| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Capivasertib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.197864 |
| COL6A3 | collagen, type VI, alpha 3 | 0.175956 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.117643 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0933099 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0796265 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0789617 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0751247 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0642614 |
| ATP13A3 | ATPase type 13A3 | 0.058555 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0564168 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0520748 |
| CADM1 | cell adhesion molecule 1 | 0.0470183 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0469837 |
| PTK2 | protein tyrosine kinase 2 | 0.0443469 |
| RASA2 | RAS p21 protein activator 2 | 0.0439879 |
| CD44 | CD44 molecule (Indian blood group) | 0.0409676 |
| MRTFA | myocardin related transcription factor A | 0.0401641 |
| NAV2 | neuron navigator 2 | 0.0395665 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0395178 |
| HMGA2 | high mobility group AT-hook 2 | 0.0385256 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0383416 |
| FMNL2 | formin-like 2 | 0.03659 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0365075 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0362393 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0351893 |
| CDH13 | cadherin 13 | 0.0340076 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0339829 |
| SMAD3 | SMAD family member 3 | 0.0328099 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0324185 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0322139 |
| PDE10A | phosphodiesterase 10A | 0.0316985 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0312368 |
| PLEC | plectin | 0.0302654 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0300963 |
| SPAG9 | sperm associated antigen 9 | 0.0299322 |
| APP | amyloid beta (A4) precursor protein | 0.0281883 |
| CLIC4 | chloride intracellular channel 4 | 0.0281302 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0279625 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0274617 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0270263 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0261802 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0261667 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0260871 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0257391 |
| MSN | moesin | 0.0250428 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0250406 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0246864 |
| AHNAK | AHNAK nucleoprotein | 0.0245465 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0242014 |
| MYO10 | myosin X | 0.0240645 |
| FAT1 | FAT atypical cadherin 1 | 0.0233733 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0231615 |
| FLNA | filamin A, alpha | 0.0231525 |
| MTSS1 | metastasis suppressor 1 | 0.0231349 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0226521 |
| RIGI | RNA sensor RIG-I | 0.0225416 |
| DENND5A | DENN/MADD domain containing 5A | 0.0224605 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0223452 |
| VEGFC | vascular endothelial growth factor C | 0.0220408 |
| VMP1 | vacuole membrane protein 1 | 0.0217705 |
| ZNF292 | zinc finger protein 292 | 0.0212372 |
| KIF1B | kinesin family member 1B | 0.0212311 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0208066 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.020722 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0206084 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.020563 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0204312 |
| TFG | TRK-fused gene | 0.0204203 |
| VCL | vinculin | 0.0203223 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0202373 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0199849 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0198298 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.019627 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0193123 |
| TSC22D2 | TSC22 domain family, member 2 | 0.019205 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0191461 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0189885 |
| COG5 | component of oligomeric golgi complex 5 | 0.0189705 |
| NAV1 | neuron navigator 1 | 0.0188706 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0184394 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0183913 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0183854 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0183708 |
| NOTCH2 | notch 2 | 0.0182915 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.018264 |
| ELOVL5 | ELOVL fatty acid elongase 5 | 0.0182221 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0181068 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0178929 |
| RLF | rearranged L-myc fusion | 0.0178762 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.017733 |
| RUNX1 | runt-related transcription factor 1 | 0.0174784 |
| COPA | coatomer protein complex, subunit alpha | 0.0173769 |
| HIP1 | huntingtin interacting protein 1 | 0.0172153 |
| TRAM2 | translocation associated membrane protein 2 | 0.0171059 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0168274 |
| MED13L | mediator complex subunit 13-like | 0.016729 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0166932 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0166458 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | 0.016604 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0165973 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.422107 |
| VIM | vimentin | -0.222461 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.131268 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.112588 |
| IER3 | immediate early response 3 | -0.0761285 |
| NDRG1 | N-myc downstream regulated 1 | -0.072906 |
| TMSB10 | thymosin beta 10 | -0.0707516 |
| FTL | ferritin, light polypeptide | -0.0669613 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0659511 |
| TPM4 | tropomyosin 4 | -0.0593153 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0554604 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0472275 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.045275 |
| PTMA | prothymosin, alpha | -0.0418069 |
| COL1A2 | collagen, type I, alpha 2 | -0.0416167 |
| RPL35A | ribosomal protein L35a | -0.0414755 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0390357 |
| RPS8 | ribosomal protein S8 | -0.0377298 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0363937 |
| STC1 | stanniocalcin 1 | -0.0348172 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0329631 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0329572 |
| CALR | calreticulin | -0.0327649 |
| RRBP1 | ribosome binding protein 1 | -0.0327451 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0316619 |
| MTDH | metadherin | -0.0304547 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0298019 |
| COL1A1 | collagen, type I, alpha 1 | -0.0297644 |
| S100A9 | S100 calcium binding protein A9 | -0.0266403 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0264544 |
| S100A6 | S100 calcium binding protein A6 | -0.0253121 |
| CAVIN1 | caveolae associated protein 1 | -0.0242659 |
| RPS6 | ribosomal protein S6 | -0.0235415 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0234087 |
| UBC | ubiquitin C | -0.0231492 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0228522 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0228497 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0226289 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0225495 |
| GNAS | GNAS complex locus | -0.0222671 |
| RPLP1 | ribosomal protein, large, P1 | -0.022071 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0216114 |
| VCAN | versican | -0.0204863 |
| LOX | lysyl oxidase | -0.0203334 |
| B2M | beta-2-microglobulin | -0.0197886 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.019787 |
| HLA-B | major histocompatibility complex, class I, B | -0.0195181 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0191157 |
| RACK1 | receptor for activated C kinase 1 | -0.0189096 |
| S100A10 | S100 calcium binding protein A10 | -0.0188597 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0181315 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0175773 |
| GOLGB1 | golgin B1 | -0.0175375 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0173342 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0171874 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0168792 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0167258 |
| TMSB4X | thymosin beta 4, X-linked | -0.0166697 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0163936 |
| IL6 | interleukin 6 | -0.0162743 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0162495 |
| SELENOK | selenoprotein K | -0.0160849 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0156801 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0155675 |
| RPL8 | ribosomal protein L8 | -0.0154322 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0151387 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0149552 |
| RPS24 | ribosomal protein S24 | -0.0147142 |
| RPS27A | ribosomal protein S27a | -0.0144429 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0143011 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0142679 |
| CANX | calnexin | -0.0141737 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0141078 |
| SEC61G | Sec61 gamma subunit | -0.014045 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0140395 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0139671 |
| MORF4L2 | mortality factor 4 like 2 | -0.013922 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.0138834 |
| RPL23 | ribosomal protein L23 | -0.0137907 |
| LOXL2 | lysyl oxidase-like 2 | -0.0136738 |
| NUCB2 | nucleobindin 2 | -0.0136126 |
| LMNA | lamin A/C | -0.0135163 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0134284 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0133386 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0133214 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0132988 |
| RPS19 | ribosomal protein S19 | -0.0130756 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0130383 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0129915 |
| GOLGA4 | golgin A4 | -0.0129683 |
| ATF4 | activating transcription factor 4 | -0.0127663 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0127316 |
| ADM | adrenomedullin | -0.0127252 |
| MYADM | myeloid-associated differentiation marker | -0.012523 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0124924 |
| CCDC91 | coiled-coil domain containing 91 | -0.0124748 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0124114 |
| CD63 | CD63 molecule | -0.0123244 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0122646 |
| RPL31 | ribosomal protein L31 | -0.0122645 |
