCAM epithelial cell adhesion molecule -0.0350368
CALR calreticulin -0.0345482
RPL19 ribosomal protein L19 -0.034505
ENO1 enolase 1, (alpha) -0.0340366
RPL11 ribosomal protein L11 -0.0339555
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0330518
LYZ lysozyme -0.0330495
UBC ubiquitin C -0.0329467
RPL12 ribosomal protein L12 -0.0328529
FOS FBJ murine osteosarcoma viral oncogene homolog -0.031901
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0318745
PDIA3 protein disulfide isomerase family A, member 3 -0.0314542
S100A10 S100 calcium binding protein A10 -0.0309019
RPL26 ribosomal protein L26 -0.0304346
PGK1 phosphoglycerate kinase 1 -0.0303399
SLC38A1 solute carrier family 38, member 1 -0.0301938
RPS27 ribosomal protein S27 -0.0294556
RHOBTB3 Rho-related BTB domain containing 3 -0.0290239
LOC112694756 uncharaterized LOC112694756 -0.0287662
S100A6 S100 calcium binding protein A6 -0.0285291
RRBP1 ribosome binding protein 1 -0.0283359
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0283327
IRF1 interferon regulatory factor 1 -0.0278873
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0277392
DSTN destrin (actin depolymerizing factor) -0.0276936
H3-3B H3.3 histone B -0.027333
VDAC1 voltage-dependent anion channel 1 -0.0271712
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0270662
RPS24 ribosomal protein S24 -0.0269721
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0267828
RPLP2 ribosomal protein, large, P2 -0.0263119
RPS3 ribosomal protein S3 -0.0262964
TPI1 triosephosphate isomerase 1 -0.0261957
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0259026
WSB1 WD repeat and SOCS box containing 1 -0.0257354
RPL31 ribosomal protein L31 -0.0257325
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0254613
RPS29 ribosomal protein S29 -0.0253474
ACTG1 actin gamma 1 -0.0250556
RNF149 ring finger protein 149 -0.0249478
S100A9 S100 calcium binding protein A9 -0.0249299
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0248524
RPL37 ribosomal protein L37 -0.0246928
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0245584
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0245326
RPL37A ribosomal protein L37a -0.0244223
IFITM3 interferon induced transmembrane protein 3 -0.0242628
EZR ezrin -0.0242034
GCC2 GRIP and coiled-coil domain containing 2 -0.0238952
NAMPT nicotinamide phosphoribosyltransferase -0.0236359
KRT19 keratin 19, type I -0.0234916
RPS13 ribosomal protein S13 -0.0232512
LDHA lactate dehydrogenase A -0.0231186
CSTB cystatin B (stefin B) -0.0231108
RPS23 ribosomal protein S23 -0.0230394
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.022766
MPHOSPH8 M-phase phosphoprotein 8 -0.0225247
RPL18 ribosomal protein L18 -0.0220321
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0219162
CST3 cystatin C -0.0215534
DIAPH3 diaphanous-related formin 3 -0.0213503
SERF2 small EDRK-rich factor 2 -0.0213479
ISG15 ISG15 ubiquitin-like modifier -0.0211992
RPL28 ribosomal protein L28 -0.0211956