| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Capivasertib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Capivasertib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MEF2A | myocyte enhancer factor 2A | 0.0842167 |
| MTSS1 | metastasis suppressor 1 | 0.0736142 |
| TGM2 | transglutaminase 2 | 0.0557567 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0537978 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0528858 |
| LAMA5 | laminin, alpha 5 | 0.0523933 |
| SMAD3 | SMAD family member 3 | 0.0498937 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0450088 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0413044 |
| H1-0 | H1.0 linker histone | 0.041014 |
| NAV2 | neuron navigator 2 | 0.0407827 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0406691 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0392597 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0374303 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0362574 |
| GOLGA4 | golgin A4 | 0.0356237 |
| FNIP1 | folliculin interacting protein 1 | 0.0343229 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0330295 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0315435 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0313037 |
| SEPTIN9 | septin 9 | 0.030628 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0297257 |
| OGA | O-GlcNAcase | 0.029285 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0292632 |
| EFHD2 | EF-hand domain family, member D2 | 0.0289315 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 0.0287902 |
| KIF16B | kinesin family member 16B | 0.0273195 |
| EPHA2 | EPH receptor A2 | 0.0272877 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0269759 |
| KIAA1217 | KIAA1217 | 0.0266415 |
| SQLE | squalene epoxidase | 0.0265718 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0264704 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0263498 |
| LYST | lysosomal trafficking regulator | 0.0254523 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 0.0253496 |
| ANO6 | anoctamin 6 | 0.0247219 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0244863 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0242411 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.024153 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0241308 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0240345 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0239688 |
| PLEC | plectin | 0.0239555 |
| ARRDC3 | arrestin domain containing 3 | 0.0238531 |
| CALU | calumenin | 0.0234301 |
| RNF145 | ring finger protein 145 | 0.0232911 |
| BARX2 | BARX homeobox 2 | 0.0230996 |
| NDRG1 | N-myc downstream regulated 1 | 0.0228787 |
| MYOF | myoferlin | 0.0227158 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0224955 |
| SLK | STE20-like kinase | 0.0224684 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0223017 |
| SRP54 | signal recognition particle 54kDa | 0.0221559 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0220804 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0219069 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0218164 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0217805 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0217481 |
| ANGPTL4 | angiopoietin-like 4 | 0.0217133 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0217068 |
| FOXO3 | forkhead box O3 | 0.0213533 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.02131 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0211735 |
| ADM | adrenomedullin | 0.0209774 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0208649 |
| MEGF6 | multiple EGF-like-domains 6 | 0.020704 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0206411 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0205564 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | 0.0205531 |
| SUCO | SUN domain containing ossification factor | 0.0204042 |
| LIFR | leukemia inhibitory factor receptor alpha | 0.0203504 |
| SDC4 | syndecan 4 | 0.0203287 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0199413 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0196011 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0194291 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0192714 |
| KIF1B | kinesin family member 1B | 0.0192241 |
| COPA | coatomer protein complex, subunit alpha | 0.0190382 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0189886 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0188236 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0185588 |
| DHX34 | DEAH (Asp-Glu-Ala-His) box polypeptide 34 | 0.0184931 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0184602 |
| PTK2 | protein tyrosine kinase 2 | 0.0182211 |
| DENND4C | DENN/MADD domain containing 4C | 0.0181238 |
| ITGAV | integrin, alpha V | 0.0180505 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0180024 |
| BLCAP | bladder cancer associated protein | 0.0179555 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0178493 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0177974 |
| MT1X | metallothionein 1X | 0.0177835 |
| PLPP1 | phospholipid phosphatase 1 | 0.0175268 |
| ANKH | ANKH inorganic pyrophosphate transport regulator | 0.0174332 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0170832 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.016864 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.016829 |
| OSBPL6 | oxysterol binding protein-like 6 | 0.0167138 |
| TOP1 | topoisomerase (DNA) I | 0.016708 |
| NKTR | natural killer cell triggering receptor | 0.0166728 |
| RPL3 | ribosomal protein L3 | 0.0165518 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.461994 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.198449 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.189299 |
| DPYD | dihydropyrimidine dehydrogenase | -0.178 |
| SULF1 | sulfatase 1 | -0.126666 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0964416 |
| FLNB | filamin B, beta | -0.0932078 |
| LMO7 | LIM domain 7 | -0.0917649 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0771523 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0770289 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0747979 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0737637 |
| RIGI | RNA sensor RIG-I | -0.0698699 |
| MECOM | MDS1 and EVI1 complex locus | -0.0676077 |
| RASAL2 | RAS protein activator like 2 | -0.0669336 |
| AHNAK | AHNAK nucleoprotein | -0.0667726 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0660962 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0654878 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0634403 |
| FN1 | fibronectin 1 | -0.0619081 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0613007 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0604333 |
| POTEF | POTE ankyrin domain family, member F | -0.0600566 |
| CDK6 | cyclin-dependent kinase 6 | -0.0598919 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0578581 |
| HMGA2 | high mobility group AT-hook 2 | -0.0572336 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0545361 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.053472 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.052759 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0496195 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.04901 |
| SMYD3 | SET and MYND domain containing 3 | -0.0484292 |
| PALLD | palladin, cytoskeletal associated protein | -0.0483322 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0465097 |
| MYO10 | myosin X | -0.0462784 |
| ITGA6 | integrin, alpha 6 | -0.0456038 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0443902 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0435397 |
| FOXP1 | forkhead box P1 | -0.0428302 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0415132 |
| RAD51B | RAD51 paralog B | -0.0407374 |
| FRMD4B | FERM domain containing 4B | -0.0404517 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0397867 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0393369 |
| ASPH | aspartate beta-hydroxylase | -0.0391606 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0389096 |
| INTS6 | integrator complex subunit 6 | -0.0387932 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.037952 |
| EFNA5 | ephrin-A5 | -0.0379117 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0378228 |
| DST | dystonin | -0.0375689 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0373084 |
| UTRN | utrophin | -0.0371369 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0361541 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0358578 |
| PRSS23 | protease, serine, 23 | -0.0353941 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0352145 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0351417 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0349974 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0349817 |
| DIAPH3 | diaphanous-related formin 3 | -0.0341454 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0335686 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0331335 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0330826 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0324832 |
| RPS21 | ribosomal protein S21 | -0.0324597 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0320674 |
| DGKH | diacylglycerol kinase, eta | -0.031948 |
| TXNRD1 | thioredoxin reductase 1 | -0.0315485 |
| C4BPB | complement component 4 binding protein, beta | -0.0308237 |
| CRACDL | CRACD like | -0.030523 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0303543 |
| CENPF | centromere protein F, 350/400kDa | -0.0303181 |
| LAMC2 | laminin, gamma 2 | -0.0302017 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0299142 |
| DSG2 | desmoglein 2 | -0.0294619 |
| EXOC4 | exocyst complex component 4 | -0.0293176 |
| NRG1 | neuregulin 1 | -0.029239 |
| CSMD2 | CUB and Sushi multiple domains 2 | -0.0287119 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0281435 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0281288 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0277468 |
| ACTG1 | actin gamma 1 | -0.0277416 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0275432 |
| RPS24 | ribosomal protein S24 | -0.0274959 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.027361 |
| PLS3 | plastin 3 | -0.0271404 |
| ANLN | anillin, actin binding protein | -0.02711 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0270159 |
| MKI67 | marker of proliferation Ki-67 | -0.026839 |
| AFG2A | AFG2 AAA ATPase homolog A | -0.0266539 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0266103 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0265976 |
| ACTN4 | actinin, alpha 4 | -0.0265157 |
| MTAP | methylthioadenosine phosphorylase | -0.0262463 |
| TPX2 | TPX2, microtubule-associated | -0.0259124 |
| HDAC9 | histone deacetylase 9 | -0.0259064 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.025791 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0256184 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0254754 |
