Capivasertib_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Capivasertib perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Capivasertib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.121264
FTH1 ferritin, heavy polypeptide 1 0.0892122
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0886044
TPT1 tumor protein, translationally-controlled 1 0.0858143
MBNL2 muscleblind-like splicing regulator 2 0.0823039
TMC5 transmembrane channel-like 5 0.0818323
RPS6 ribosomal protein S6 0.0790613
AKAP13 A kinase (PRKA) anchor protein 13 0.0693105
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0657517
RAB7A RAB7A, member RAS oncogene family 0.0594471
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.057555
BCL2L1 BCL2-like 1 0.0574837
GOLGA4 golgin A4 0.0549984
SEPTIN9 septin 9 0.0549425
AKAP9 A kinase (PRKA) anchor protein 9 0.0526579
FNDC3B fibronectin type III domain containing 3B 0.0524433
FTL ferritin, light polypeptide 0.0523847
EXT1 exostosin glycosyltransferase 1 0.0523336
SRRM2 serine/arginine repetitive matrix 2 0.0517753
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0516373
EIF1 eukaryotic translation initiation factor 1 0.051052
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.049838
UBE2H ubiquitin-conjugating enzyme E2H 0.0483398
RPS12 ribosomal protein S12 0.0477639
SMAD3 SMAD family member 3 0.0477164
AREG amphiregulin 0.0474111
LMO7 LIM domain 7 0.0471848
RPS25 ribosomal protein S25 0.0471585
LCN2 lipocalin 2 0.0468356
KLHL29 kelch-like family member 29 0.046765
ANXA2 annexin A2 0.0460529
HSPA8 heat shock 70kDa protein 8 0.045948
NUPR1 nuclear protein, transcriptional regulator, 1 0.0458087
RPS3 ribosomal protein S3 0.0448923
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0448674
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.044416
HLA-A major histocompatibility complex, class I, A 0.0438114
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0429774
LOC112694756 uncharaterized LOC112694756 0.0416102
SNX9 sorting nexin 9 0.0411631
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0407889
ZFAND3 zinc finger, AN1-type domain 3 0.0395629
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0393341
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.039251
SEC31A SEC31 homolog A (S. cerevisiae) 0.0391321
HM13 histocompatibility (minor) 13 0.0388535
ARHGAP29 Rho GTPase activating protein 29 0.0372267
MCU mitochondrial calcium uniporter 0.036676
H1-0 H1.0 linker histone 0.0366481
RPL27 ribosomal protein L27 0.0363522
SIK3 SIK family kinase 3 0.0361009
KMT2C lysine (K)-specific methyltransferase 2C 0.0359104
RPS8 ribosomal protein S8 0.0351824
ANXA1 annexin A1 0.0339319
JMJD1C jumonji domain containing 1C 0.0335828
CTNND1 catenin (cadherin-associated protein), delta 1 0.033391
MPRIP myosin phosphatase Rho interacting protein 0.0331572
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.03304
N4BP2L2 NEDD4 binding protein 2-like 2 0.0328357
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0327574
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0324017
RPL26 ribosomal protein L26 0.0323626
PLEC plectin 0.0321192
TM9SF4 transmembrane 9 superfamily protein member 4 0.0319177
DSCAM Down syndrome cell adhesion molecule 0.031879
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0316865
RPL28 ribosomal protein L28 0.0316306
HKDC1 hexokinase domain containing 1 0.0314929
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0312587
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0311699
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0306632
SHB Src homology 2 domain containing adaptor protein B 0.030601
RPL19 ribosomal protein L19 0.0305991
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0303978
FAM135A family with sequence similarity 135, member A 0.0302798
CMIP c-Maf inducing protein 0.0298336
CLDN4 claudin 4 0.0292885
GRB10 growth factor receptor-bound protein 10 0.0292482
RPL35A ribosomal protein L35a 0.029131
SLC38A2 solute carrier family 38, member 2 0.028941
VMP1 vacuole membrane protein 1 0.0288608
RPL23 ribosomal protein L23 0.0283431
MYH9 myosin, heavy chain 9, non-muscle 0.0282989
ANKRD17 ankyrin repeat domain 17 0.0278711
RPS19 ribosomal protein S19 0.0276706
COPA coatomer protein complex, subunit alpha 0.0272034
GARS1 glycyl-tRNA synthetase 1 0.0270839
POTEF POTE ankyrin domain family, member F 0.0269454
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) 0.0267784
ARHGAP42 Rho GTPase activating protein 42 0.0263723
BAIAP2L1 BAI1-associated protein 2-like 1 0.0262887
DSTN destrin (actin depolymerizing factor) 0.0260513
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 0.0257882
S100P S100 calcium binding protein P 0.0252184
RPL37 ribosomal protein L37 0.0251583
IFI27 interferon, alpha-inducible protein 27 0.0251169
HLA-B major histocompatibility complex, class I, B 0.0250909
EIF4B eukaryotic translation initiation factor 4B 0.0249718
CALU calumenin 0.0249374
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0248704

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.287227
GMDS GDP-mannose 4,6-dehydratase -0.188096
CEMIP cell migration inducing protein, hyaluronan binding -0.14983
MAML2 mastermind-like 2 (Drosophila) -0.127669
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0900752
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.076271
AHR aryl hydrocarbon receptor -0.0739072
ANLN anillin, actin binding protein -0.0647556
EHBP1 EH domain binding protein 1 -0.0608155
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0601765
TFRC transferrin receptor -0.0570016
SAMD12 sterile alpha motif domain containing 12 -0.0551318
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0506282
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0503936
ITGA6 integrin, alpha 6 -0.0503808
FGFR2 fibroblast growth factor receptor 2 -0.0485591
TRPS1 trichorhinophalangeal syndrome I -0.0463566
ANO1 anoctamin 1, calcium activated chloride channel -0.0436812
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0426776
POF1B premature ovarian failure, 1B -0.0402423
MECOM MDS1 and EVI1 complex locus -0.0391187
RAD51B RAD51 paralog B -0.0390521
DIAPH3 diaphanous-related formin 3 -0.0381704
DIAPH2 diaphanous-related formin 2 -0.0380992
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0368657
SMC4 structural maintenance of chromosomes 4 -0.0368087
FAT1 FAT atypical cadherin 1 -0.0366459
ACACA acetyl-CoA carboxylase alpha -0.0365515
ECT2 epithelial cell transforming 2 -0.0361214
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0357544
DLG1 discs, large homolog 1 (Drosophila) -0.0349625
CDK6 cyclin-dependent kinase 6 -0.0344045
ASPH aspartate beta-hydroxylase -0.0342032
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0312942
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0303812
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0299761
RRBP1 ribosome binding protein 1 -0.0296986
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -0.0295468
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.029302
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0291945
KRT18 keratin 18, type I -0.0289311
XPO1 exportin 1 -0.0288999
BRCA1 breast cancer 1, early onset -0.0287014
MKI67 marker of proliferation Ki-67 -0.0285357
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0284001
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.028046
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0276508
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0276259
ETV6 ets variant 6 -0.0274797
NFIA nuclear factor I/A -0.0268083
KLF5 Kruppel-like factor 5 (intestinal) -0.0267401
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0267031
TNIK TRAF2 and NCK interacting kinase -0.0264266
SPIDR scaffolding protein involved in DNA repair -0.0263992
ADD3 adducin 3 (gamma) -0.0261664
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0260986
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0258969
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0256186
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0252561
ARHGAP6 Rho GTPase activating protein 6 -0.025099
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0249781
ATAD2 ATPase family, AAA domain containing 2 -0.0246176
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0245172
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0241512
PDE4D phosphodiesterase 4D, cAMP-specific -0.0240393
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0240059
TMEM135 transmembrane protein 135 -0.0234887
CENPP centromere protein P -0.0233533
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0232986
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0228369
SCAPER S-phase cyclin A-associated protein in the ER -0.0226781
CCND1 cyclin D1 -0.0225324
DGKH diacylglycerol kinase, eta -0.022288
MTAP methylthioadenosine phosphorylase -0.0221311
EXOC4 exocyst complex component 4 -0.0218549
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0218145
XYLT1 xylosyltransferase I -0.0217516
FANCI Fanconi anemia, complementation group I -0.021693
PHF14 PHD finger protein 14 -0.0215868
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0215382
PRELID2 PRELI domain containing 2 -0.0215051
RFC3 replication factor C (activator 1) 3, 38kDa -0.0213758
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0213066
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0212703
TPX2 TPX2, microtubule-associated -0.0212275
TBC1D5 TBC1 domain family, member 5 -0.0211179
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0210953
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0209128
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0208577
DEK DEK proto-oncogene -0.0208552
CBX3 chromobox homolog 3 -0.0208538
PRKCA protein kinase C, alpha -0.0206291
PCDH7 protocadherin 7 -0.0205999
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0205816
RRM2 ribonucleotide reductase M2 -0.0205103
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0204049
TMEM123 transmembrane protein 123 -0.0201596
AHNAK AHNAK nucleoprotein -0.0199882
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0197424
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0196193