Capivasertib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capivasertib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Capivasertib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.342921
C3 complement component 3 0.139151
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.126534
SDC4 syndecan 4 0.103367
SVIL supervillin 0.0993972
FNDC3B fibronectin type III domain containing 3B 0.07943
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0760615
FN1 fibronectin 1 0.0692558
TF transferrin 0.0674999
AFDN afadin, adherens junction formation factor 0.0629356
ZFAND3 zinc finger, AN1-type domain 3 0.0607869
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0591761
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0558115
GRB10 growth factor receptor-bound protein 10 0.0551407
DTNA dystrobrevin, alpha 0.0550977
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0536937
MACF1 microtubule-actin crosslinking factor 1 0.0515002
SMAD3 SMAD family member 3 0.0512403
NRIP1 nuclear receptor interacting protein 1 0.0504618
TOP1 topoisomerase (DNA) I 0.0500199
TNS1 tensin 1 0.0490314
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0485739
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0478288
JAK1 Janus kinase 1 0.047705
EEF2 eukaryotic translation elongation factor 2 0.0472145
DSCAM Down syndrome cell adhesion molecule 0.0466077
ANKRD10 ankyrin repeat domain 10 0.0458844
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0447637
CAMTA1 calmodulin binding transcription activator 1 0.0438106
ZEB1 zinc finger E-box binding homeobox 1 0.0433956
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0418455
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0417135
CCNY cyclin Y 0.041648
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0410257
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0406577
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0400341
STRN3 striatin, calmodulin binding protein 3 0.0391974
KIAA1217 KIAA1217 0.0389394
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.038794
PAWR PRKC, apoptosis, WT1, regulator 0.0387908
EPS8 epidermal growth factor receptor pathway substrate 8 0.0385972
QKI QKI, KH domain containing, RNA binding 0.0383009
ANKRD17 ankyrin repeat domain 17 0.0380695
WAC WW domain containing adaptor with coiled-coil 0.0380087
MRTFA myocardin related transcription factor A 0.0371482
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0371113
BCL2L1 BCL2-like 1 0.0369911
MYO1B myosin IB 0.0367176
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0362345
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0362155
SAMD4A sterile alpha motif domain containing 4A 0.0361975
BHLHE40 basic helix-loop-helix family, member e40 0.0360641
EPAS1 endothelial PAS domain protein 1 0.0351532
SPRED2 sprouty-related, EVH1 domain containing 2 0.0345072
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0333929
DIAPH1 diaphanous-related formin 1 0.0333463
MYH9 myosin, heavy chain 9, non-muscle 0.0330712
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0329769
DENND5A DENN/MADD domain containing 5A 0.0326977
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0326205
ELL2 elongation factor, RNA polymerase II, 2 0.0325832
SHB Src homology 2 domain containing adaptor protein B 0.032485
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0324074
HSPA8 heat shock 70kDa protein 8 0.0322012
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.0321413
EIF4B eukaryotic translation initiation factor 4B 0.0320853
PPARD peroxisome proliferator-activated receptor delta 0.0318891
SOD2 superoxide dismutase 2, mitochondrial 0.0318438
RBM19 RNA binding motif protein 19 0.031548
KIF1B kinesin family member 1B 0.0314108
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0313897
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0312928
HSPH1 heat shock 105kDa/110kDa protein 1 0.030874
JMJD1C jumonji domain containing 1C 0.0306878
SETD5 SET domain containing 5 0.0306671
SNX9 sorting nexin 9 0.0306081
TRIO trio Rho guanine nucleotide exchange factor 0.0303299
ASXL1 additional sex combs like transcriptional regulator 1 0.0302944
NPTN neuroplastin 0.0302587
FBXO42 F-box protein 42 0.03014
SESTD1 SEC14 and spectrin domains 1 0.0301011
MTSS1 metastasis suppressor 1 0.0300455
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.029471
INSIG2 insulin induced gene 2 0.0294677
BCAR3 breast cancer anti-estrogen resistance 3 0.0292384
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0291256
USP47 ubiquitin specific peptidase 47 0.0291128
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0289591
RASA2 RAS p21 protein activator 2 0.0289348
AFF1 AF4/FMR2 family, member 1 0.0288776
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0285656
APLP2 amyloid beta (A4) precursor-like protein 2 0.0285459
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0283697
KMT2C lysine (K)-specific methyltransferase 2C 0.0283278
RANBP9 RAN binding protein 9 0.0280758
MYO5B myosin VB 0.0279216
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0277393
GRK3 G protein-coupled receptor kinase 3 0.0276823
ZNF292 zinc finger protein 292 0.0276529
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0275355

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.137092
EHBP1 EH domain binding protein 1 -0.115599
APOA2 apolipoprotein A-II -0.105397
SLC38A2 solute carrier family 38, member 2 -0.0817893
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0754215
CP ceruloplasmin (ferroxidase) -0.0717414
ZBTB20 zinc finger and BTB domain containing 20 -0.0704455
MT2A metallothionein 2A -0.0679517
MAML2 mastermind-like 2 (Drosophila) -0.0661658
DST dystonin -0.0601741
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0584356
NPAS2 neuronal PAS domain protein 2 -0.0507528
PLIN2 perilipin 2 -0.0502628
APOB apolipoprotein B -0.0497761
ENO1 enolase 1, (alpha) -0.0468122
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0455341
DSPP dentin sialophosphoprotein -0.0450096
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0436243
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.041784
GPC6 glypican 6 -0.0410605
VCL vinculin -0.0405512
FRMD5 FERM domain containing 5 -0.040518
TMSB10 thymosin beta 10 -0.0396619
HMGA1 high mobility group AT-hook 1 -0.0388062
FTL ferritin, light polypeptide -0.0383169
RPLP1 ribosomal protein, large, P1 -0.0378025
IGFBP1 insulin-like growth factor binding protein 1 -0.037362
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0365556
KRT18 keratin 18, type I -0.0360296
TM4SF1 transmembrane 4 L six family member 1 -0.0360147
TMEM123 transmembrane protein 123 -0.0359699
EML4 echinoderm microtubule associated protein like 4 -0.035733
PTCHD4 patched domain containing 4 -0.033831
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0335379
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0323829
IFITM1 interferon induced transmembrane protein 1 -0.0323382
IFI6 interferon, alpha-inducible protein 6 -0.031143
RPS24 ribosomal protein S24 -0.0311324
GMDS GDP-mannose 4,6-dehydratase -0.0310984
SOX5 SRY (sex determining region Y)-box 5 -0.0307204
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0303739
LYZ lysozyme -0.0297326
ITGA1 integrin, alpha 1 -0.0295849
ASPH aspartate beta-hydroxylase -0.029297
LRMDA leucine rich melanocyte differentiation associated -0.0292876
RPS27A ribosomal protein S27a -0.0289783
RNF213 ring finger protein 213 -0.0289684
RIGI RNA sensor RIG-I -0.0287378
GPC3 glypican 3 -0.0285827
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0280151
APOE apolipoprotein E -0.0277946
B2M beta-2-microglobulin -0.027623
STK39 serine threonine kinase 39 -0.0275165
TPM4 tropomyosin 4 -0.0275157
RPS19 ribosomal protein S19 -0.027323
PDE4D phosphodiesterase 4D, cAMP-specific -0.0272107
RPLP2 ribosomal protein, large, P2 -0.0270844
S100A9 S100 calcium binding protein A9 -0.0269555
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0267926
EGR1 early growth response 1 -0.026446
IER3 immediate early response 3 -0.0261616
RPS6 ribosomal protein S6 -0.0260319
RRBP1 ribosome binding protein 1 -0.0255546
HMGA2 high mobility group AT-hook 2 -0.0255444
PEG3 paternally expressed 3 -0.0255404
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0251952
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0249157
MX2 MX dynamin-like GTPase 2 -0.0248561
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0247066
AHNAK AHNAK nucleoprotein -0.0242989
STK17A serine/threonine kinase 17a -0.0238841
CALD1 caldesmon 1 -0.0237686
RPS29 ribosomal protein S29 -0.0234117
ACTG1 actin gamma 1 -0.0228919
APOA1 apolipoprotein A-I -0.0227781
C6ORF62 chromosome 6 open reading frame 62 -0.0225879
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0223475
TRIM26 tripartite motif containing 26 -0.0222269
TPT1 tumor protein, translationally-controlled 1 -0.0217776
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0216057
ARHGAP18 Rho GTPase activating protein 18 -0.0215877
DOCK4 dedicator of cytokinesis 4 -0.0214499
UTRN utrophin -0.0211519
ZMYND8 zinc finger, MYND-type containing 8 -0.0209738
LDHA lactate dehydrogenase A -0.0209658
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0209587
FKTN fukutin -0.0209475
PKM pyruvate kinase, muscle -0.0206801
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0205543
NAP1L1 nucleosome assembly protein 1-like 1 -0.020284
LAMA4 laminin, alpha 4 -0.0201338
RPL23 ribosomal protein L23 -0.0200363
PEG10 paternally expressed 10 -0.0197956
RPS23 ribosomal protein S23 -0.0197642
NPR2 natriuretic peptide receptor 2 -0.0197091
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0196478
FILIP1L filamin A interacting protein 1-like -0.0195561
KRT19 keratin 19, type I -0.0191926
RPL34 ribosomal protein L34 -0.0190957
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0190615